Advances on aptamers targeting plasmodium and trypanosomatids

Current Medicinal Chemistry

Volumn 18, Issue 32, 2011, Pages 5003-5010

  Moreno, M ^a   Gonzalez V M ^b  

^a CENTRO DE ASTROBIOLOGÍA CSIC INTA   (Spain)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

Aptamer; Diagnosis; Leishmania; Parasite; Plasmodium; RNA; SELEX; SsDNA; Therapeutic; Trypanosoma

Indexed keywords

2' AMMONIA MODIFIED RNA APTAMER; ALLOPURINOL; AMPHOTERICIN B; APTAMER; AZITHROMYCIN; BENZNIDAZOLE; DAPSONE; ERYTHROCYTE MEMBRANE PROTEIN 1; F4 APTAMER; FIBRONECTIN; HEPARAN SULFATE; HISTONE H2A; HS6 APTAMER; L28 APTAMER; LAMININ; MEGLUMINE ANTIMONATE; MELARSOPROL; MILTEFOSINE; NIFURTIMOX; PAROMOMYCIN; PENTAMIDINE; POSACONAZOLE; QUINOLINE DERIVATIVE; RAVUCONAZOLE; RIFAMPICIN; STIBOGLUCONATE SODIUM; SURAMIN; T6 APTAMER; THROMBOSPONDIN; TRYBIZINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CHAGAS DISEASE; DNA LIBRARY; DRUG DELIVERY SYSTEM; DRUG TARGETING; EXTRACELLULAR MATRIX; HUMAN; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; KINETOPLASTIDA; LEISHMANIA INFANTUM; LEISHMANIASIS; MALARIA; MALARIA CONTROL; NONHUMAN; PLASMODIUM; PLASMODIUM FALCIPARUM; TRYPANOSOMA; TRYPANOSOMIASIS; UNSPECIFIED SIDE EFFECT;

ANIMALS; ANTIMALARIALS; APTAMERS, NUCLEOTIDE; HUMANS; MALARIA; PLASMODIUM; TRYPANOSOMATINA;

EID: 80054848436     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986711797535218     Document Type: Article

References (60)

