Effect of Acute Dapoxetine Administration on the Pudendal Motoneuron Reflex in Anesthetized Rats: Comparison With Paroxetine

Journal of Urology

Volumn 177, Issue 1, 2007, Pages 386-389

  Giuliano, F ^a,b   Bernabe J ^a   Gengo, P ^c   Alexandre, L ^a   Clement P ^a  

^a Pelvipharm Laboratories   (France)

^b RAYMOND POINCARÉ HOSPITAL   (France)

^c ALZA CORPORATION   (United States)

Author keywords

dapoxetine; ejaculation; motor neurons; paroxetine; penis

Indexed keywords

DAPOXETINE; DRUG VEHICLE; PAROXETINE;

ACUTE DRUG ADMINISTRATION; AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DORSAL ROOT; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; ELECTRODE; ELECTROSTIMULATION; EXPERIMENTAL MODEL; EXPERIMENTAL RAT; MALE; NERVE STIMULATION; NONHUMAN; PENIS; PRIORITY JOURNAL; PUDENDAL MOTONEURON REFLEX; PUDENDAL NERVE; RAT; RECORDING; REFLEX; STATISTICAL SIGNIFICANCE;

ANESTHESIA; ANIMALS; BENZYLAMINES; MALE; MOTOR NEURONS; NAPHTHALENES; PAROXETINE; PENIS; RATS; RATS, WISTAR; REFLEX; SEROTONIN UPTAKE INHIBITORS;

EID: 33845288924     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2006.08.079     Document Type: Article

References (22)

1. nd International Consultation on Sexual Dysfunctions (2004), Health Publication Ltd, Oxford 37-72
2. Waldinger M.D., Hengeveld M.W., and Zwinderman A.H. Paroxetine treatment of premature ejaculation: a double-blind, randomized, placebo-controlled study. Am J Psychiatry 151 (2004) 1377
3. Kara H., Aydin S., Yucel M., Agargun M.Y., Odabas O., and Yilmaz Y. The efficacy of fluoxetine in the treatment of premature ejaculation: a double-blind placebo controlled study. J Urol 156 (1996) 1631
4. Waldinger M.D., Hengeveld M.W., Zwinderman A.H., and Olivier B. Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. J Clin Psychopharmacol 18 (1998) 274
5. McMahon C.G., and Touma K. Treatment of premature ejaculation with paroxetine hydrochloride as needed: 2 single-blind placebo controlled crossover studies. J Urol 161 (1999) 1826
6. Abdel-Hamid I.A., El Naggar E.A., and El Gilany A.H. Assessment of as needed use of pharmacotherapy and the pause-squeeze technique in premature ejaculation. Int J Impot Res 13 (2001) 41
7. Waldinger M.D., Zwinderman A.H., and Olivier B. On-demand treatment of premature ejaculation with clomipramine and paroxetine: a randomized, double-blind fixed-dose study with stopwatch assessment. Eur Urol 46 (2004) 510
8. Cantor J.M., Binik Y.M., and Pfaus J.G. Chronic fluoxetine inhibits sexual behavior in the male rat: reversal with oxytocin. Psychopharmacol 144 (1999) 355
9. Waldinger M.D., van De Plasqq A., Pattij T., van Oorschot R., Coolen L.M., Veening J.G., et al. The selective serotonin re-uptake inhibitors fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatment. Psychopharmacol 160 (2002) 283
10. Yells D.P., Prendergast M.A., Hendricks S.E., and Nakamura M. Fluoxetine-induced inhibition of male rat copulatory behavior: modification by lesions of the nucleus paragigantocellularis. Pharmacol Biochem Behav 49 (1994) 121
11. Mos J., Mollet I., Tolboom J., Waldinger M.D., and Olivier B. A comparison of the effects of different serotonin reuptake blockers on sexual behaviour of the male rat. Eur Neuropsychopharmacol 9 (1999) 123
12. Gil-Vernet Jr. J.M., Alvarez-Vijande R., Gil-Vernet A., and Gil-Vernet J.M. Ejaculation in men: a dynamic endorectal ultrasonographical study. Br J Urol 73 (1994) 442
13. Gerstenberg T.C., Levin R.J., and Wagner G. Erection and ejaculation in man. Assessment of the electromyographic activity of the bulbocavernosus and ischiocavernosus muscles. Br J Urol 65 (1990) 395
14. Truit W.A., and Coolen L.M. Identification of a potential ejaculation generator in the spinal cord. Science 297 (2002) 1566
15. Johnson R.D., and Hubscher C.H. Brainstem microstimulation differentially inhibits pudendal motoneuron reflex inputs. Neuroreport 9 (1998) 341
16. Brackett N.L., Ferrell S.M., Aballa T.C., Amador M.J., Padron O.F., Sonksen J., et al. An analysis of 653 trials of penile vibratory stimulation in men with spinal cord injury. J Urol 159 (1998) 1931
17. Lagoda G., Muschamp J.W., Vigdorchik A., and Hull E.M. A nitric oxide synthesis inhibitor in the medial preoptic area inhibits copulation and stimulus sensitization in male rats. Behav Neurosci 118 (2004) 1317
18. Maggi C.A., and Meli A. Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 1: general considerations. Experientia 42 (1986) 109
19. Chan-Palay V. Morphological correlates for transmitter synthesis, transport, release, uptake and catabolism: a study of serotonin neurons in the nucleus paragigantocellularis lateralis. In: Fonnum F. (Ed). Amino Acids as Chemical Transmitters (1978), Plenum Press, New York 1-29 Proceedings of the NATO Advanced Study Institute on Amino Acids as Chemical Transmitters held in Oslo, Norway, August 14-21, 1977.
20. Marson L., and McKenna K.E. A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes. Exp Brain Res 88 (1992) 313
21. Giuliano F., and Clement P. Physiology of ejaculation: emphasis on serotonergic control. Eur Urol 48 (2005) 408
22. Pryor J.L., Althof S.E., Steidle C., Rosen R.C., Hellstrom W.J., Shabsigh R., et al. Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials. Lancet 368 (2006) 929