Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 3, 2010, Pages 1106-1108

  Boehringer, Markus ^a   Fischer, Holger ^a   Hennig, Michael ^a   Hunziker, Daniel ^a   Huwyler, Joerg ^a   Kuhn, Bernd ^a   Loeffler, Bernd M ^a   Luebbers, Thomas ^a   Mattei, Patrizio ^a   Narquizian, Robert ^a   Sebokova, Elena ^a   Sprecher, Urs ^a   Wessel, Hans Peter ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

DPP IV inhibitors

Indexed keywords

AMINOBENZO[A]QUINOLIZINE DERIVATIVE; BENZENE DERIVATIVE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCOSE; QUINOLIZINE DERIVATIVE; UNCLASSIFIED DRUG; DIPEPTIDYL PEPTIDASE IV; DPP4 PROTEIN, HUMAN; PROTEINASE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; IN VIVO STUDY; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; HUMAN; METABOLISM; X RAY CRYSTALLOGRAPHY; ZUCKER RAT;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; HUMANS; PROTEASE INHIBITORS; QUINOLIZINES; RATS; RATS, ZUCKER;

EID: 74049094489     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.12.025     Document Type: Article

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