1. Collier, R., WHO reports progress in malaria control. CMAJ, 2010, 182, E105-106.
2. Lescure, F.X.; Le Loup, G.; Freilij, H.; Develoux, M.; Paris, L.; Brutus, L.; Pialoux, G., Chagas disease: Changes in knowledge and management. Lancet Infect Dis, 2010, 10, 556-570.
3. Murray, H.W.; Berman, J.D.; Davies, C.R.; Saravia, N.G., Advances in leishmaniasis. Lancet, 2005, 366, 1561-1577. (Pubitemid 41540115)
4. Schwartz, E.; Hatz, C.; Blum, J., New world cutaneous leishmaniasis in travellers. Lancet Infect Dis, 2006, 6, 342-349. (Pubitemid 43737272)
5. Sadanand, S., Malaria: An evaluation of the current state of research on pathogenesis and antimalarial drugs. Yale J Biol Med, 2010, 83, 185-191.
6. Goto, H.; Lindoso, J.A., Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. Expert Rev Anti Infect Ther, 2010, 8, 419-433.
7. Ashley, E.A.; White, N.J., Artemisinin-based combinations. Current Opinion in Infectious Diseases, 2005, 18, 531-536. (Pubitemid 41634767)
8. Day, N.P.J.; Hien, T.T.; Schollaardt, T.; Loc, P.P.; Chuong, L.V.; Hong Chau, T.T.; Hoang Mai, N.T.; Phu, N.H.; Sinh, D.X.; White, N.J.; Ho, M., The Prognostic and Pathophysiologic Role of Pro-and Antiinflammatory Cytokines in Severe Malaria. Journal of Infectious Diseases, 1999, 180, 1288-1297. (Pubitemid 30070216)
9. White, N.J., Preventing antimalarial drug resistance through combinations. Drug Resistance Updates, 1998, 1, 3-9.
10. Santos, D.O.; Coutinho, C.E.; Madeira, M.F.; Bottino, C.G.; Vieira, R.T.; Nascimento, S.B.; Bernardino, A.; Bourguignon, S.C.; Corte-Real, S.; Pinho, R.T.; Rodrigues, C.R.; Castro, H.C., Leishmaniasis treatment-a challenge that remains: A review. Parasitol Res, 2008, 103, 1-10.
11. Moll, K.; Chane, A.; Ribacke, U.; Kaneko, O.; Nilsson, S.; Winter, G.; Haeggstrm, M.; Pan, W.; Berzins, K.; Wahlgren, M.; Chen, Q., A Novel DBL-Domain of the P. falciparum 332 Molecule Possibly Involved in Erythrocyte Adhesion. PLoS ONE, 2007, 2, e477.
12. Triglia, T.; Healer, J.; Caruana, S.R.; Hodder, A.N.; Anders, R.F.; Crabb, B.S.; Cowman, A.F., Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species. Molecular Microbiology, 2000, 38, 706-718.
13. Normark, J.; Nilsson, D.; Ribacke, U.; Winter, G.; Moll, K.; Wheelock, C.E.; Bayarugaba, J.; Kironde, F.; Egwang, T.G.; Chen, Q.; Andersson, B.r.; Wahlgren, M., PfEMP1-DBL1± amino acid motifs in severe disease states of Plasmodium falciparum malaria. Proceedings of the National Academy of Sciences, 2007, 104, 15835-15840. (Pubitemid 350035385)
14. Ahuja, S.; Pettersson, F.; Moll, K.; Jonsson, C.; Wahlgren, M.; Chen, Q., Induction of cross-reactive immune responses to NTS-DBL-1[alpha]/x of PfEMP1 and in vivo protection on challenge with Plasmodium falciparum. Vaccine, 2006, 24, 6140-6154. (Pubitemid 44175616)
15. Burri, C., Chemotherapy against human African trypanosomiasis: Is there a road to success? Parasitology, 2010, 137, 1987-1994.
16. Magez, S.; Radwanska, M., African trypanosomiasis and antibodies: Implications for vaccination, therapy and diagnosis. Future Microbiol, 2009, 4, 1075-1087.
17. Marin-Neto, J.A.; Rassi Jr., A.; Morillo, C.A.; Avezum, A.; Connolly, S.J.; Sosa-Estani, S.; Rosas, F.; Yusuf, S., Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: The BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT). American Heart Journal, 2008, 156, 37-43. (Pubitemid 351862295)
18. Keefe, A.D.; Pai, S.; Ellington, A., Aptamers as therapeutics. Nat Rev Drug Discov, 2010, 9, 537-550.
19. Ellington, A.D.; Szostak, J.W., In vitro selection of RNA molecules that bind specific ligands. Nature, 1990, 346, 818-822.
20. Tuerk, C.; Gold, L., Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science, 1990, 249, 505-510.
21. Stoltenburg, R.; Reinemann, C.; Strehlitz, B., SELEX-a (r)evolutionary method to generate high-affinity nucleic acid ligands. Biomol Eng, 2007, 24, 381-403. (Pubitemid 47391579)
