Medical therapy for premature ejaculation

Therapeutic Advances in Urology

Volumn 3, Issue 5, 2011, Pages 211-222

  Mohee, Amar ^a   Eardley, Ian ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

male sexual dysfunction; medical therapy; medical treatment; premature ejaculation

Indexed keywords

BENZOCAINE; CLOMIPRAMINE; DAPOXETINE; EMLA; ESCITALOPRAM; FLUOXETINE; FLUVOXAMINE; ISOCARBOXAZID; LIDOCAINE; OPIATE DERIVATIVE; PAROXETINE; PHENELZINE; PHENOXYBENZAMINE; PHOSPHODIESTERASE V INHIBITOR; PRILOCAINE; PSD 502; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; SILDENAFIL; TADALAFIL; TERAZOSIN; TRAMADOL; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG; VARDENAFIL;

ABNORMAL VISION; AEROSOL; ANAMNESIS; BEHAVIOR THERAPY; BURNING SENSATION; CONSTIPATION; CREAM; DIAPHORESIS; DIARRHEA; DIZZINESS; DROWSINESS; DYSPEPSIA; ERECTILE DYSFUNCTION; FATIGUE; FLUSHING; HEADACHE; HUMAN; HYPESTHESIA; HYPOTENSION; INSOMNIA; LIBIDO DISORDER; LOOSE FECES; MALE; NAUSEA; PARESTHESIA; PATIENT SATISFACTION; PREMATURE EJACULATION; PRIORITY JOURNAL; PSYCHOTHERAPY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RHINITIS; RHINOPHARYNGITIS; SIDE EFFECT; SKIN IRRITATION; SOMNOLENCE; SWEATING; VOMITING; XEROSTOMIA; YAWNING;

EID: 80054851000     PISSN: 17562872     EISSN: 17562880     Source Type: Journal    
DOI: 10.1177/1756287211424172     Document Type: Review

References (74)

