Small molecule cyclin-dependent kinase inhibitors protect against neuronal cell death in the ischemic-reperfused rat retina

Journal of Ocular Pharmacology and Therapeutics

Volumn 27, Issue 5, 2011, Pages 419-425

  Sakamoto, Kenji ^a   Ohki, Kayo ^a   Saito, Maki ^a   Nakahara, Tsutomu ^a   Ishii, Kunio ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMO 12,13 DIHYDRO 5H INDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 (6H)DIONE; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P16; PROTEIN P27; REGULATOR PROTEIN; ROSCOVITINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CONTROLLED STUDY; EYE EXAMINATION; IMMUNOBLOTTING; MALE; MORPHOMETRICS; NERVE CELL NECROSIS; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; RETINA GANGLION CELL; RETINA ISCHEMIA;

ANIMALS; CARBAZOLES; CELL CYCLE; CELL CYCLE PROTEINS; CELL DEATH; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 5; CYCLIN-DEPENDENT KINASES; MALE; NEURONS; PROTEIN KINASE INHIBITORS; PURINES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RETINA; UP-REGULATION;

EID: 80054871193     PISSN: 10807683     EISSN: 15577732     Source Type: Journal    
DOI: 10.1089/jop.2010.0141     Document Type: Article

References (35)

1. Louzada-Júnior, P., Dias, J.J., Santos, W.F., Lachat, J.J., Bradford, H.F., and Coutinho-Netto, J. Glutamate release in experimental ischaemia of the retina: An approach using microdialysis. J. Neurochem. 59:358-363, 1992.
2. Choi. D.W. Calcium: Still center-stage in hypoxic-ischemic neuronal cell death. Trends Neurosci. 18:58-60, 1995.
3. Dreyer, E.B. A proposed role for excitotoxicity in glaucoma. J. Glaucoma 7:62-67, 1998. (Pubitemid 28069906)
4. Adachi, K., Fujita, Y., Morizane, C., Akaike, A., Ueda, M., Satoh, M., Masai, H., Kashii, S., and Honda, Y. Inhibition of NMDA receptors and nitric oxide synthase reduces ischemic injury of the retina. Eur. J. Pharmacol. 350:53-57, 1998. (Pubitemid 28288308)
5. Copani, A., Uberti, D., Sortino, M.A., Bruno, V., Nicoletti, F., and Memo, M. Activation of cell-cycle-associated proteins in neuronal death: A mandatory or dispensable path? Trends Neurosci. 24:25-31, 2001. (Pubitemid 32332893)
6. Rashidian, J., Iyirhiaro, G.O., and Park, D.S. Cell cycle machinery and stroke. Biochim. Biophys. Acta 1772:484-493, 2007. (Pubitemid 46400387)
7. Timsit, S., and Menn, B. Cerebral ischemia, cell cycle elements and Cdk5. Biotechnol. J. 2:958-966, 2007. (Pubitemid 47377103)
8. Neve, R.L., and McPhie, D.L. The cell cycle as a therapeutic target for Alzheimer's disease. Pharmacol. Ther. 111:99-113, 2006. (Pubitemid 43786202)
9. Park, D.S., Farinelli, S.E., and Greene, L.A. Inhibitors of cyclin- dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons. J. Biol. Chem. 271:8161-8169, 1996. (Pubitemid 26108644)
10. Osuga, H., Osuga, S., Wang, F., Fetni, R., Hogan, M.J., Slack, R.S., Hakim, A.M., Ikeda, J.E., and Park, D.S. Cyclindependent kinases as a therapeutic target for stroke. Proc. Natl. Acad. Sci. USA 97:10254-10259, 2000.
11. Wang, F., Corbett, D., Osuga, H., Osuga, S., Ikeda, J.E., Slack, R.S., Hogan, M.J., Hakim, A.M., and Park, D.S. Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat. J. Cereb. Blood Flow Metab. 22:171-182, 2002. (Pubitemid 34135648)
12. McKinnon, S.J., Lehman, D.M., Kerrigan-Baumrind, L.A., Merges, C.A., Pease, M.E., Kerrigan, D.F., Ransom, N.L., Tahzib, N.G., Reitsamer, H.A., Levkovitch-Verbin, H., Quigley, H.A., and Zack, D.J. Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. Invest. Ophthalmol. Vis. Sci. 43:1077-1087, 2002. (Pubitemid 34258276)
13. Bayer, A.U., Keller, O.N., Ferrari, F., and Maag, K.P. Association of glaucoma with neurodegenerative diseases with apoptotic cell death: Alzheimer's disease and Parkinson's disease. Am. J. Ophthalmol.133:135-137, 2002. (Pubitemid 34076513)
14. Sakamoto, K., Ohki, K., Saito, M., Nakahara, T., and Ishii, K. Histological protection by donepezil against neurodegeneration induced by ischemia-reperfusion in the rat retina. J. Pharmacol. Sci. 112:327-335, 2010.
