Flavin adenine dinucleotide content of quinone reductase 2: Analysis and optimization for structure-function studies

Analytical Biochemistry

Volumn 420, Issue 1, 2012, Pages 84-89

  Leung, Kevin Ka Ki ^a   Litchfield, David W ^a   Shilton, Brian H ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Crystallographic analysis; Flavin adenine dinucleotide; Ligand binding; Quinone reductase

Indexed keywords

CARRIER CONCENTRATION; ELECTRON DENSITY MEASUREMENT; ELECTRONS; ENZYMES; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEOTIDES; QUINONE; STRUCTURAL OPTIMIZATION; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHIC ANALYSIS; FLAVIN ADENINE DINUCLEOTIDE; FLAVIN MONO NUCLEOTIDES (FMN); LIGAND BINDING; QUINONE REDUCTASE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC); STRUCTURE-FUNCTION STUDIES; X-RAY CRYSTALLOGRAPHIC ANALYSIS;

CRYSTAL STRUCTURE;

FLAVINE ADENINE NUCLEOTIDE; QUINONE REDUCTASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DENSITY; HUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI;

EID: 80054914118     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2011.09.011     Document Type: Article

References (28)

1. S. Liao, J.T. Dulaney, and H.G. Williams-Ashman Purification and properties of a flavoprotein catalyzing the oxidation of reduced ribosyl nicotinamide J. Biol. Chem. 237 1962 2981 2987
2. A.K. Jaiswal, P. Burnett, M. Adesnik, and O.W. McBride Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family: extensive polymorphism at the NQO2 gene locus on chromosome 6 Biochemistry 29 1990 1899 1906 (Pubitemid 20074738)
3. Q. Zhao, X.L. Yang, W.D. Holtzclaw, and P. Talalay Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase) Proc. Natl. Acad. Sci. U.S.A 94 1997 1669 1674 (Pubitemid 27113893)
4. A.T. Dinkova-Kostova, and P. Talalay NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector Arch. Biochem. Biophys. 501 2010 116 123
5. F. Vella, G. Ferry, P. Delagrange, and J.A. Boutin NRH:quinone reductase 2: an enzyme of surprises and mysteries Biochem. Pharmacol. 71 2005 1 12 (Pubitemid 41715231)
6. J.S. Duncan, L. Gyenis, J. Lenehan, M. Bretner, L.M. Graves, T.A. Haystead, and D.W. Litchfield An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets Mol. Cell. Proteomics 7 2008 1077 1088 (Pubitemid 351943955)
7. 6-tagged TEV protease Methods Mol. Biol. 498 2009 297 307
8. A.G.W. Leslie The integration of macromolecular diffraction data Acta Crystallogr. D 62 2006 48 57
9. P. Evans Scaling and assessment of data quality Acta Crystallogr. D 62 2006 72 82
10. P.D. Adams, P.V. Afonine, G. Bunkoczi, V.B. Chen, I.W. Davis, N. Echols, J.J. Headd, L.W. Hung, G.J. Kapral, R.W. Grosse-Kunstleve, A.J. McCoy, N.W. Moriarty, R. Oeffner, R.J. Read, D.C. Richardson, J.S. Richardson, T.C. Terwilliger, and P.H. Zwart PHENIX: a comprehensive Python-based system for macromolecular structure solution Acta Crystallogr. D 66 2010 213 221
11. C.E. Foster, M.A. Bianchet, P. Talalay, Q. Zhao, and L.M. Amzel Crystal structure of human quinone reductase type 2, a metalloflavoprotein Biochemistry 38 1999 9881 9886
12. A. Aliverti, B. Curti, and M.A. Vanoni Identifying and quantitating FAD and FMN in simple and in iron-sulfur-containing flavoproteins Methods Mol. Biol. 131 1999 9 23
13. R.J. Knox, T.C. Jenkins, S.M. Hobbs, S. Chen, R.G. Melton, and P.J. Burke Bioactivation of 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy Cancer Res. 60 2000 4179 4186 (Pubitemid 30636602)
14. M. Husain, and V. Massey Reversible resolution of flavoproteins into apoproteins and free flavins Methods Enzymol. 53 1978 429 437
15. V. Massey, and G. Palmer On the existence of spectrally distinct classes of flavoprotein semiquinones: a new method for the quantitative production of flavoprotein semiquinones Biochemistry 5 1966 3181 3189
16. S. Parthasarathy, and M.R. Murthy Analysis of temperature factor distribution in high-resolution protein structures Protein Sci. 6 1997 2561 2567 (Pubitemid 28006693)
17. A.C. Wilson, and A.B. Pardee Regulation of flavin synthesis by Escherichia coli J. Gen. Microbiol. 28 1962 283 303
18. C. Vogl, S. Grill, O. Schilling, J. Stülke, M. Mack, and J. Stolz Characterization of riboflavin (vitamin B2) transport proteins from Bacillus subtilis and Corynebacterium glutamicum J. Bacteriol. 189 2007 7367 7375 (Pubitemid 47557352)
19. C.A. Abbas, and A.A. Sibirny Genetic control of biosynthesis and transport of riboflavin and flavin nucleotides and construction of robust biotechnological producers Microbiol. Mol. Biol. Rev. 75 2011 321 360
20. C. Zheng, Z. Zhao, Y. Li, L. Wang, and Z. Su Effect of IPTG amount on apo- and holo- forms of glycerophosphate oxidase expressed in Escherichia coli Protein Expr. Purif. 75 2011 133 137
21. R.A. Laskowski, M. MacArthur, D.S. Moss, and J.M. Thornton PROCHECK: a program to check the stereochemical quality of protein structures J. Appl. Crystallogr. 26 1993 283 291
22. B. Calamini, B.D. Santarsiero, J.A. Boutin, and A.D. Mesecar Kinetic, thermodynamic, and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2 Biochem. J. 413 2008 81 91 (Pubitemid 351946864)
23. Y. Fu, L. Buryanovskyy, and Z. Zhang Crystal structure of quinone reductase 2 in complex with cancer prodrug CB1954 Biochem. Biophys. Res. Commun. 336 2005 332 338 (Pubitemid 41253438)
24. A. Maiti, P.V.N. Reddy, M. Sturdy, L. Marler, S.D. Pegan, A.D. Mesecar, J.M. Pezzuto, and M. Cushman Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities J. Med. Chem. 52 2009 1873 1884
25. M. Abu Khader, J. Heap, C. De Matteis, B. Kellam, S.W. Doughty, N. Minton, and M. Paoli Binding of the anticancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex J. Med. Chem. 48 2005 7714 7719 (Pubitemid 41698811)
26. Y. Fu, L. Buryanovskyy, and Z. Zhang Quinone reductase 2 is a catechol quinone reductase J. Biol. Chem. 283 2008 23829 23835
27. L. Buryanovskyy, Y. Fu, M. Boyd, Y. Ma, T.-C. Hsieh, J.M. Wu, and Z. Zhang Crystal structure of quinone reductase 2 in complex with resveratrol Biochemistry 43 2004 11417 11426 (Pubitemid 39186963)
28. J.A. Winger, O. Hantschel, G. Superti-Furga, and J. Kuriyan The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2) BMC Struct. Biol. 9 2009 7