Evolution of granule structure and drug content during fluidized bed granulation by X-ray microtomography and confocal Raman spectroscopy

Journal of Pharmaceutical Sciences

Volumn 100, Issue 12, 2011, Pages 5254-5269

  Poutiainen, Sami ^a   Pajander, Jari ^a   Savolainen, Armi ^a   Ketolainen, Jarkko ^a   Järvinen, Kristiina ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Content uniformity; Fluid bed; Granulation; Granule homogeneity; Granule structure; Mixing; Raman spectroscopy; X ray tomography

Indexed keywords

IBUPROFEN;

ARTICLE; CHEMICAL PARAMETERS; CONCENTRATION (PARAMETERS); CONFOCAL RAMAN SPECTROSCOPY; DRUG CONTENT; DRUG GRANULATION; DRUG QUALITY; FLUIDIZED BED; FLUIDIZED BED GRANULATION; GRANULE STRUCTURE; MICRO-COMPUTED TOMOGRAPHY; MOISTURE; PHARMACEUTICAL ENGINEERING; RAMAN SPECTROMETRY; SCANNING ELECTRON MICROSCOPY; STRUCTURE ANALYSIS;

EID: 80054926831     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22719     Document Type: Article

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