Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence

Molecular Psychiatry

Volumn 16, Issue 11, 2011, Pages 1139-1146

  Enoch, M A ^a   Gorodetsky, E ^b   Hodgkinson, C ^a   Roy, A ^c   Goldman, D ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

5 HTTLPR; alcoholism; cocaine; heroin; HTR3B; rs1176744

Indexed keywords

DOPAMINE; SERINE; SEROTONIN; SEROTONIN 3 RECEPTOR; SEROTONIN TRANSPORTER; TYROSINE;

AFRICAN AMERICAN; ALCOHOLISM; ALLELE; ARTICLE; COCAINE DEPENDENCE; COMORBIDITY; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DOPAMINERGIC TRANSMISSION; GAIN OF FUNCTION MUTATION; GENE FREQUENCY; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HELP SEEKING BEHAVIOR; HEROIN DEPENDENCE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHARMACOGENETICS; PREDICTIVE VALUE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SYNAPSE;

ADULT; AFRICAN AMERICANS; ALCOHOLISM; ALLELES; COCAINE-RELATED DISORDERS; COMORBIDITY; DOPAMINE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HEROIN DEPENDENCE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, SEROTONIN, 5-HT3; REWARD; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 80054850501     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2010.94     Document Type: Article

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