Application of automated dried blood spot sampling and LC-MS/MS for pharmacokinetic studies of AMG 517 in rats

Bioanalysis

Volumn 3, Issue 20, 2011, Pages 2349-2356

  Uyeda, Craig ^a   Pham, Roger ^a   Fide, Stacy ^a   Henne, Kirk ^a   Xu, Guifen ^a   Soto, Marcus ^a   James, Christopher ^a   Wong, Philip ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMG 831664; N [4 [6 [4 (TRIFLUOROMETHYL)PHENYL] 4 PYRIMIDINYLOXY]BENZOTHIAZOL 2 YL]ACETAMIDE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; AUTOMATION; BLOOD SAMPLING; CONTROLLED STUDY; DRIED BLOOD SPOT; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG POTENCY; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; IN VIVO STUDY; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RAT; SIGNAL NOISE RATIO; TANDEM MASS SPECTROMETRY;

ANIMALS; AUTOMATION; BENZOTHIAZOLES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRIED BLOOD SPOT TESTING; MALE; PHARMACOKINETICS; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY; TRPV CATION CHANNELS;

EID: 80054868635     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.11.227     Document Type: Article

References (28)

1. Li W, Tse FLS. Dried blood spot sampling in combination with LC-MS/MS for quantitative analysis of small molecules. Biomed. Chromatogr. 24(1), 49-65 (2010).
2. Patel P, Mulla H, Tanna S et al. Facilitating pharmacokinetic studies in children: a new use of dried blood spots. Arch. Dis. Child. 95(6), 484-487 (2010).
3. Pandya HC, Spooner N, Mulla H. Dried blood spots, pharmacokinetic studies and better medicines for children. Bioanalysis 3(7), 779-786 (2011).
4. Guthrie R, Susi A. A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants. Pediatrics 32(3), 338-343 (1963).
5. Barfield M, Spooner N, Lad R et al. Application of dried blood spots combined with LC-MS/MS for the quantification of acetaminophen in toxicokinetic studies. J. Chromatogr. B 870(1), 32-37 (2008).
6. Clark GT, Haynes JJ, Bayliss MAJ et al. Utilization of DBS within drug discovery: development of a serial microsampling pharmacokinetic study in mice. Bioanalysis 2(8), 1477-1488 (2010).
7. Youhnovski N, Michon J, Latour S. et al. Determination of naproxen using DBS: evaluation & pharmacokinetic comparison of human plasma versus human blood DBS. Bioanalysis 2(8), 1501-1513 (2010).
8. Denniff P, Spooner N. The effect of hematocrit on assay bias when using DBS samples for the quantitative bioanalysis of drugs. Bioanalysis 2(8), 1385-1395 (2010).
9. Rowland M, Emmons GT. Use of dried blood spots in drug development: pharmacokinetic considerations. AAPS J. 12(3), 290-293 (2010).
10. Emmons G, Rowland M. Pharmacokinetic considerations as to when to use dried blood spot sampling. Bioanalysis 2(11), 1791-1796 (2010).
11. Wong P, Pham R, Bruenner BA et al. Increasing efficiency for dried blood spot analysis: prospects for automation and simplified sample analysis. Bioanalysis 2(11), 1787-1789 (2010).
12. Deglon J, Thomas A, Cataldo A et al. On-line desorption of dried blood spot: a novel approach for the direct LC-MS analysis of μ-whole blood samples. J. Pharm. Biomed. Anal. 49(4), 1034-1039 (2009).
13. Deglon J, Thomas A, Daali Y et al. Automated system for on-line desorption of dried blood spots applied to LC-MS/MS pharmacokinetic study of flurbiprofen and its metabolite. J. Pharm. Biomed. Anal. 54(2), 359-367 (2011).
