Protein-bound kynurenine decreases with the progression of age-related nuclear cataract

Investigative Ophthalmology and Visual Science

Volumn 45, Issue 3, 2004, Pages 879-883

  Vazquez, Santiago ^a   Parker, Nicole R ^a,b   Sheil, Margaret ^a   Truscott, Roger J W ^a,b  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HISTIDINE; HYDROGEN PEROXIDE; KYNURENINE; LYSINE; OXYGEN; PROTEIN BOUND KYNURENINE; UNCLASSIFIED DRUG; CRYSTALLIN;

AGE RELATED NUCLEAR CATARACT; AGED; AGING; ARTICLE; AUTOOXIDATION; CATARACT; CONTROLLED STUDY; FILTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONTENT; PROTEIN PROCESSING; ULTRAVIOLET RADIATION FILTER; DISEASE COURSE; HYDROLYSIS; LENS NUCLEUS; METABOLISM;

AGED; AGED, 80 AND OVER; AGING; CATARACT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLINS; DISEASE PROGRESSION; HUMANS; HYDROLYSIS; KYNURENINE; LENS NUCLEUS, CRYSTALLINE; PROTEIN BINDING;

EID: 1542637050     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.03-0558     Document Type: Article

References (34)

1. Truscott RJ. Age-related nuclear cataract: a lens transport problem. Ophthalmic Res. 2000;32:185-194.
2. Taylor LM, Aquilina JA, Jamie JF, Truscott RJW. UV filter instability: consequences for the human lens. Exp Eye Res. 2002;75:165-175.
3. Hood BD, Garner B, Truscott RJ. Human lens coloration and aging. J Biol Chem. 1999;274:32547-32550.
4. Vazquez S, Aquilina JA, Jamie JF, Sheil MM, Truscott RJ. Novel protein modification by kynurenine in human lenses. J Biol Chem. 2002;277:4867-4873.
5. Aquilina JA, Truscott RJW. Cysteine is the initial site of modification of α-crystallin by kynurenine. Biochem Biophys Res Commun. 2000;276:216-223.
6. Chen YC, Reid GE, Simpson RJ, Truscott RJW. Molecular evidence for the involvement of alpha crystallin in the colouration/crosslinking of crystallins in age-related nuclear cataract. Exp Eye Res. 1997;65:835-840.
7. Harding J. Cataract: Biochemistry, Epidemiology and Pharmacology. London: Chapman and Hall; 1991:177-181.
8. Lou MF, Huang QL, Zigler JS Jr. Effect of opacification and pigmentation on human lens protein thiol/disulfide and solubility. Curr Eye Res. 1989;8:883-890.
9. Ortwerth BJ, Olesen PR. Studies on the solubilization of the water-insoluble fraction from human lens and cataract. Exp Eye Res. 1992;55:777-783.
10. Spector, A. Oxidative stress-induced cataract: mechanism of action. FASEB J. 1995;9:1173-1182.
11. Vazquez S, Garner B, Sheil MM, Truscott RJW. Characterisation of the major autoxidation products of 3-hydroxykynurenine under physiological conditions. Free Radic Res. 1999;32:11-23.
12. Tomoda A, Yoneyama Y, Yamaguchi T, Shirao E, Kawasaki K. Mechanism of coloration of human lenses induced by near-ultraviolet-photooxidized 3-hydroxykynurenine. Ophthalmic Res. 1990;22:152-159.
13. Butenandt A, Schafer W, Gore TS, eds. Recent Progress in the Chemistry of Natural and Synthetic Colouring Matters and Related Fields. New York: Academic Press; 1962:13-33.
14. Aquilina JA, Carver JA, Truscott RJ. Oxidation products of 3-Hydroxykynurenine bind to lens proteins: relevance for nuclear cataract. Exp Eye Res. 1997;64:727-735.
15. Aquilina JA, Carver JA, Truscott RJ. Elucidation of a novel polypeptide cross-link involving 3-hydroxykynurenine. Biochemistry. 1999;38:11455-11464.
16. Aquilina JA, Carver JA, Truscott RJW. Polypeptide modification and cross-linking by oxidised 3-hydroxykynurenine. Biochemistry. 2000;39:16176-16184.
17. Stutchbury GM, Truscott RJ. The modification of proteins by 3-hydroxykynurenine. Exp Eye Res. 1993;57:149-155.
18. Taylor LM, Aquilina JA, Jamie JF, Truscott RJW. Glutathione and NADH, but not ascorbate, protect lens proteins from modifications by UV filters. Exp Eye Res. 2002;74:503-511.
19. Truscott RJW, Augusteyn RC. The state of sulfhydryl groups in normal and cataractous human lenses. Exp Eye Res. 1977;25:139-148.
20. Pirie A. Color and solubility of the proteins of human cataract. Invest Ophthalmol. 1968;7:634-642.
21. Truscott RJW, Augusteyn RC. Oxidative changes in human lens proteins during senile nuclear cataract formation. Biochim Biophys Acta. 1977;492:43-52.
22. Fu S, Dean R, Southan M, Truscott R. The hydroxyl radical in lens nuclear cataractogenesis. J Biol Chem. 1998;273:28603-28609.
23. Pau H, Graf P, Sies H. Glutathione levels in human lens: regional distribution in different forms of cataract. Exp Eye Res. 1990;50:17-20.
24. Sweeney MH, Truscott RJ. An impediment to glutathione diffusion in older normal human lenses: a possible precondition for nuclear cataract. Exp Eye Res. 1998;67:587-595.
25. Takikawa O, Littlejohn TK, Truscott RJ. Indoleamine 2,3-dioxygenase in the human lens, the first enzyme in the synthesis of UV filters. Exp Eye Res. 2001;72:271-277.
26. Shirao E, Ando K, Inoue A, Shirao Y, Balasubramanian D. Identification of a novel fluorophore, xanthurenic acid 8-O-beta-D-glucoside in human brunescent cataract. Exp Eye Res. 2001;73:421-431.
27. Garner B, Roberg K, Qian M, Eaton JW, Truscott RJW. Distribution of ferritin and redox-active transition metals in normal and cataractous human lenses. Exp Eye Res. 2000;71:599-607.
28. Garland D. Role of site-specific, metal-catalyzed oxidation in lens aging and cataract: a hypothesis. Exp Eye Res. 1990;50:677-682.
29. Garland D, Zigler JS Jr, Kinoshita J. Structural changes in bovine lens crystallins induced by ascorbate, metal, and oxygen. Arch Biochem Biophys. 1986;251:771-776.
30. Zigler JS Jr, Huang GL, Du XY. Oxidative modification of lens crystallins by H2O2 and chelated iron. Free Rad Biol Med. 1989; 7:499-505.
31. Ellozy AR, Wang RH, Dillon J. Model studies on the photochemical production of lenticular fluorophores. Photochem Photobiol. 1994;59:479-484.
32. Dillon J, Skonieczna M, Mandal K, Paik D. The photochemical attachment of the O-glucoside of 3-hydroxykynurenine to alpha-crystallin: a model for lenticular aging. Photochem Photobiol. 1999;69:248-253.
33. Nagaraj RH, Sell DR, Prabhakaram M, Ortwerth BJ, Monnier VM. High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis. Proc Natl Acad Sci USA. 1991;88: 10257-10261.
34. Biemel KM, Friedl DA, Lederer MO. Identification and quantification of major maillard cross-links in human serum albumin and lens protein: evidence for glucosepane as the dominant compound. J Biol Chem. 2002;277:24907-24915.