Dried blood spot punches for confirmation of suspected γ- hydroxybutyric acid intoxications: Validation of an optimized GC-MS procedure

Bioanalysis

Volumn 3, Issue 20, 2011, Pages 2271-2281

  Ingels, Ann Sofie ^a   De Paepe, Peter ^b   Anseeuw, Kurt ^c   Van Sassenbroeck, Diederik ^d   Neels, Hugo ^c,e   Lambert, Willy ^a   Stove, Christophe ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c Stuivenberg General Hospital   (Belgium)

^d Emergency Care Department   (Belgium)

^e UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYBUTYRIC ACID; COCAINE; METHAMPHETAMINE; MORPHINE; MORPHINE 6 ACETATE;

4 HYDROXYBUTYRIC ACID INTOXICATION; ACCURACY; ARTICLE; ASSAY; BLOOD SAMPLING; BLOOD STORAGE; CALIBRATION; CONTROLLED STUDY; DERIVATIZATION; DRIED BLOOD SPOT; FOOD AND DRUG ADMINISTRATION; GAS CHROMATOGRAPHY; HEMATOCRIT; HUMAN; INTOXICATION; MASS SPECTROMETRY; SCREENING TEST; SENSITIVITY ANALYSIS; TRAFFIC AND TRANSPORT; UNITED STATES; VALIDATION PROCESS;

DRIED BLOOD SPOT TESTING; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEMATOCRIT; HUMANS; HYDROXYBUTYRATES;

EID: 80054866763     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.11.204     Document Type: Article

References (30)

