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Volumn 33, Issue 12, 2003, Pages 1309-1317

In vitro selection of high-affinity nucleic acid ligands to parasite target molecules

Author keywords

African trypanosome; Aptamer; Combinatorial chemistry; In vitro evolution; SELEX; Systematic evolution of ligands by exponential enrichment; Trypanosoma cruzi

Indexed keywords

APTAMER; LIGAND; NUCLEIC ACID;

EID: 0141756136     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(03)00197-8     Document Type: Article
Times cited : (41)

References (73)
  • 1
    • 0037453505 scopus 로고    scopus 로고
    • Developing drugs for parasitic diseases
    • Andreopoulos S. Developing drugs for parasitic diseases. Science. 300:2003;430-431.
    • (2003) Science , vol.300 , pp. 430-431
    • Andreopoulos, S.1
  • 2
    • 0036582060 scopus 로고    scopus 로고
    • Perspectives for new drugs against trypanosomiasis and leishmaniasis
    • Barrett M.P., Gilbert I.H. Perspectives for new drugs against trypanosomiasis and leishmaniasis. Curr. Top. Med. Chem. 2:2002;471-482.
    • (2002) Curr. Top. Med. Chem. , vol.2 , pp. 471-482
    • Barrett, M.P.1    Gilbert, I.H.2
  • 3
    • 0036603595 scopus 로고    scopus 로고
    • Recent advances in the in vitro evolution of nucleic acids
    • Bittker J.A., Phillips K.J., Liu D.R. Recent advances in the in vitro evolution of nucleic acids. Curr. Opin. Chem. Biol. 6:2002;367-374.
    • (2002) Curr. Opin. Chem. Biol. , vol.6 , pp. 367-374
    • Bittker, J.A.1    Phillips, K.J.2    Liu, D.R.3
  • 4
    • 0027412486 scopus 로고
    • A structural motif in the variant surface glycoproteins of Trypanosoma brucei
    • Blum M.L., Down J.A., Gurnett A.M., Carrington M., Turner M.J., Wiley D.C. A structural motif in the variant surface glycoproteins of Trypanosoma brucei. Nature. 362:1993;603-609.
    • (1993) Nature , vol.362 , pp. 603-609
    • Blum, M.L.1    Down, J.A.2    Gurnett, A.M.3    Carrington, M.4    Turner, M.J.5    Wiley, D.C.6
  • 5
    • 0026575221 scopus 로고
    • Selection of single-stranded DNA molecules that bind and inhibit human thrombin
    • Bock L.C., Griffin L.C., Latham J.A., Vermaas E.H., Toole J.J. Selection of single-stranded DNA molecules that bind and inhibit human thrombin. Nature. 355:1992;564-566.
    • (1992) Nature , vol.355 , pp. 564-566
    • Bock, L.C.1    Griffin, L.C.2    Latham, J.A.3    Vermaas, E.H.4    Toole, J.J.5
  • 6
    • 0031726222 scopus 로고    scopus 로고
    • Surface receptors and transporters of Trypanosoma brucei
    • Borst P., Fairlamb A.H. Surface receptors and transporters of Trypanosoma brucei. Annu. Rev. Microbiol. 52:1998;745-778.
    • (1998) Annu. Rev. Microbiol. , vol.52 , pp. 745-778
    • Borst, P.1    Fairlamb, A.H.2
  • 7
    • 0005620475 scopus 로고    scopus 로고
    • Aptamers as therapeutic and diagnostic agents
    • Brody E.N., Gold L. Aptamers as therapeutic and diagnostic agents. J. Biotechnol. 74:2000;5-13.
    • (2000) J. Biotechnol. , vol.74 , pp. 5-13
    • Brody, E.N.1    Gold, L.2
  • 9
    • 0037114941 scopus 로고    scopus 로고
    • Aptamers as tools for target prioritization and lead identification
    • Burgstaller P., Girod A., Blind M. Aptamers as tools for target prioritization and lead identification. Drug Discov. Today. 7:2002;1221-1228.
