Animal models of premature and retarded ejaculation

World Journal of Urology

Volumn 23, Issue 2, 2005, Pages 115-118

  Waldinger, Marcel D ^a,b   Olivier, Berend ^b,c  

^a LEYENBURG HOSPITAL   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Animal model; Premature ejaculation; Serotonin; SSRI

Indexed keywords

SEROTONIN; SEROTONIN UPTAKE INHIBITOR;

ANIMAL; ARTICLE; DISEASE MODEL; DRUG EFFECT; EJACULATION; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTION; SYNAPTIC TRANSMISSION;

ANIMALS; DISEASE MODELS, ANIMAL; EJACULATION; MALE; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SEXUAL BEHAVIOR, ANIMAL; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; SYNAPTIC TRANSMISSION;

EID: 22144434171     PISSN: 07244983     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00345-004-0493-x     Document Type: Article

References (36)

1. Rosen RC, Lane RM, Menza M (1999) Effects of SSRIs on sexual function: A critical review. J Clin Psychopharmacol 19: 67 10.1097/ 00004714-199902000-00013
2. Waldinger MD, Hengeveld MW, Zwinderman AH (1994) Paroxetine treatment of premature ejaculation: A double-blind, randomised, placebo-controlled study. Am J Psychiatry 151: 1377 1:STN:280:ByuA2cnlsVQ%3D
3. Mendels J, Camera A, Sikes C (1995) Sertraline treatment for premature ejaculation. J Clin Psychopharmacol 15: 341 10.1097/ 00004714-199510000-00006
4. Kara H, Aydin S, Agargun Y, Odabas O, Yilmiz Y (1996) The efficacy of fluoxetine in the treatment of premature ejaculation: A double-blind, placebo controlled study. J Urol 156: 1631 10.1097/ 00005392-199611000-00023
5. Waldinger MD, Zwinderman AH, Schweitzer DH, Olivier B (2004) Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: A systematic review and meta-analysis. Int J Impotence Res 16: 369 10.1038/sj.ijir.3901172
6. Larsson K, Ahlenius S (1999) Brain and sexual behavior. Ann N Y Acad Sci 877: 292 1:STN:280:DyaK1MzksVWntw%3D%3D
7. Pfaus JG (1999) Neurobiology of sexual behavior. Curr Opin Neurobiol 9: 751 10.1016/S0959-4388(99)00034-3
8. Pfaus JG, Heeb MM (1997) Implications of immediate-early gene induction in the brain following sexual stimulation of female and male rodents. Brain Res Bull 44: 397 10.1016/S0361-9230(97)00219-0
9. Veening JG, Coolen LM (1998) Neural activation following sexual behavior in the male and female rat brain. Behav Brain Res 92: 181 10.1016/ S0166-4328(97)00190-3
10. Truitt WA, Coolen LM (2002) Identification of a potential ejaculation generator in the spinal cord. Science 297: 1566 10.1126/science.1073885
11. Truitt WA, Shipley MT, Veening JG, Coolen LM (2003) Activation of a subset of lumbar spinothalamic neurons after copulatory behavior in male but not female rats. J Neurosci 23: 325 1:CAS:528:DC%2BD3sXktlagtw%3D%3D
12. Mos J, Mollet I, Tolboom JTBM, Waldinger MD, Olivier B (1999) A comparison of the effects of different serotonin reuptake blockers on sexual behaviour of the male rat. Eur Neuropsychopharmacol 9: 123 10.1016/S0924-977X(98)00015-7
13. Ahlenius S, Larsson K (1999) Synergistic actions of the 5-HT 1A antagonist WAY-100635 and citalopram on male rat ejaculatory behavior. Eur J Pharmacol 379: 1 10.1016/S0014-2999(99)00483-5
14. Matuszcyk JV, Larsson K, Eriksson E (1998) The selective serotonin reuptake inhibitor fluoxetine reduces sexual motivation in male rats. Pharmacol Biochem Behav 60: 527 10.1016/S0091-3057(98)00010-0
15. Cantor J, Binik I, Pfaus JG (1999) Chronic fluoxetine inhibits sexual behavior in the male rat: Reversal with oxytocin. Psychopharmacology 144: 355 10.1007/s002130051018
