1,3-Disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 11, 2007, Pages 2966-2970

  Lübbers, Thomas ^a   Böhringer, Markus ^a   Gobbi, Luca ^a   Hennig, Michael ^a   Hunziker, Daniel ^a   Kuhn, Bernd ^a   Löffler, Bernd ^a   Mattei, Patrizio ^a   Narquizian, Robert ^a   Peters, Jens Uwe ^a   Ruff, Yves ^a   Wessel, Hans Peter ^a   Wyss, Pierre ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

2 Aminobenzo a quinolizine; Dipeptidyl peptidase IV; DPP IV inhibitor

Indexed keywords

2 AMINOBENZO[A]QUINOLIZINE DERIVATIVE; 4 AMINOPIPERIDINE DERIVATIVE; ALOGLIPTIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCAGON LIKE PEPTIDE 1; HEMOGLOBIN A1C; PIPERIDINE DERIVATIVE; QUINOLIZINE DERIVATIVE; SAXAGLIPTIN; SITAGLIPTIN; UNCLASSIFIED DRUG; VILDAGLIPTIN;

ARTICLE; CLINICAL TRIAL; DIABETES MELLITUS; DRUG RESEARCH; DRUG STRUCTURE; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; HIGH THROUGHPUT SCREENING; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; SUBSTITUTION REACTION; SYNTHESIS; UNSPECIFIED SIDE EFFECT;

ADENOSINE DEAMINASE; ANTIGENS, CD26; GLYCOPROTEINS; HUMANS; PIPERIDINES; PROTEASE INHIBITORS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34247869769     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.03.072     Document Type: Article

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