Wet granulation in rotary processor and fluid bed: Comparison of granule and tablet properties

AAPS PharmSciTech

Volumn 7, Issue 1, 2006, Pages

  Kristensen, Jakob ^a   Hansen, Vibeke Wallaert ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Fluid bed; Rotary processor; Wet granulation

Indexed keywords

CALCIUM CARBONATE; MICROCRYSTALLINE CELLULOSE; POVIDONE; RIBOFLAVIN;

ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG GRANULATION; FACTORIAL ANALYSIS; FLOW RATE; FLUIDIZED BED; LUBRICATION; PARTICLE SIZE; TABLET DISINTEGRATION TIME; TABLET HARDNESS; TABLET PROPERTY; TORQUE; PHARMACEUTICS; POWDER; TABLET;

PARTICLE SIZE; POWDERS; TABLETS; TECHNOLOGY, PHARMACEUTICAL;

EID: 33645024433     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt070122     Document Type: Article

References (14)

1. Watano S, Sato Y, Miyanami K, Murakami T, Oda N. Scale-up of agitation fluidized bed granulation. Part 1: preliminary experimental approach for optimization of process variables. Chem Pharm Bull (Tokyo). 1995;43:1212-1216.
2. Holm P, Bonde M, Wigmore T. Pelletization by granulation in a roto-processor RP-2. Part 1: effects of process and product variables on granule growth. Pharm Technol Eur. 1996;8:22-36.
3. Turkoglu M, He M, Sakr A. Evaluation of rotary fluidized-bed as a wet granulation equipment. Eur J Pharm Biopharm. 1995;41:388-394.
4. Jäger K-F, Bauer KH. Effects of material motion on agglomeration in the rotary fluidized bed granulator. Drugs Made Ger. 1982;25:61-65.
5. Leuenberger H, Luy B, Struder J. New development in the control of a moist agglomeration and pelletization process. STP Pharma Sci. 1990;6:303-309.
6. Vuppala MK, Parikh DM, Bhagat HR. Application of powder-layering technology and film coating for manufacture of sustained-release pellets using a rotary fluid bed processor. Drug Dev Ind Pharm. 1997;23:687-694.
7. Gu L, Liew CV, Heng PW. Wet spheronization by rotary processing: a multistage single-pot process for producing spheroids. Drug Dev Ind Pharm. 2004;30:111-123.
8. Kristensen J, Schaefer T, Kleinebudde P. Direct pelletization in a rotary processor controlled by torque measurements, I: influence of process variables. Pharm Dev Technol. 2000;5:247-256.
9. Vertommen J, Kinget R. The influence of five selected processing and formulation variables on the particle size, particle size distribution, and friability of pellets produced in a rotary processor. Drug Dev Ind Pharm. 1997;23:39-46.
10. Kristensen J, Schaefer T, Kleinebudde P. Direct pelletization in a rotary processor controlled by torque measurement, II: effect of changes in the content of microcrystalline cellulose. AAPS PharmSci. 2000;2:E24.
11. Kristensen J. Direct pelletization in a rotary processor controlled by torque measurements, III: investigation of microcrystalline cellulose and lactose grade. AAPS PharmSciTech. 2005;6:E495-E503.
12. Robinson RL, Hollenbeck RG. Manufacture of spherical acetaminophen pellets: comparison of rotary processing with multiple-step extrusion and spheronization. Pharm Technol. 1991;15:48-56.
13. Petersen FJ, Wørts O, Schæfer T, Sojka PE. Effervescent atomization of aqueous polymer solutions and dispersions. Pharm Dev Technol. 2001;6:201-210.
14. European Pharmacopeia. Strasbourg, France: Council of Europe; 2002.