Acute, subacute and subchronic safety assessment of betalains rich Rivina humilis L. berry juice in rats

Food and Chemical Toxicology

Volumn 49, Issue 12, 2011, Pages 3154-3157

  Khan, Mohammad Imtiyaj ^a   Denny Joseph, K M ^a   Muralidhara, ^a   Ramesh, H P ^a   Giridhar, P ^a   Ravishankar, G A ^a  

^a CENTRAL FOOD TECHNOLOGICAL RESEARCH INSTITUTE   (India)

Author keywords

Acute; Betalains; Rivina humilis L. (Phytolaccaceae); Safety; Subacute; Subchronic

Indexed keywords

BETALAIN;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHEMICAL COMPOSITION; BLOOD ANALYSIS; BODY WEIGHT; CHRONIC TOXICITY; CONTROLLED STUDY; DIET SUPPLEMENTATION; HISTOPATHOLOGY; HOMEOSTASIS; MALE; NONHUMAN; NUTRITIONAL VALUE; ORGAN WEIGHT; PHYTOCHEMISTRY; PHYTOLACCACEAE; RAT; RISK ASSESSMENT; RIVINA HUMILIS; TOXICITY TESTING;

ANIMALS; BETALAINS; BEVERAGES; BODY WEIGHT; FRUIT; MALE; ORGAN SIZE; PHYTOLACCACEAE; PLANT EXTRACTS; RATS; RATS, WISTAR; TOXICITY TESTS;

BETA VULGARIS SUBSP. VULGARIS; CARYOPHYLLALES; PHYTOLACCACEAE; RATTUS; RIVINA HUMILIS;

EID: 80054851711     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.08.022     Document Type: Article

References (18)

1. Clement J.S., Mabry T.J. Pigment evolution in the Caryophyllales: a systematic overview. Bot. Acta 1996, 109:360-367.
2. Gandia-Herrero F., Escribano J., Garcia-Carmona F. The role of phenolic hydroxy groups in the free radical scavenging activity of betalains. J. Nat. Prod. 2009, 72:1142-1146.
3. Kanner J., Harel S., Granit R. Betalains - a new class of dietary antioxidants. J. Agric. Food Chem. 2001, 49:5178-5185.
4. Khan M.I., Sri Harsha P.S.C., Giridhar P., Ravishankar G.A. Pigment identification, antioxidant activity and nutrient composition of Tinospora cordifolia (willd.) Miers ex Hook. f & Thoms berry. Int. J. Food Sci. Nutr. 2011, 62:239-249.
5. Khan M.I., Sri Harsha P.S.C., Giridhar P., Ravishankar G.A. Berberine and lycopene profiling during the ontogeny of Tinospora cordifolia (Willd.) Miers ex Hook. f & Thoms fruit. Curr. Sci. 2011, 100:1225-1231.
6. Lin J.C., Olcott H.S. Ethoxyquin nitroxide. J. Agric. Food Chem. 1975, 23:798-800.
7. Loeb W.F., Quimby F.W. The Clinical Chemistry of Laboratory Animals 1989, Permagon Press, New York, pp. 251-252.
8. Pavlov A., Kovatcheva P., Tuneva D., Ilieva M., Bley T. Radical scavenging activity and stability of betalains from Beta vulgaris hairy root culture in simulated conditions of human gastrointestinal tract. Plant Food Hum. Nutr. 2005, 60:43-47.
9. Reynoso R.C., Giner T.V., de Mejia E.G. Safety of a filtrate of fermented garambullo fruit: biotransformation and toxicity studies. Food Chem. Toxicol. 1999, 37:825-830.
10. Schilter B., Andersson C., Anton R., Constable A., Kleiner J., O'Brien J., Renwick A.G., Korver O., Smit F., Walker R. Guidance for the safety assessment of botanicals and botanical preparations for use in food and food supplements. Food Chem. Toxicol. 2003, 41:1625-1649.
11. Sellers R.S., Morton D., Michael B., Roome N., Johnson J.K., Yano B.L., Perry R., Schafer K. Society of toxicologic pathology position paper: organ weight recommendations for toxicology studies. Toxicol. Pathol. 2007, 35:751-755.
12. Stintzing F.C., Carle R. Betalains - emerging prospects for food scientists. Trends Food Sci. Technol. 2007, 18:514-525.
13. Stintzing F.C., Schieber A., Carle R. Evaluation of colour properties and chemical quality parameters of cactus pear juices. Eur. Food Res. Technol. 2003, 216:303-311.
14. Strack D., Vogt T., Schliemann W. Recent advances in betalain research. Phytochemistry 2003, 62:247-269.
15. Swarbick, J.T., 1997. Environmental weeds and exotic plants on Christmas Island, Indian Ocean. A report to parks Australia, p. 101.
16. Tesoriere L., Allegra M., Butera D., Livrea M.A. Absorption, excretion, and distribution of dietary antioxidant betalains in LDLs: potential health effects of betalains in humans. Am. J. Clin. Nutr. 2004, 80:941-945.
17. Wealth of India, 2008. Raw materials. National Institute of Science Communication and Information Resources (NISCAIR), CSIR, New Delhi, second suppl. series, vol. 3, p. 18.
18. Wooley A. Determination - general and reproductive toxicology. A guide to practical toxicology evaluation, prediction and risk 2003, 80-106. Taylor and Francis, New York.