Anomalous relationship between free drug fraction and its total concentration in drug-protein systems. I. Investigation of propofol binding in model HSA solution

European Journal of Pharmaceutical Sciences

Volumn 34, Issue 1, 2008, Pages 30-36

  Dawidowicz, Andrzej L ^a   Kobielski, Mateusz ^a   Pieniadz, Jaroslaw ^a  

^a MARIA CURIE SK ODOWSKA UNIVERSITY   (Poland)

Author keywords

Free drug; HSA; Hydration layer; Hydrophobic interactions; Propofol

Indexed keywords

HUMAN SERUM ALBUMIN; PROPOFOL;

ALBUMIN BLOOD LEVEL; ARTICLE; CHROMATOGRAPHY; DRUG EFFECT; DRUG PROTEIN BINDING; HUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; WATER STRUCTURE;

AMMONIUM SULFATE; HUMANS; PROPOFOL; PROTEIN BINDING; SERUM ALBUMIN; TEMPERATURE;

EID: 42649096605     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2008.02.004     Document Type: Article

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