메뉴 건너뛰기




Volumn 46, Issue 11, 2011, Pages 897-904

Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity

Author keywords

Energy storage; Genetic polymorphisms; Longevity; Thermogenesis; Uncoupling proteins

Indexed keywords

ADULT; AGED; AGING; ARTICLE; CONTROLLED STUDY; ENHANCER REGION; FEMALE; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; ITALY; LONGEVITY; MALE; MIDDLE AGED; PRIORITY JOURNAL; SURVIVAL; UCP1 GENE; VERY ELDERLY;

EID: 80054855464     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2011.07.011     Document Type: Article
Times cited : (26)

References (62)
  • 2
    • 0033785071 scopus 로고    scopus 로고
    • Uncoupling to survive? The role of mitochondrial inefficiency in ageing
    • Brand M.D. Uncoupling to survive? The role of mitochondrial inefficiency in ageing. Exp. Gerontol. 2000, 35:811-820.
    • (2000) Exp. Gerontol. , vol.35 , pp. 811-820
    • Brand, M.D.1
  • 3
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: function and physiological significance
    • Cannon B., Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 2004, 84:277-359.
    • (2004) Physiol. Rev. , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 4
    • 77953809603 scopus 로고    scopus 로고
    • Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans)
    • Cannon B., Nedergaard J. Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans). Int. J. Obes. (Lond) 2010, 34(Suppl. 1):S7-S16.
    • (2010) Int. J. Obes. (Lond) , vol.34 , Issue.SUPPL. 1
    • Cannon, B.1    Nedergaard, J.2
  • 6
    • 79958097486 scopus 로고    scopus 로고
    • A common polymorphism in the UCP3 promoter influences hand grip strength in elderly people
    • Crocco P., Montesanto A., Passarino G., Rose G. A common polymorphism in the UCP3 promoter influences hand grip strength in elderly people. Biogerontology 2011, 12(3):265-271.
    • (2011) Biogerontology , vol.12 , Issue.3 , pp. 265-271
    • Crocco, P.1    Montesanto, A.2    Passarino, G.3    Rose, G.4
  • 9
    • 0034644662 scopus 로고    scopus 로고
    • Transcriptional activation of the human UCP1 gene in a rodent cell line. Synergism of retinoids, isoproterenolo and thiazolidinedione is mediated by a multipartite response element
    • del Mar Gonzales-Barroso M., Pecqueur C., Gelly C., Sanchis D., Alves-Guerra M.C., Bouillaud F., Ricquier D., Cassard-Doulcier A.M. Transcriptional activation of the human UCP1 gene in a rodent cell line. Synergism of retinoids, isoproterenolo and thiazolidinedione is mediated by a multipartite response element. J. Biol. Chem. 2000, 275:31722-31732.
    • (2000) J. Biol. Chem. , vol.275 , pp. 31722-31732
    • del Mar Gonzales-Barroso, M.1    Pecqueur, C.2    Gelly, C.3    Sanchis, D.4    Alves-Guerra, M.C.5    Bouillaud, F.6    Ricquier, D.7    Cassard-Doulcier, A.M.8
  • 10
    • 77953811960 scopus 로고    scopus 로고
    • The role of UCP 1 in production of reactive oxygen species by mitochondria isolated from brown adipose tissue
    • Dlasková A., Clarke K.J., Porter R.K. The role of UCP 1 in production of reactive oxygen species by mitochondria isolated from brown adipose tissue. Biochim. Biophys. Acta 2010, 1797:1470-1476.
    • (2010) Biochim. Biophys. Acta , vol.1797 , pp. 1470-1476
    • Dlasková, A.1    Clarke, K.J.2    Porter, R.K.3
  • 11
    • 85007110786 scopus 로고    scopus 로고
    • Arlequin (version 3.0): an integrated software package for population genetics data analysis
    • Excoffier L., Laval G., Schneider S. Arlequin (version 3.0): an integrated software package for population genetics data analysis. Evol. BioinformOnline 2005, 1:47-50.