1. Alghobary M.M.D. El-Bayoumy Y.M.D. Mostafa Y.M.D. Mahmoud E.-H.M.M.D. Amr M.M.D. (2010) Evaluation of tramadol on demand vs. daily paroxetine as a long-term treatment of lifelong premature ejaculation. J Sexual Med 7: 2860–2867.
2. Althof S. Levine S. Corty E. Risen C. Stern E. Kurit D. (1995) A double-blind crossover trial of clomipramine for rapid ejaculation in 15 couples. J Clin Psychiatry 56: 402–407.
3. APA. (2000) Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Association.
4. Athanasios Z. Polyanthi P. George K. (2007) The efficacy of duloxetine in the treatment of premature ejaculation. Int Urol Nephrol 39: 115–118.
5. Atikeler M. Gecit I. Senol F. (2002) Optimum usage of prilocaine-lidocaine cream in premature ejaculation. Andologia 34: 356–359.
6. Aversa A. Pili M. Francomano D. Bruzziches R. Spera E. La Pera G. (2009) Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation. Int J Impot Res 21: 221–227.
7. Aycock L. (1949) The medical management of premature ejaculation. J Urol 62: 361–361.
8. Balbay M. Yildiz M. Şalvarci A. Özsan Ö. Özbek E. (1998) Treatment of premature ejaculation with sertralin. Int Urol Nephrol 30: 81–83.
9. Başar M. Yılmaz E. Ferhat M. Başar H. Batislam E. (2005) Terazosin in the treatment of premature ejaculation: a short-term follow-up. Int Urol Nephrol 37: 773–777.
10. Beretta G. Chelo E. Fanciullacci F. Zanollo A. (1986) Effect of an alpha-blocking agent (phenoxybenzamine) in the management of premature ejaculation. Acta Eur Fertil 17: 43–45.
11. Berkovitch M. Keresteci A. Koren G. (1995) Efficacy of prilocaine-lidocaine cream in the treatment of premature ejaculation. J Urol 154: 1360–1361.
12. Biri H. Isen K. Sinik Z. Onaran M. Küpeli B. Bozkirli I. (1998) Sertraline in the treatment of premature ejaculation: A double-blind placebo controlled study. Int Urol Nephrol 30: 611–615.
13. Busato W. Galindo C.C. (2004) Topical anaesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study. BJU Int 93: 1018–1021.
14. Buvat J. Tesfaye F. Rothman M. Rivas D.A. Giuliano F. (2009) Dapoxetine for the treatment of premature ejaculation: results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries. Eur Urol 55: 957–968.
15. Cahangirov A. Cihan A. Murat N. Demir O. Aslan G. Gidener S. (2011) Investigation of the neural target level of hyperthyroidism in premature ejaculation in a rat model of pharmacologically induced ejaculation. J Sexual Med 8: 90–96.
16. Carson C. Wyllie M. (2010) Improved ejaculatory latency, control and sexual satisfaction when PSD502 is applied topically in men with premature ejaculation: results of a phase III, double-blind, placebo-controlled study. J Sex Med 7: 3179–3189.
17. Chan J.S.W. Snoeren E.M.S. Cuppen E. Waldinger M.D. Olivier B. Oosting R.S. (2011) The serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout rats. J Sexual Med 8: 97–108.
18. Chiou W.-F. Wu T.-S. (2011) 9-Hydroxycanthin-6-one induces penile erection and delays ejaculation. J Sexual Med DOI: 10.1111/j.1743-6109.2011.02296.x.
19. Clément P. Pozzato C. Heidbreder C. Alexandre L. Giuliano F. Melotto S. (2009) Delay of Ejaculation Induced by SB-277011, a selective dopamine D3 receptor antagonist, in the rat. J Sexual Med 6: 980–988.
20. Colpi G.M. Fanciullacci F. Beretta G. Negri L. Zanollo A. (1986) Evoked sacral potentials in subjects with true premature ejaculation. Andrologia 18: 583–586.
21. Corona G. Petrone L. Mannucci E. Jannini E.A. Mansani R. Magini A. (2004) Psycho-biological correlates of rapid ejaculation in patients attending an andrologic unit for sexual dysfunctions. Eur Urol 46: 615–622.
22. Damrau F. (1963) Premature ejaculation: Use of ethyl aminobenzoate to prolong coitus. J Urol 89: 936–936.
23. Dinsmore W.W. Hackett G. Goldmeier D. Waldinger M. Dean J. Wright P. (2007) Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation. BJU Int 99: 369–375.
24. Dinsmore W.W. Wyllie M.G. (2009) PSD502 improves ejaculatory latency, control and sexual satisfaction when applied topically 5 min before intercourse in men with premature ejaculation: results of a phase III, multicentre, double-blind, placebo-controlled study. BJU Int 103: 940–949.
