The consequences of granulate heterogeneity towards breakage and attrition upon fluid-bed drying

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 70, Issue 1, 2008, Pages 402-408

  Nieuwmeyer, Florentine ^a   van der Voort Maarschalk, Kees ^a,b   Vromans, Herman ^a,c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Breakage; Composition; Fluid bed drying; Granule; Heterogeneity; High shear; Lactose; Water

Indexed keywords

LACTOSE;

ARTICLE; DRUG GRANULATION; DRUG GRANULE; FLUIDIZED BED; PARTICLE SIZE; PROCESS CONTROL; PROCESS MONITORING; PROCESS OPTIMIZATION; SHEAR STRESS; WATER CONTENT;

CHEMISTRY, PHARMACEUTICAL; DESICCATION; EXCIPIENTS; LACTOSE; MODELS, CHEMICAL; PARTICLE SIZE; POWDERS; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS; WATER;

EID: 50149115748     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.03.003     Document Type: Article

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