    • (2005) Evol. BioinformOnline , vol.1 , pp. 47-50
    • Excoffier, L.1    Laval, G.2    Schneider, S.3
  • 13
    • 33646885699 scopus 로고    scopus 로고
    • Energy metabolism and oxidative stress: impact on the metabolic syndrome and the aging process
    • Frisard M., Ravussin E. Energy metabolism and oxidative stress: impact on the metabolic syndrome and the aging process. Endocrine 2006, 29:27-32.
    • (2006) Endocrine , vol.29 , pp. 27-32
    • Frisard, M.1    Ravussin, E.2
  • 21
    • 20444498707 scopus 로고    scopus 로고
    • The finding of new genetic polymorphism of UCP-1 A-1766G and its effects on body fat accumulation
    • Kim K.S., Cho D., Kim Y.J., Choi S.M., Kim J.Y., Shin S.U., Yoon Y.S. The finding of new genetic polymorphism of UCP-1 A-1766G and its effects on body fat accumulation. Biochim. Biophys. Acta 2005, 1741:149-155.
    • (2005) Biochim. Biophys. Acta , vol.1741 , pp. 149-155
    • Kim, K.S.1    Cho, D.2    Kim, Y.J.3    Choi, S.M.4    Kim, J.Y.5    Shin, S.U.6    Yoon, Y.S.7
  • 22
    • 33745532075 scopus 로고    scopus 로고
    • Prevalence of low HDL cholesterol levels and associated factors among Koreans
    • Kim S.M., Han J.H., Park H.S. Prevalence of low HDL cholesterol levels and associated factors among Koreans. Circ. J. 2006, 70:820-826.
    • (2006) Circ. J. , vol.70 , pp. 820-826
    • Kim, S.M.1    Han, J.H.2    Park, H.S.3
  • 24
    • 78449291034 scopus 로고    scopus 로고
    • Brown fat thermogenesis and body weight regulation in mice: relevance to humans
    • Kozak L.P., Koza R.A., Anunciado-Koza R. Brown fat thermogenesis and body weight regulation in mice: relevance to humans. Int. J. Obes. (Lond) 2010, 34(Suppl. 1):S23-S27.
    • (2010) Int. J. Obes. (Lond) , vol.34 , Issue.SUPPL. 1
    • Kozak, L.P.1    Koza, R.A.2    Anunciado-Koza, R.3
  • 25
  • 26
    • 0024691070 scopus 로고
    • Brown adipose tissue in humans
    • Lean M.E. Brown adipose tissue in humans. Proc. Nutr. Soc. 1989, 48:243-256.
    • (1989) Proc. Nutr. Soc. , vol.48 , pp. 243-256
    • Lean, M.E.1
  • 27
    • 0034611678 scopus 로고    scopus 로고
    • Towards a molecular understanding of adaptive thermogenesis
    • Lowell B.B., Spiegelman B.M. Towards a molecular understanding of adaptive thermogenesis. Nature 2000, 404:652-660.
    • (2000) Nature , vol.404 , pp. 652-660
    • Lowell, B.B.1    Spiegelman, B.M.2
  • 28
    • 77957306517 scopus 로고    scopus 로고
    • Changes in resting metabolic rate in an elderly German population: cross-sectional and longitudinal data
    • Luhrmann P.M., Edelmann-Schafer B., Neuhauser-Berthold M. Changes in resting metabolic rate in an elderly German population: cross-sectional and longitudinal data. J. Nutr. Health Aging 2010, 14:232-236.
    • (2010) J. Nutr. Health Aging , vol.14 , pp. 232-236
    • Luhrmann, P.M.1    Edelmann-Schafer, B.2    Neuhauser-Berthold, M.3
  • 29
    • 72149113036 scopus 로고    scopus 로고
    • Energy expenditure and aging
    • Manini T.M. Energy expenditure and aging. Ageing Res. Rev. 2010, 9:1-11.
    • (2010) Ageing Res. Rev. , vol.9 , pp. 1-11
    • Manini, T.M.1
  • 30
    • 72149118710 scopus 로고    scopus 로고
    • Perspective: does brown fat protect against diseases of aging?
    • Mattson M.P. Perspective: does brown fat protect against diseases of aging?. Aging Res. Rev. 2010, 9:69-76.
    • (2010) Aging Res. Rev. , vol.9 , pp. 69-76
    • Mattson, M.P.1
  • 31
    • 14644390872 scopus 로고    scopus 로고
    • Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems
    • Mattson M.P., Wan R. Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems. J. Nutr. Biochem. 2005, 16:129-137.
    • (2005) J. Nutr. Biochem. , vol.16 , pp. 129-137
    • Mattson, M.P.1    Wan, R.2
  • 32
    • 0033383174 scopus 로고    scopus 로고
    • Brown adipose tissue thermogenesis during aging and senescence
    • McDonald R.B., Horwitz B.A. Brown adipose tissue thermogenesis during aging and senescence. J. Bioenerg. Biomembr. 1999, 31:507-516.
    • (1999) J. Bioenerg. Biomembr. , vol.31 , pp. 507-516
    • McDonald, R.B.1    Horwitz, B.A.2
  • 33
    • 0242721085 scopus 로고    scopus 로고
    • Direct effects of testosterone, 17 betaestradiol, and progesterone on adrenergic regulation in cultured brown adipocytes: potential mechanism for gender-dependent thermogenesis
    • Monjo M., Rodriguez A.M., Palou A., Roca P. Direct effects of testosterone, 17 betaestradiol, and progesterone on adrenergic regulation in cultured brown adipocytes: potential mechanism for gender-dependent thermogenesis. Endocrinology 2003, 144:4923-4930.
    • (2003) Endocrinology , vol.144 , pp. 4923-4930
    • Monjo, M.1    Rodriguez, A.M.2    Palou, A.3    Roca, P.4
  • 35
    • 0034745057 scopus 로고    scopus 로고
    • A polymorphism in the 5' untranslated region and a Met229→Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus
    • Mori H., Okazawa H., Iwamoto K., Maeda E., Hashiramoto M., Kasuga M. A polymorphism in the 5' untranslated region and a Met229→Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus. Diabetologia 2001, 44:373-376.
    • (2001) Diabetologia , vol.44 , pp. 373-376
    • Mori, H.1    Okazawa, H.2    Iwamoto, K.3    Maeda, E.4    Hashiramoto, M.5    Kasuga, M.6
  • 36
    • 79955378915 scopus 로고    scopus 로고
    • Uncoupling protein 1 gene -3826 A/G polymorphism is associated with weight loss on a short-term, controlled-energy diet in young women
    • Nagai N., Sakane N., Kotani K., Hamada T., Tsuzaki K., Moritani T. Uncoupling protein 1 gene -3826 A/G polymorphism is associated with weight loss on a short-term, controlled-energy diet in young women. Nutr. Res. 2011, 31:255-261.
    • (2011) Nutr. Res. , vol.31 , pp. 255-261
    • Nagai, N.1    Sakane, N.2    Kotani, K.3    Hamada, T.4    Tsuzaki, K.5    Moritani, T.6
  • 39
    • 77954606816 scopus 로고    scopus 로고
    • Uncoupling protein 1 decreases superoxide production in brown adipose tissue mitochondria
    • Oelkrug R., Kutschke M., Meyer C.W., Heldmaier G., Jastroch M. Uncoupling protein 1 decreases superoxide production in brown adipose tissue mitochondria. J. Biol. Chem. 2010, 285:21961-21968.
    • (2010) J. Biol. Chem. , vol.285 , pp. 21961-21968
    • Oelkrug, R.1    Kutschke, M.2    Meyer, C.W.3    Heldmaier, G.4    Jastroch, M.5
  • 43
    • 33645888693 scopus 로고    scopus 로고
    • Nutrition and aging: changes in the regulation of energy metabolism with aging
    • Roberts S.B., Rosenberg I. Nutrition and aging: changes in the regulation of energy metabolism with aging. Physiol. Rev. 2006, 86:651-667.
    • (2006) Physiol. Rev. , vol.86 , pp. 651-667
    • Roberts, S.B.1    Rosenberg, I.2
  • 47
    • 34247246709 scopus 로고    scopus 로고
    • The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study
    • Sale M.M., Hsu F.C., Palmer N.D., Gordon C.J., Keene K.L., Borgerink H.M., Sharma A.J., Bergman R.N., Taylor K.D., Saad M.F., Norris J.M. The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study. BMC Endocr. Disord. 2007, 7:1-10.
    • (2007) BMC Endocr. Disord. , vol.7 , pp. 1-10