25. Feige A.M. Pinsky M.R. Hellstrom W.J. (2011) Dapoxetine for Premature Ejaculation. Clin Pharmacol Therapeut 89: 125–128.
26. Forster P. (1994) Fluoxetine for premature ejaculation. Am J Psychiatry 151: 1523–1523.
27. Giuliano F. Bernabe J. Gengo P. Alexandre L. Clement P. (2007) Effect of acute dapoxetine administration on the pudendal motoneuron reflex in anesthetized rats: comparison with paroxetine. J Urol 177: 386–389.
28. Godpodinoff M. (1989) Premature ejaculation: clinical subgroups and etiology. J Sex Marital Ther 15: 693–705.
29. Grenier G. Byers E. (1995) Rapid ejaculation: A review of conceptual, etiological, and treatment issues. Arch Sex Behav 24: 447–472.
30. Hastings D. (1963) Impotence and Frigidity Boston, MA: Little Brown & Co.
31. Hatzimouratidis K. Amar E. Eardley I. Giuliano F.H.D. Montorsi F. (2010) Guidelines on male sexual dysfunction: Erectile dysfunction and premature ejaculation. Eur Urol in press.
32. Hawton K. Catalan J. Martin P. Fagg J. (1986) Long-term outcome of sex therapy. Behav Res Therapy 24: 665–675.
33. Henry R. Morales A. (2003) Topical lidocaine-prilocaine spray for the treatment of premature ejaculation: a proof of concept study. Int J Impot Res 15: 277–281.
34. Hoy S.M. Scott L.J. (2010) Dapoxetine: in premature ejaculation. Drugs 70: 1433–1443.
35. Jannini E.A. Lombardo F. Lenzi A. (2005) Correlation between ejaculatory and erectile dysfunction. Int J Androl 28: 40–45.
36. Kaufman J.M. Rosen R.C. Mudumbi R.V. Tesfaye F. Hashmonay R. Rivas D. (2009) Treatment benefit of dapoxetine for premature ejaculation: results from a placebo-controlled phase III trial. BJU Int 103: 651–658.
37. Kim S.C. Seo K.K. (1998) Efficacy and safety of fluoxetine, sertraline and clomipramine in patients with premature ejaculation: a double-blind, placebo controlled study. J Urol 159: 425–427.
38. Laumann E. Paik A. Rosen R. (1999) Sexual dysfunction in the United States: Prevalence and predictors. JAMA 281: 537–544.
39. Lue T. Broderick G. Walsh P. Retik A. Vaughan E. Wein A. Kavoussi L. Novick A. (2007) Evaluation and nonsurgical management of erectile dysfunction and premature ejaculation. Campbell-Walsh Urology Vol. 1, Philadelphia, PA: Saunders-Elsevier, 750–787.
40. Marmor J. Sadock B. Kaplan H. Freedman A. (1976) Impotence and ejaculatory disturbances. Sexual Experience Baltimore, MD: The Williams & Wilkins Co, 407–410.
41. Masters W. Johnson V. (1970) Himan Sexual Inadequacy Boston, MA: Little, Brown & Co.
42. McMahon C. Althof S. Kaufman J. Buvat J. Aquilina J. Rivas D. (2009) Efficacy and safety of dapoxetine for premature ejaculation: integrated analysis of 5 phase 3 trials: PD-068. J Sexual Med 6(Suppl. 2): 69–70.
43. McMahon C. Kim S.W. Park N.C. Chang C.-p. Rivas D. Tesfaye F. (2011) Treatment of premature ejaculation in the Asia-Pacific region: results from a phase III double-blind, parallel-group study of dapoxetine. J Sexual Med 7: 256–268.
44. McMahon C.G. Abdo C. Incrocci L. Perelman M. Rowland D. Waldinger M. (2004) Disorders of orgasm and ejaculation in men. J Sexual Med 1: 58–65.
45. McMahon C.G. Stuckey B.G.A. Andersen M. Purvis K. Koppiker N. Haughie S. (2005) Efficacy of sildenafil citrate (Viagra) in men with premature ejaculation. J Sexual Med 2: 368–375.
46. Mendels J. (1995) Sertraline for premature ejaculation. J Clin Psychiatry 56: 591–591.
47. Mohammadreza N. Mehdi A. Mohammad H. (2009) Seminal plasma magnesium and premature ejaculation: a case-control study. Urol J 2: 102–105.
48. Montague D.K. Jarow J. Broderick G.A. Dmochowski R.R. Heaton J.P. Lue T.F. (2004) Premature Ejaculation: Guideline on the pharmacologic management of premature ejaculation. J Urol 172: 290–294.
49. Nathan S. (1986) The epidemiology of the DSM-III psychosexual dysfunctions. J Sex Marital Ther 12: 267–281.
50. Patrick D.L. Giuliano F. Ho K.F. Gagnon D.D. McNulty P. Rothman M. (2009) The Premature Ejaculation Profile: validation of self-reported outcome measures for research and practice. BJU Int 103: 358–364.
