Selective inhibition of dipeptidyl peptidase 4 by targeting a substrate-specific secondary binding site

Biological Chemistry

Volumn 392, Issue 3, 2011, Pages 223-231

  Kühn Wachea, Kerstin ^a   Bärab, Joachim W ^a   Hoffmann, Torsten ^a   Wolf, Raik ^a   Rahfeld, Jens Ulrich ^a   Demuth, Hans Ulrich ^a  

^a PROBIODRUG AG   (Germany)

Author keywords

Dipeptidyl peptidase 4; Neuropeptide Y; Secondary binding site; Substrate specific inhibition; Substrates

Indexed keywords

ALANINE; AMINO ACID; DIPEPTIDYL PEPTIDASE IV; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLYCINE; NEUROPEPTIDE Y; PROLINE; SERINE; VALINE; DIPEPTIDE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GASTRIC INHIBITORY POLYPEPTIDE (3 42); GASTRIC INHIBITORY POLYPEPTIDE (3-42); OLIGOPEPTIDE; PEPTIDE; PEPTIDE FRAGMENT;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN INTERACTION; SECONDARY BINDING SITE; CHEMISTRY; DRUG EFFECT; ENZYME SPECIFICITY; KINETICS; METABOLISM; MOLECULAR GENETICS; PEPTIDE MAPPING; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; BINDING SITES; DIPEPTIDES; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON-LIKE PEPTIDE 1; KINETICS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; PEPTIDES; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

EID: 79953713734     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2011.028     Document Type: Article

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