22. Gold, L.; Polisky, B.; Uhlenbeck, O.; Yarus, M., Diversity of oligonucleotide functions. Annu Rev Biochem, 1995, 64, 763-797.
23. Proske, D.; Blank, M.; Buhmann, R.; Resch, A., Aptamers-basic research, drug development, and clinical applications. Appl Microbiol Biotechnol, 2005, 69, 367-374. (Pubitemid 41737059)
24. Sampson, T., Aptamers and SELEX: The technology. World Patent Information, 2003, 25, 123-129. (Pubitemid 36452696)
25. Marton, S.; Reyes-Darias, J.A.; Sanchez-Luque, F.J.; Romero-Lopez, C.; Berzal-Herranz, A., In vitro and ex vivo selection procedures for identifying potentially therapeutic DNA and RNA molecules. Molecules, 2010, 15, 4610-4638.
26. Yang, X.; Li, N.; Gorenstein, D.G., Strategies for the discovery of therapeutic aptamers. Expert Opinion on Drug Discovery, 2011, 6, 75-87.
27. Bouchard, P.R.; Hutabarat, R.M.; Thompson, K.M., Discovery and Development of Therapeutic Aptamers. Annual Review of Pharmacology and Toxicology, 2010, 50, 237-257.
28. White, R.R.; Sullenger, B.A.; Rusconi, C.P., Developing aptamers into therapeutics. J Clin Invest, 2000, 106, 929-934.
29. Ulrich, H.; Trujillo, C.A.; Nery, A.A.; Alves, J.M.; Majumder, P.; Resende, R.R.; Martins, A.H., DNA and RNA aptamers: From tools for basic research towards therapeutic applications. Comb Chem High Throughput Screen, 2006, 9, 619-632. (Pubitemid 44320411)
30. Jenison, R.D.; Jennings, S.D.; Walker, D.W.; Bargatze, R.F.; Parma, D., Oligonucleotide inhibitors of P-selectin-dependent neutrophil-platelet adhesion. Antisense Nucleic Acid Drug Dev, 1998, 8, 265-279. (Pubitemid 28446114)
31. Kubik, M.F.; Stephens, A.W.; Schneider, D.; Marlar, R.A.; Tasset, D., Highaffinity RNA ligands to human alpha-thrombin. Nucleic Acids Res, 1994, 22, 2619-2626. (Pubitemid 24222442)
32. Lin, Y.; Padmapriya, A.; Morden, K.M.; Jayasena, S.D., Peptide conjugation to an in vitro-selected DNA ligand improves enzyme inhibition. Proc Natl Acad Sci U S A, 1995, 92, 11044-11048.
33. Barfod, A.; Persson, T.; Lindh, J., In vitro selection of RNA aptamers against a conserved region of the Plasmodium falciparum erythrocyte membrane protein 1. Parasitology Research, 2009, 105, 1557-1566.
34. Francis, S.E.; Sullivan, D.J., Jr.; Goldberg, D.E., Hemoglobin metabolism in the malaria parasite Plasmodium falciparum. Annu Rev Microbiol, 1997, 51, 97-123. (Pubitemid 27433044)
35. Niles, J.C.; DeRisi, J.L.; Marletta, M.A., Inhibiting Plasmodium falciparum growth and heme detoxification pathway using heme-binding DNA aptamers. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106, 13266-13271.
36. Li, Y.; Geyer, C.R.; Sen, D., Recognition of anionic porphyrins by DNA aptamers. Biochemistry, 1996, 35, 6911-6922. (Pubitemid 26172449)
37. Okazawa, A.; Maeda, H.; Fukusaki, E.; Katakura, Y.; Kobayashi, A., In vitro selection of hematoporphyrin binding DNA aptamers. Bioorg Med Chem Lett, 2000, 10, 2653-2656.
38. Homann, M.; Goringer, H.U., Combinatorial selection of high affinity RNA ligands to live African trypanosomes. Nucleic Acids Research, 1999, 27, 2006-2014. (Pubitemid 29209561)
39. Homann, M.; Goringer, H.U., Uptake and intracellular transport of RNA aptamers in African trypanosomes suggest therapeutic "piggy-back" approach. Bioorganic & Medicinal Chemistry, 2001, 9, 2571-2580. (Pubitemid 32824160)
40. Adler, A.; Forster, N.; Homann, M.; Goringer, H.U., Post-SELEX chemical optimization of a trypanosome-specific RNA aptamer. Combinatorial Chemistry & High Throughput Screening, 2008, 11, 16-23.
41. Homann, M.; Lorger, M.; Engstler, M.; Zacharias, M.; Goringer, H.U., Serum-stable RNA aptamers to an invariant surface domain of live African trypanosomes. Combinatorial Chemistry & High Throughput Screening, 2006, 9, 491-499. (Pubitemid 44156707)