51. Patterson W. (1993) Fluoxetine induced sexual dysfunction (letter). Clin Psychiatry 54: 71–71.
52. Pattij T. Olivier B. Waldinger M.D. (1995) Animal models of ejaculatory behavior. Curr Pharm Des 11: 4069–4077.
53. Pryor J.L. Althof S.E. Steidle C. Rosen R.C. Hellstrom W.J.G. Shabsigh R. (2006) Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials. Lancet 368: 929–937.
54. Ramanathan R. Mulhall J. Rao S. Leung R. Martinez Salamanca J.I. Mandhani A. (2007) Predictive correlation between the International Index of Erectile Function (IIEF) and Sexual Health Inventory for Men (SHIM): implications for calculating a derived SHIM for clinical use. J Sexual Med 4: 1336–1344.
55. Reading A. West W. (1984) An analysis of self-reported sexual behavior in a sample of normal males. Arch Sex Behav 13: 69–83.
56. Sadeghi-Nejad H. Watson R. (2008) Continuing medical education: premature ejaculation: current medical treatment and new directions (CME). J Sexual Med 5: 1037–1050.
57. Safarinejad M.R.M.D. (2007) Safety and efficacy of escitalopram in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study. J Clin Psychopharmacol 27: 444–450.
58. Safarinejad M.R.M.D. Hosseini S.Y.M.D. (2006) Safety and efficacy of tramadol in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study. J Clin Psychopharmacol 26: 27–31.
59. Salem E.A. Wilson S.K. Bissada N.K. Delk J.R. Hellstrom W.J. Cleves M.A. (2008) ORIGINAL RESEARCH–EJACULATORY DISORDERS: Tramadol HCL has promise in on-demand use to treat premature ejaculation. J Sexual Med 5: 188–193.
60. Schapiro B. (1943) Premature ejaculation: A review of 1130 cases. J Urol 50: 374–374.
61. Segraves R. Saran A. Segraves K. Maguire E. (1993) Clomipramine versus placebo in the treatment of premature ejaculation: a pilot study. J Sex Marital Ther 19: 198–200.
62. Semans J. (1956) Premature ejaculation: a new approach. South Med J 49: 4–4.
63. Shilon M. Paz G. Homonnai Z. (1984) The use of phenoxybenzamine treatment in premature ejaculation. Fertil Steril 42: 659–661.
64. Spector I. Carey M. (1990) Incidence and prevalence of the sexual dysfunctions: A critical review of the empirical literature. Arch Sex Behav 19: 389–408.
65. Strassberg D. Brazao C.d.G. Rowland D. Tan P. Slob A. (1999) Clomipramine in the treatment of rapid (premature) ejaculation. J Sex Marital Ther 25: 89–101.
66. Symonds T. Perelman M.A. Althof S. Giuliano F. Martin M. May K. (2007) Development and validation of a premature ejaculation diagnostic tool. Eur Urol 52: 565–573.
67. Wainberg J. Buvat J. Jouaunnet P. (1984) Essai d'interpretation ontogenetique de l'ejaculation prematuree. L'ejaculation et ses perturbances Simep: Lyon-Villeurbanne, 112–116.
68. Waldinger M. Hengeveld M. Zwinderman A. Olivier B. (1998) Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. J Clin Psychopharmacol 18: 274–281.
69. Waldinger M.D. Olivier B. (2005) Animal models of premature and retarded ejaculation. World J Urol 23: 115–118.
70. Waldinger M.D. Schweitzer D.H. (2006) Changing paradigms from a historical DSM-III and DSM-IV view toward an evidence-based definition of premature ejaculation. Part II–Proposals for DSM-V and ICD-11. J Sexual Med 3: 693–705.
71. Waldinger M.D. Zwinderman A.H. Olivier B. Schweitzer D.H. (2007) The majority of men with lifelong premature ejaculation prefer daily drug treatment: an observation study in a consecutive group of Dutch men. J Sexual Med 4: 1028–1037.
72. Wang W.-F. Wang Y. Minhas S. Ralph D.J. (2007) Can sildenafil treat primary premature ejaculation? A prospective clinical study. Int J Urol 14: 331–335.
73. Xin Z.C. Choi Y.D. Lee W.H. Choi Y.J. Yang W.J. Choi H.K. (2000) Penile vibratory threshold changes with various doses of SS-cream in patients with primary premature ejaculation. Yonsei Med J 41: 29–33.
74. Yuan Y.M. Xin Z.C. Jiang H. Guo Y.J. Liu W.J. Tian L. (2004) Sexual function of premature ejaculation patients assayed with Chinese Index of Premature Ejaculation. Asian J Androl 6: 121–126.