Structure-activity relationship and enzyme kinetic studies on 4-aryl-1H-1,2,3-triazoles as indoleamine 2,3-dioxygenase (IDO) inhibitors

European Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2011, Pages 5680-5687

  Huang, Qiang ^a   Zheng, Maofa ^a   Yang, Shuangshuang ^a   Kuang, Chunxiang ^b   Yu, Cunjing ^a   Yang, Qing ^a  

^a FUDAN UNIVERSITY   (China)

^b TONGJI UNIVERSITY   (China)

Author keywords

4 Aryl 1H 1,2,3 triazoles; Enzyme kinetics; Indoleamine 2,3 dioxygenase; Structure activity relationship

Indexed keywords

4 ARYL 1H 1,2,3 TRIAZOLE; INDOLEAMINE 2,3 DIOXYGENASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME KINETICS; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; STRUCTURE ACTIVITY RELATION;

CATALYTIC DOMAIN; CELL PROLIFERATION; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; TRIAZOLES;

EID: 80054920221     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.08.044     Document Type: Article

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