    • (2002) Drug Discov. Today , vol.7 , pp. 1221-1228
    • Burgstaller, P.1    Girod, A.2    Blind, M.3
  • 10
    • 0036330049 scopus 로고    scopus 로고
    • Vaccine development against schistosomiasis from concepts to clinical trials
    • Capron A., Capron M., Riveau G. Vaccine development against schistosomiasis from concepts to clinical trials. Br. Med. Bull. 62:2002;139-148.
    • (2002) Br. Med. Bull. , vol.62 , pp. 139-148
    • Capron, A.1    Capron, M.2    Riveau, G.3
  • 11
    • 0022144562 scopus 로고
    • Gene synthesis machines: DNA chemistry and its uses
    • Caruthers M.H. Gene synthesis machines: DNA chemistry and its uses. Science. 230:1985;281-285.
    • (1985) Science , vol.230 , pp. 281-285
    • Caruthers, M.H.1
  • 13
    • 0016809286 scopus 로고
    • Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei
    • Cross G.A.M. Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei. Parasitology. 71:1975;393-417.
    • (1975) Parasitology , vol.71 , pp. 393-417
    • Cross, G.A.M.1
  • 14
    • 0030131182 scopus 로고    scopus 로고
    • Antigenic variation in trypanosomes: Secrets surface slowly
    • Cross G.A.M. Antigenic variation in trypanosomes: secrets surface slowly. Bioassays. 18:1996;283-291.
    • (1996) Bioassays , vol.18 , pp. 283-291
    • Cross, G.A.M.1
  • 15
    • 0029890880 scopus 로고    scopus 로고
    • Identifying consensus patterns and secondary structure in SELEX sequence sets
    • Davis J.P., Janjic N., Javornik B.E., Zichi D.A. Identifying consensus patterns and secondary structure in SELEX sequence sets. Methods Enzymol. 267:1996;302-314.
    • (1996) Methods Enzymol. , vol.267 , pp. 302-314
    • Davis, J.P.1    Janjic, N.2    Javornik, B.E.3    Zichi, D.A.4
  • 16
    • 0020655657 scopus 로고
    • The membrane form of variant surface glycoproteins of Trypanosoma brucei
    • De Almeida M.L.C., Turner M.J. The membrane form of variant surface glycoproteins of Trypanosoma brucei. Exp. Nature. 302:1983;349-352.
    • (1983) Exp. Nature , vol.302 , pp. 349-352
    • De Almeida, M.L.C.1    Turner, M.J.2
  • 18
    • 0036637084 scopus 로고    scopus 로고
    • The impact of Chagas disease control in Latin America: A review
    • Dias J.C., Silveira A.C., Schofield C.J. The impact of Chagas disease control in Latin America: a review. Mem. Inst. Oswaldo Cruz. 97:2002;603-612.
    • (2002) Mem. Inst. Oswaldo Cruz , vol.97 , pp. 603-612
    • Dias, J.C.1    Silveira, A.C.2    Schofield, C.J.3
  • 19
    • 0035342334 scopus 로고    scopus 로고
    • Bisphosphonates as chemotherapeutic agents against trypanosomatid and apicomplexan parasites
    • Docampo R., Moreno S.N. Bisphosphonates as chemotherapeutic agents against trypanosomatid and apicomplexan parasites. Curr. Drug Targets Infect. Disord. 1:2001;51-61.
    • (2001) Curr. Drug Targets Infect. Disord. , vol.1 , pp. 51-61
    • Docampo, R.1    Moreno, S.N.2
  • 24
    • 0025074907 scopus 로고
    • In vitro selection of RNA molecules that bind specific ligands
    • Ellington A.D., Szostak J.W. In vitro selection of RNA molecules that bind specific ligands. Nature. 346:1990;818-822.
    • (1990) Nature , vol.346 , pp. 818-822
    • Ellington, A.D.1    Szostak, J.W.2
  • 26
    • 0025194450 scopus 로고
    • 2.9 Å resolution structure of the N-terminal domain of a variant surface glycoprotein from Trypanosoma brucei
