A convenient method to measure blood-plasma concentration ratio using routine plasma collection in in vivo pharmacokinetic studies

Journal of Pharmaceutical Sciences

Volumn 100, Issue 12, 2011, Pages 5293-5298

  Berezhkovskiy, Leonid M ^a   Zhang, Xiaolin ^a   Cheong, Jonathan ^a  

^a GENENTECH INC   (United States)

Author keywords

Bioanalysis; Blood cell partitioning; Blood plasma ratio; Distribution; Pharmacokinetics; Protein binding; Thermodynamics

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; DRUG BLOOD LEVEL; DRUG PROTEIN BINDING; IN VIVO STUDY; NONHUMAN; PHARMACOKINETICS; PLASMA; RAT;

EID: 80054915733     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22709     Document Type: Article

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