On the possibility of self-induction of drug protein binding

Journal of Pharmaceutical Sciences

Volumn 99, Issue 10, 2010, Pages 4400-4405

  Berezhkovskiy, Leonid M ^a  

^a GENENTECH INC   (United States)

Author keywords

Allosteric activation; Anomalous protein binding; Concentration dependence of the unbound drug fraction; Pharmacokinetics; Self induction; Two step protein binding; Unbound drug fraction

Indexed keywords

ARTICLE; BINDING AFFINITY; DRUG BINDING SITE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; DRUG PROTEIN BINDING; MEASUREMENT;

EID: 77957376236     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22126     Document Type: Article

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