16. Frank JL, Hendricks SE, Olson CH (2000) Multiple ejaculations and chronic fluoxetine: Effects on male rat copulatory behavior. Pharmacol Biochem Behav 66: 337 10.1016/S0091-3057(00)00191-X
17. Waldinger MD, Plas A vd, Pattij T, Oorschot R v, Coolen LM, Veening JG, Olivier B (2002) The selective serotonin re-uptake inhibitors fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatment. Psychopharmacology 160: 283 10.1007/s00213-001-0980-3
18. Waldinger MD, Schweitzer DH, Olivier B (2005) On-demand SSRI treatment of premature ejaculation: Pharmacodynamic limitations for relevant ejaculation delay and consequent solutions. J Sex Med 2: 121 10.1111/ j.1743-6109.2005.20112.x
19. Bitran D, Hull EM (1987) Pharmacological analysis of male rat sexual behavior. Neurosci Biobehav Rev 11: 365
20. Argiolas A (1999) Neuropeptides and sexual behaviour. Neurosci Biobehav Rev 23: 1127
21. 3antagonists and benzodiazepines: Their comparative behavioural pharmacology. John Wiley, Chichester, p 281
22. Mos J, Olivier B, Bloetjes K, Poth M (1990) In: Slob AK, Baum MJ (eds) Psychoneuroendocrinology of growth and development. Medicom Publishers, Rotterdam, p 221
23. 2 antagonistic properties, on male-rat sexual-behavior. Eur J Pharmacol 255: 131 10.1016/0014-2999(94)90091-4
24. Haensel SM, Slob AK (1997) Flesinoxan: A prosexual drug for male rats. Eur J Pharmacol 330: 1 10.1016/S0014-2999(97)00170-2
25. Ferrari F, Giuliani D (1994) The selective D-2 dopamine-receptor antagonist eticlopride counteracts the ejaculatio-praecox induced by the selective D-2-dopamine agonist SND-919 in the rat. Life Sci 55: 1155 10.1016/0024-3205(94)00244-4
26. Barfield RJ, Sachs BD (1968) Sexual behavior: Stimulation by painful electrical shock to skin in male rats. Science 161: 392 1:STN:280:CCeA383mtVw%3D
27. Wang L, Hull EM (1980) Tail pinch induces sexual behavior in olfactory bulbectomized male rats. Physiol Behav 24: 211 10.1016/ 0031-9384(80)90076-1
28. Leyton M, Stewart J (1996) Acute and repeated activation of male sexual behavior by tail pinch: Opioid and dopaminergic mechanisms. Physiol Behav 60: 77 10.1016/0031-9384(95)02270-8
29. Waldinger MD, Berendsen HHG, Blok BFM, Olivier B, Holstege G (1998) Premature ejaculation and SSRI-induced delayed ejaculation: The involvement of the serotonergic system. Behav Brain Res 92: 111 10.1016/ S0166-4328(97)00183-6
30. Waldinger MD, Schweitzer DH (2005) Lifelong premature ejaculation: definition, serotonergic neurotransmission and drug treatment. World J Urol (this issue)
31. Waldinger MD, Quinn P, Dilleen M, Mundayat R, Schweitzer DH, Boolell M (2005) A multinational population survey of intravaginal ejaculation latency time. J Sex Med (in press)
32. Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH (2005) Proposal for a definition of lifelong premature ejaculation based on epidemiological stopwatch data. J Sex Med (in press)
33. Olivier B, Chan J, Pattij T, De Jong T, Oosting R, Veening J, Waldinger MD (2005) Psychopharmacology of male rat sexual behavior: Modeling human sexual dysfunctions? Int J Impot Res (in press)
34. Pattij T, De Jong T, Uitterdijk A, Waldinger MD, Veening JG, Van der Graaf PH, Olivier B (2005) Searching for models to study ejaculation disorders. Eur J Neurosci (in press)
35. Rowland DL (1998) Penile sensitivity in men: A composite of recent findings. Urology 52: 1101 10.1016/S0090-4295(98)00413-0
36. Agmo A (1999) Sexual motivation-an inquiry into events determining the occurrence of sexual behavior. Behav Brain Res 105: 129 10.1016/ S0166-4328(99)00088-1