15. Miki, A., Otori, Y., Morimoto, T., Okada, M., and Tano, Y. Protective effect of donepezil on retinal ganglion cells in vitro and in vivo. Curr. Eye Res. 31:69-77, 2006. (Pubitemid 43155546)
16. Sortino, M.A., Frasca, G., Chisari, M., Platania, P., Chiechio, S., Vancheri, C., Copani, A., and Canonico, P.L. Novel neuronal targets for the acetylcholinesterase inhibitor donepezil. Neuropharmacol. 47:1198-1204, 2004. (Pubitemid 39572711)
17. Dhavan, R., and Tsai, L.H. A decade of CDK5. Nat. Rev. Mol. Cell Biol. 2:749-759, 2001. (Pubitemid 33679837)
18. Lee, M.S., Kwon, Y.T., Mingwei, L., Peng, J., Friedlander, R.M., and Tsai, L.H. Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 405:360-364, 2000. (Pubitemid 30337070)
19. Cheung, Z.H., Fu, A.K., and Ip, N.Y. Synaptic roles of Cdk5: Implications in higher cognitive functions and neurodegenerative diseases. Neuron 50:13-18, 2006.
20. Lefev̀re, K., Clarke, P.G., Danthe, E.E., and Castagnè, V. Involvement of cyclin-dependent kinases in axotomyinduced retinal ganglion cell death. J. ComNeurol. 447:72-81, 2002. (Pubitemid 34298846)
21. Menn, B., Bach, S., Blevins, T.L., Campbell, M., Meijer, L., and Timsit, S. Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models. PLoS One 5:e12117, 2010.
22. + channel. Eur. J. Pharmacol. 418:89-93, 2001. (Pubitemid 32378814)
23. Sakamoto, K., Yonoki, Y., Kuwagata, M., Saito, M., Nakahara, T., and Ishii, K. Histological protection against ischemia- reperfusion injury by early ischemic preconditioning in rat retina. Brain Res. 1015:154-160, 2004. (Pubitemid 38829749)
24. Sakamoto, K., Yonoki, Y., Kubota, Y., Kuwagata, M., Saito, M., Nakahara, T., and Ishii, K. Inducible nitric oxide synthase inhibitors abolished histological protection by late ischemic preconditioning in rat retina. ExEye Res. 82:512-518, 2006. (Pubitemid 43140720)
25. Sakamoto, K., Kawakami, T., Shimada, M., Yamaguchi, A., Kuwagata, M., Saito, M., Nakahara, T., and Ishii, K. Histological protection by cilnidipine, a dual L/N-type Ca2 + channel blocker, against neurotoxicity induced by ischemiareperfusion in rat retina. ExEye Res. 88:974-982, 2009.
26. Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275, 1951.
27. Sakamoto, K., Hiraiwa, M., Saito, M., Nakahara, T., Sato, Y., Nagao, T., and Ishii, K. Protective effect of all-trans retinoic acid on NMDA-induced neuronal cell death in rat retina. Eur. J. Pharmacol. 635:56-61, 2010.
28. Smith, R.A., Walker, T., Xie, X., and Hou, S.T. Involvement of the transcription factor E2F1/Rb in kainic acid-induced death of murine cerebellar granule cells. Brain Res. Mol. Brain Res. 116:70-79, 2003. (Pubitemid 36993698)
29. Kuroiwa, S., Katai, N., Shibuki, H., Kurokawa, T., Umihira, J., Nikaido, T., Kametani, K., and Yoshimura, N. Expression of cell cycle-related genes in dying cells in retinal ischemic injury. Invest. Ophthalmol. Vis. Sci. 39:610-617, 1998. (Pubitemid 28110695)
30. Kuroiwa, S., Katai, N., and Yoshimura, N. A possible role for p16INK4 in neuronal cell death after retinal ischemiareperfusion injury. Invest. Ophthalmol. Vis. Sci. 40:528-533, 1999. (Pubitemid 29063853)
31. Kato, H., Takahashi, A., and Itoyama, Y. Cell cycle protein expression in proliferating microglia and astrocytes following transient global cerebral ischemia in the rat. Brain Res. Bull. 60:215-221, 2003. (Pubitemid 36561542)
32. Meijer, L., Borgne, A., Mulner, O., Chong, J.P., Blow, J.J., Inagaki, N., Inagaki, M., Delcros, J.G., and Moulinoux, J.P. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur. J. Biochem. 243:527-536, 1997. (Pubitemid 27060443)
33. Adachi, K., Fujita, Y., Morizane, C., Akaike, A., Ueda, M., Satoh, M., Masai, H, Kashii, S., and Honda, Y. Inhibition of NMDA receptors and nitric oxide synthase reduces ischemic injury of the retina. Eur. J. Pharmacol. 350:53-57, 1998. (Pubitemid 28288308)
34. Uemura, A., and Mizota, A. Retinal concentration and protective effect against retinal ischemia of nilvadipine in rats. Eur. J. Ophthalmol.18:87-93, 2008. (Pubitemid 351428555)
35. 2+ channel blocker, reduces glutamate-induced neurotoxicity and ischemia/reperfusion damage in rat retina. ExEye Res. 70:475-484, 2000. (Pubitemid 30658889)