14. Abu-Rabie P, Spooner N. Direct quantitative bioanalysis of drugs in dried blood spot samples using a thin-layer chromatography-mass spectrometer interface. Anal. Chem. 81(24), 10275-10284 (2009).
15. Wiseman JM, Evans CA, Bowen CL et al. Direct analysis of dried blood spots utilizing desorption electrospray ionization (DESI) mass spectrometry. Analyst 135(4), 720-725 (2010).
16. Gordon J, Crawford E, Wu JT et al. Quantitative analysis of dried blood spots by DART (direct analysis in real time)/MS/MS without sample preparation. Presented at: The 58th ASMS Conference on Mass Spectrometry and Allied Topics. Salt Lake City, UT, USA, 23-27 May 2010.
17. Gordon J, Crawford E, Wu JT et al. Quantitative analysis of dried blood spots by DART (direct analysis in real time)/MS/MS without sample preparation. Presented at: The 58th ASMS Conference on Mass Spectrometry and Allied Topics. Salt Lake City, UT, USA, 23-27 May 2010. 17 Swartz ME. UPLCTM: an introduction and review. J. Liq. Chromatogr. Related Technol. 28(7), 1253-1263 (2005).
18. Mather J, Rainville PD, Spooner N et al. Rapid analysis of dried blood spot samples with sub-2- μm LC-MS/MS. Bioanalysis 3(4), 411-420 (2011).
19. Jamali F, Kunz-Dober CM. Pain-mediated altered absorption and metabolism of ibuprofen: an explanation for decreased serum enantiomer concentration after dental surgery. Br. J. Clin. Pharmacol. 47(4), 391-396 (1999). (Pubitemid 29161271)
20. Altholtz LY, Fowler KA, Badura LI et al. Comparison of the stress response in rats to repeated isoflurane or CO2:O2 anesthesia used for restraint during serial blood collection via the jugular vein. J. Am. Assoc. Lab. Anim. Sci. 45(3), 17-22 (2006). (Pubitemid 43828864)
21. Vachon P, Moreau JP. Serum corticosterone and blood glucose in rats after two jugular vein blood sampling methods: comparison of the stress response. Contemp. Top. Lab. Anim. Sci. 40(5), 22-24 (2001). (Pubitemid 33674824)
22. Wong P, Pham R, Whitely C et al. Application of automated serial blood sampling and dried blood spot technique with liquid chromatography-tandem mass spectrometry for pharmacokinetic studies in mice. J. Pharma. Biomed. Anal. 56(3), 604-608 (2011).
23. Clark GT, Giddens G, Burrows L et al. Utilization of dried blood spots within drug discovery: modification of a standard DiLab® AccuSampler® to facilitate automatic dried blood spot sampling. Lab. Anim. 45(2), 124-126 (2011).
24. D'Arienzo CJ, Ji QC, Discenza I et al. DBS sampling can be used to stabilize prodrugs in drug discovery rodent studies without the addition of esterase inhibitors. Bioanalysis 2(8), 1415-1422 (2010).
25. Bak A, Gore A, Yanez E et al. The co-crystal approach to improve the exposure of a water-insoluble compound: AMG 517 sorbic acid co-crystal characterization and pharmacokinetics. J. Pharma. Sci. 97(9), 3942-3956 (2008).
26. Kehler JR, Bowen CL, Boram S et al. Application of DBS for quantitative assessment of the peptide Exendin-4; comparison of plasma and DBS method by UHPLC-MS/MS. Bioanalysis 2(8), 1461-1468 (2010).
27. Gritti F, Sanchez CA, Farkas T et al. Achieving the full performance of highly efficient columns by optimizing conventional benchmark high-performance liquid chromatography instruments. J. Chromatogr. A 1217(18), 3000-3012 (2010).
28. Phadnis R, Moore E, Pham R et al. Application of DBS to the pharmacokinetic evaluation of compounds with various blood-to-plasma ratios using LC-MS/MS. Presented at: The 59th ASMS Conference on Mass Spectrometry and Allied Topics. Denver, CO, USA, 5-9 June 2011.