42. Lorger, M.; Engstler, M.; Homann, M.; Goringer, H.U., Targeting the variable surface of African trypanosomes with variant surface glycoproteinspecific, serum-stable RNA aptamers. Eukaryotic Cell, 2003, 2, 84-94. (Pubitemid 36770378)
43. Ulrich, H.; Magdesian, M.H.; Alves, M.J.M.; Colli, W., In vitro selection of RNA aptamers that bind to cell adhesion receptors of Trypanosoma cruzi and inhibit cell invasion. Journal of Biological Chemistry, 2002, 277, 20756-20762. (Pubitemid 34967381)
44. Goncçalves, M.F.; Umezawa, E.S.; Katzin, A.M.; de Souza, W.; Alves, M.J.M.; Zingales, B.; Colli, W., Trypanosoma cruzi: Shedding of surface antigens as membrane vesicles. Experimental Parasitology, 1991, 72, 43-53.
45. Goringer, H.U.; Homann, M.; Lorger, M., In vitro selection of high-affinity nucleic acid ligands to parasite target molecules. International Journal for Parasitology, 2003, 33, 1309-1317. (Pubitemid 37176976)
46. Goringer, H.U.; Homann, M.; Zacharias, M.; Adler, A., RNA aptamers as potential pharmaceuticals against infections with African trypanosomes. Handb Exp Pharmacol, 2006, 375-393.
47. Neryl, A.A.; Wrenger, C.; Ulrich, H., Recognition of biomarkers and cellspecific molecular signatures: Aptamers as capture agents. Journal of Separation Science, 2009, 32, 1523-1530.
48. Ramos, E.; Pineiro, D.; Soto, M.; Abanades, D.R.; Martin, M.E.; Salinas, M.; Gonzalez, V.M., A DNA aptamer population specifically detects Leishmania infantum H2A antigen. Laboratory Investigation, 2007, 87, 409-416. (Pubitemid 46633125)
49. Ramos, E.; Moreno, M.; Martn, M.E.; Soto, M.; Gonzalez, V.M., In vitro Selection of Leishmania infantum H3-Binding ssDNA Aptamers. Oligonucleotides, 2010, 20, 207-213.
50. Requena, J.M.; Alonso, C.; Soto, M., Evolutionarily Conserved Proteins as Prominent Immunogens during Leishmania Infections. Parasitology Today, 2000, 16, 246-250. (Pubitemid 30332127)
51. Soto, M.; Requena, J.M.; Quijada, L.; Alonso, C., Multicomponent chimeric antigen for serodiagnosis of canine visceral leishmaniasis. J Clin Microbiol, 1998, 36, 58-63. (Pubitemid 28047433)
52. Bhattacharyya, S.N.; Chatterjee, S.; Adhya, S., Mitochondrial RNA Import in Leishmania tropica: Aptamers Homologous to Multiple tRNA Domains That Interact Cooperatively or Antagonistically at the Inner Membrane. Mol. Cell. Biol., 2002, 22, 4372-4382. (Pubitemid 34556604)
53. Rubio, M.A.; Liu, X.; Yuzawa, H.; Alfonzo, J.D.; Simpson, L., Selective importation of RNA into isolated mitochondria from Leishmania tarentolae. RNA, 2000, 6, 988-1003. (Pubitemid 30471136)
54. Schneider, A.; Martin, J.; Agabian, N., A nuclear encoded tRNA of Trypanosoma brucei is imported into mitochondria. Mol. Cell. Biol., 1994, 14, 2317-2322. (Pubitemid 24108213)
55. Mahapatra, S.; Adhya, S., Import of RNA into Leishmania Mitochondria Occurs through Direct Interaction with Membrane-bound Receptors. Journal of Biological Chemistry, 1996, 271, 20432-20437. (Pubitemid 26281813)
56. Kolesnikova, O.; Kazakova, H.; Comte, C.; Steinberg, S.; Kamenski, P.; Martin, R.P.; Tarassov, I.; Entelis, N., Selection of RNA aptamers imported into yeast and human mitochondria. RNA, 2010, 16, 926-941.
57. Moreno, M.; Rincon, E.; Pineiro, D.; Fernandez, G.; Domingo, A.; Jimenez-Ruiz, A.; Salinas, M.; Gonzalez, V.M., Selection of aptamers against KMP-11 using colloidal gold during the SELEX process. Biochemical and Biophysical Research Communications, 2003, 308, 214-218. (Pubitemid 36937168)
58. Moreno, M.; Gonzalez, V.M.; Rincon, E.; Domingo, A.; Dominguez, E., Aptasensor based on the selective electrodeposition of protein-linked gold nanoparticles on screen-printed electrodes. Analyst, 2011, 136, 1810-1815.
59. Ulrich, H.; Wrenger, C., Disease-Specific Biomarker Discovery by Aptamers. Cytometry Part A, 2009, 75A, 727-733.
60. Pecoul, B.; Chirac, P.; Trouiller, P.; Pinel, J., Access to Essential Drugs in Poor Countries: A Lost Battle? JAMA, 1999, 281, 361-367. (Pubitemid 29061041)