1. Andresen H, Stimpfl T, Sprys N et al. Liquid ecstasy - a significant drug problem. Dtsch. Arztebl. Int. 105(36), 599-603 (2008).
2. Andresen H, Sprys N, Schmoldt A et al. γ-Hydroxybutyrate in urine and serum: additional data supporting current cut-off recommendations. Forensic Sci. Int. 200(1-3), 93-99 (2010).
3. Carter LP, Pardi D, Gorsline J et al. Illicit gamma-hydroxybutyrate (GHB) and pharmaceutical sodium oxybate (xyrem): differences in characteristics and misuse. Drug Alcohol Depend. 104(1-2), 1-10 (2009).
4. Shima N, Miki A, Kamata T et al. Endogenous level and in vitro production of GHB in blood from healthy humans, and the interpretation of GHB levels detected in antemortem blood samples. J. Health Sci. 51(2), 147-154 (2005). (Pubitemid 40628459)
5. Berankova K, Mutnanska K, Balikova M. Gamma-hydroxybutyric acid stability and formation in blood and urine. Forensic Sci. Int. 161(2-3), 158-162 (2006). (Pubitemid 44142906)
6. Abanades S, Farre M, Segura M et al. γ-hydroxybutyrate (GHB) in humans: pharmacodynamics and pharmacokinetics. Ann. NY Acad. Sci. 1074, 559-576 (2006). (Pubitemid 44532860)
7. Jones AW, Holmgren A, Kugelberg FC. Driving under the influence of γ-hydroxybutyrate (GHB). Forensic Sci. Med. Pathol. 4(4), 205-211 (2008).
8. Edelbroek PM, Van Der Heijden J, Stolk LM. Dried blood spot methods in therapeutic drug monitoring: methods, assays, and pitfalls. Ther. Drug Monit. 31(3), 327-336 (2009).
9. De Boer T, Wieling J, Meulman E et al. Application of dried blood spot sampling combined with LC-MS/MS for genotyping and phenotyping of CYP450 enzymes in healthy volunteers. Biomed. Chromatogr. 25(10), 112-1123 (2011).
10. Li W, Tse F. Dried blood spot sampling in combination with LC-MS/MS for quantitative analysis of small molecules. Biomed. Chromatogr. 24(1), 49-65 (2010).
11. Ingels A, Lambert W, Stove C. Determination of gamma-hydroxybutyric acid in dried blood spots using a simple GC-MS method with direct 'on-spot' derivatization. Anal. Bioanal. Chem. 398(5), 2173-2182 (2010).
12. Garcia Boy R, Henseler J, Mattern R et al. Determination of morphine and 6-acetylmorphine in blood with use of dried blood spots. Ther. Drug Monit. 30(6), 733-739 (2008).
13. Mercolini L, Mandrioli R, Gerra G et al. Analysis of cocaine and two metabolites in dried blood spots by liquid chromatography with fluorescence detection a novel test for cocaine and alcohol intake. J. Chromatogr. A 1217(46), 7242-7248 (2010).
14. Jantos R, Veldstra JL, Mattern R et al. Analysis of 3,4- Methylenedioxymetamphetamine: whole blood versus dried blood spots. J. Anal. Tox. 35(5), 269-273 (2011).
15. Spooner N, Lad R, Barfield M. Dried blood spots as a sample collection technique for the determination of pharmacokinetics in clinical studies: considerations for the validation of a quantitative bioanalytical method. Anal. Chem. 81(4), 1557-1563 (2009).
16. Kolocouri F, Dotsikas Y, Loukas YL. Dried plasma spots as an alternative sample collection technique for the quantitative LC-MS/MS determination of gabapentin. Anal. Bioanal. Chem. 398(3), 1339-1347 (2010).
17. Wilhelm AJ, Den Burger JC, Vos RM et al. Analysis of cyclosporin A in dried blood spots using liquid chromatography tandem mass spectrometry. J. Chromatogr. B 877, 1595-1598 (2009).
18. Almeida AM, Castel-Branco MM, Falcao AC. Linear regression for calibration lines revisited: weighting schemes for bioanalytical methods. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 774(2), 215-222 (2002). (Pubitemid 34655493)
19. Wille SM, Peters FT, Di Fazio V et al. Practical aspects concerning validation and quality control for forensic and clinical bioanalytical quantitative methods. Accred. Qual. Assur. 16(6), 279-292 (2011).
20. Van hee P, Neels H, De Doncker M et al. Analysis of gamma-hydroxybutyric acid, dl-lactic acid, glycolic acid, ethylene glycol and other glycols in body fluids by a direct injection gas chromatography-mass spectrometry assay for wide use. Clin. Chem. Lab. Med. 42(11), 1341-1345 (2004). (Pubitemid 39600334)
21. Schutt BS, Weber K, Elmlinger MW et al. Measuring IGF-I, IGFBP-2 and IGFBP-3 from dried blood spots on filter paper is not only practical but also reliable. Growth Horm. IGF Res. 13(2-3), 75-80 (2003). (Pubitemid 36701652)
22. Holub M, Tuschl K, Ratschmann R et al. Influence of hematocrit and localisation of punch in dried blood spots on levels of amino acids and acylcarnitines measured by tandem mass spectrometry. Clin. Chim. Acta 373(1-2), 27-31 (2006). (Pubitemid 44292169)
23. Vu DH, Koster RA, Alffenaar JW et al. Determination of moxifloxacin in dried blood spots using LC-MS/MS and the impact of the hematocrit and blood volume. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 879(15-16), 1063-1070 (2011).
24. Rainey PM. Relation between serum and whole-blood ethanol concentrations. Clin. Chem. 39(11), 2288-2292 (1993). (Pubitemid 23333321)
25. Emmons G, Rowland M. Pharmacokinetic considerations as to when to use dried blood spot sampling. Bioanalysis 2(11), 1791-1796 (2010).
26. Elliott SP. Nonfatal instances of intoxication with gamma-hydroxybutyrate in the United Kingdom. Ther. Drug Monit. 26(4), 432-440 (2004). (Pubitemid 38989663)
27. Wood DM, Nicolaou M, Dargan PI. Epidemiology of recreational drug toxicity in a nightclub environment. Subst. Use Misuse 44(11), 1495-1502 (2009).
28. D'Arienzo CJ, Ji QC, Discenza L et al. DBS sampling can be used to stabilize prodrugs in drug discovery rodent studies without the addition of esterase inhibitors. Bioanalysis 2(8), 1415-1422 (2010).
29. Abu-Rabie P, Spooner N. Direct quantitative bioanalysis of drugs in dried blood spot samples using a thin-layer chromatography mass spectrometer interface. Anal. Chem. 81(24), 10275-10284 (2009).
30. Déglon J, Thomas A, Mangin P et al. Direct analysis of dried blood spots coupled with mass spectrometry: concepts and biomedical applications. Anal. Bioanal. Chem. DOI 10.1007/s00216-011-5161-5166 (2011) (Epub ahead of print).