    • Sale, M.M.1    Hsu, F.C.2    Palmer, N.D.3    Gordon, C.J.4    Keene, K.L.5    Borgerink, H.M.6    Sharma, A.J.7    Bergman, R.N.8    Taylor, K.D.9    Saad, M.F.10    Norris, J.M.11
  • 49
    • 77957370203 scopus 로고    scopus 로고
    • Homeostatic non-shivering thermogenesis in humans facts and hypotheses
    • Son'kin V.D., Kirdin A.A., Andreev R.S., Akimov E.B. Homeostatic non-shivering thermogenesis in humans facts and hypotheses. Hum. Physiol. 2010, 36:599-614.
    • (2010) Hum. Physiol. , vol.36 , pp. 599-614
    • Son'kin, V.D.1    Kirdin, A.A.2    Andreev, R.S.3    Akimov, E.B.4
  • 51
    • 73449125077 scopus 로고    scopus 로고
    • Body composition changes with aging: the cause or the result of alterations in metabolic rate and macronutrient oxidation?
    • St-Onge M.P., Gallagher D. Body composition changes with aging: the cause or the result of alterations in metabolic rate and macronutrient oxidation?. Nutrition 2010, 26:152-155.
    • (2010) Nutrition , vol.26 , pp. 152-155
    • St-Onge, M.P.1    Gallagher, D.2
  • 54
    • 51149091028 scopus 로고    scopus 로고
    • The serum levels of 17β-estradiol, progesterone and triiodothyronine correlate with brown adipose tissue thermogenic parameters during aging
    • Valle A., Santandreu F.M., Garcìa-Palmer F.J., Roca P., Oliver J. The serum levels of 17β-estradiol, progesterone and triiodothyronine correlate with brown adipose tissue thermogenic parameters during aging. Cell. Physiol. Biochem. 2008, 22:337-346.
    • (2008) Cell. Physiol. Biochem. , vol.22 , pp. 337-346
    • Valle, A.1    Santandreu, F.M.2    Garcìa-Palmer, F.J.3    Roca, P.4    Oliver, J.5
  • 58
    • 79958256827 scopus 로고    scopus 로고
    • Is older colder or colder older? The association of age with body temperature in 18,630 individuals
    • Waalen J., Buxbaum J.N. Is older colder or colder older? The association of age with body temperature in 18,630 individuals. J. Gerontol. A Biol. Sci. Med. Sci. 2011, 66(5):487-492.
    • (2011) J. Gerontol. A Biol. Sci. Med. Sci. , vol.66 , Issue.5 , pp. 487-492
    • Waalen, J.1    Buxbaum, J.N.2
  • 60
    • 46349110454 scopus 로고    scopus 로고
    • Human skeletal muscle mitochondrial uncoupling is associated with cold induced adaptive thermogenesis
    • Wijers S.L.J., Schrauwen P., Saris W.H.M., van Marken Lichtenbelt W.D. Human skeletal muscle mitochondrial uncoupling is associated with cold induced adaptive thermogenesis. PLoS ONE 2008, 3:e1777.
    • (2008) PLoS ONE , vol.3
    • Wijers, S.L.J.1    Schrauwen, P.2    Saris, W.H.M.3    van Marken Lichtenbelt, W.D.4
  • 61
    • 78650676545 scopus 로고    scopus 로고
    • Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men
    • Yoneshiro T., Aita S., Matsushita M., Kameya T., Nakada K., Kawai Y., Saito M. Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men. Obesity 2010, 19:13-16.
    • (2010) Obesity , vol.19 , pp. 13-16
    • Yoneshiro, T.1    Aita, S.2    Matsushita, M.3    Kameya, T.4    Nakada, K.5    Kawai, Y.6    Saito, M.7
  • 62
    • 70349334680 scopus 로고    scopus 로고
    • The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
    • Zingaretti M.C., Crosta F., Vitali A., Guerrieri M., Frontini A., Cannon B., Nedergaard J., Cinti S. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J. 2009, 23:3113-3120.
    • (2009) FASEB J. , vol.23 , pp. 3113-3120
    • Zingaretti, M.C.1    Crosta, F.2    Vitali, A.3    Guerrieri, M.4    Frontini, A.5    Cannon, B.6    Nedergaard, J.7    Cinti, S.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.