A new polymorphic site located in the human UCP1 gene controls the in vitro binding of CREB-like factor

International Journal of Obesity

Volumn 26, Issue 5, 2002, Pages 735-738

  Rousset, S ^a   Del Mar Gonzalez Barroso, M ^a   Gelly, C ^a   Pecqueur, C ^a   Bouillaud, F ^a   Ricquier, D ^a   Cassard Doulcier, A M ^a  

^a CNRS   (France)

Author keywords

CREB like site; Isoproterenol; Polymorphism; UCP1 gene

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR; UNCOUPLING PROTEIN 1;

ANIMAL CELL; ARTICLE; BROWN ADIPOSE TISSUE; DNA POLYMORPHISM; ENERGY METABOLISM; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; MOUSE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; OBESITY; POINT MUTATION; PRIORITY JOURNAL; THERMOGENESIS; THERMOREGULATION;

ADIPOSE TISSUE, BROWN; ADRENERGIC BETA-AGONISTS; ANIMALS; BINDING SITES; CARRIER PROTEINS; CELL LINE; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA; GENE EXPRESSION; HUMANS; ION CHANNELS; ISOPROTERENOL; MEMBRANE PROTEINS; MITOCHONDRIAL PROTEINS; MUTAGENESIS; POLYMORPHISM, GENETIC; TRANSFECTION;

ANIMALIA; RODENTIA;

EID: 0036261266     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0801973     Document Type: Article

References (18)

1. Thermogenic mechanisms in brown fat
2. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
3. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
4. Human uncoupling protein gene: Structure, comparison with rat gene, and assignment to the long arm of chromosome 4
5. The Bcl I polymorphism of the human uncoupling protein (ucp) gene is due to a point mutation in the 5′-flanking region
6. DNA polymorphism in the uncoupling protein (UCP) gene and human body fat
7. Additive effect of A→G (- 3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity
8. Polymorphisms of uncoupling protein (UCP) and beta 3 adrenoreceptor genes in obese people submitted to a low calorie diet
9. Uncoupling protein gene: Quantification of expression levels in adipose tissues of obese and non-obese humans
10. Uncoupling protein-1 mRNA expression in obese human subjects: The role of sequence variations at the uncoupling protein-1 gene locus
11. Transcriptional activation of the human ucp1 gene in a rodent cell line. Synergism of retinoids, isoproterenol, and thiazolidinedione is mediated by a multipartiteresponse element
12. The CGTCA sequence motif is essential for biological activity of the vasoactive intestinal peptide gene cAMP-regulated enhancer
13. Cyclic AMP induction of early adenovirus promoters involves sequences required for E1A trans-activation
14. Phosphorylation of CREB affects its binding to high and low affinity sites; implications for cAMP induced gene transcription
15. Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain
16. Structural determinants for transcriptional activation by cAMP-responsive DNA elements
17. Coupling transcription to signal transduction: CREM and cAMP
18. Alpha 1-adrenergic stimulation potentiates the thermogenic action of beta3-adrenoreceptor-generated cAMP in brown fat cells