    • Freymann D., Down J., Carrington M., Roditi I., Turner M., Wiley D. 2.9 Å resolution structure of the N-terminal domain of a variant surface glycoprotein from Trypanosoma brucei. J. Mol. Biol. 216:1990;141-160.
    • (1990) J. Mol. Biol. , vol.216 , pp. 141-160
    • Freymann, D.1    Down, J.2    Carrington, M.3    Roditi, I.4    Turner, M.5    Wiley, D.6
  • 28
    • 0033524911 scopus 로고    scopus 로고
    • Cloning of a surface membrane glycoprotein specific for the infective form of Trypanosoma cruzi having adhesive properties to laminin
    • Giordano R., Fouts D.L., Tewari D., Colli W., Manning J.E., Alves M.J. Cloning of a surface membrane glycoprotein specific for the infective form of Trypanosoma cruzi having adhesive properties to laminin. J. Biol. Chem. 274:1999;3461-3468.
    • (1999) J. Biol. Chem. , vol.274 , pp. 3461-3468
    • Giordano, R.1    Fouts, D.L.2    Tewari, D.3    Colli, W.4    Manning, J.E.5    Alves, M.J.6
  • 29
    • 0029031094 scopus 로고
    • Oligonucleotides as research, diagnostic, and therapeutic agents
    • Gold L. Oligonucleotides as research, diagnostic, and therapeutic agents. J. Biol. Chem. 270:1995;13581-13584.
    • (1995) J. Biol. Chem. , vol.270 , pp. 13581-13584
    • Gold, L.1
  • 32
    • 0035010462 scopus 로고    scopus 로고
    • Aptamers as reagents for high-throughput screening
    • Green L.S., Bell C., Janjic N. Aptamers as reagents for high-throughput screening. Biotechniques. 30:2001;1094-1110.
    • (2001) Biotechniques , vol.30 , pp. 1094-1110
    • Green, L.S.1    Bell, C.2    Janjic, N.3
  • 33
    • 0027163099 scopus 로고
    • In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits
    • Griffin L.C., Tidmarsh G.F., Bock L.C., Toole J.J., Leung L.L. In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits. Blood. 81:1993;3271-3276.
    • (1993) Blood , vol.81 , pp. 3271-3276
    • Griffin, L.C.1    Tidmarsh, G.F.2    Bock, L.C.3    Toole, J.J.4    Leung, L.L.5
  • 34
    • 0034603154 scopus 로고    scopus 로고
    • Adaptive recognition by nucleic acid aptamers
    • Hermann T., Patel D.J. Adaptive recognition by nucleic acid aptamers. Science. 287:2000;820-825.
    • (2000) Science , vol.287 , pp. 820-825
    • Hermann, T.1    Patel, D.J.2
  • 35
    • 0027936004 scopus 로고
    • Mediation of Trypanosoma cruzi invasion by heparan sulfate receptors on host cells and penetrin counter-receptors on the trypanosomes
    • Herrera E.M., Ming M., Ortega-Barria E., Pereira M.E. Mediation of Trypanosoma cruzi invasion by heparan sulfate receptors on host cells and penetrin counter-receptors on the trypanosomes. Mol. Biochem. Parasitol. 65:1994;73-83.
    • (1994) Mol. Biochem. Parasitol. , vol.65 , pp. 73-83
    • Herrera, E.M.1    Ming, M.2    Ortega-Barria, E.3    Pereira, M.E.4
  • 37
    • 0344690107 scopus 로고    scopus 로고
    • Combinatorial selection of high affinity RNA ligands to live African trypanosomes
    • Homann M., Göringer H.U. Combinatorial selection of high affinity RNA ligands to live African trypanosomes. Nucleic Acids Res. 27:1999;2006-2014.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 2006-2014
    • Homann, M.1    Göringer, H.U.2
  • 38
    • 0034841963 scopus 로고    scopus 로고
    • Uptake and intracellular transport of RNA aptamers in African trypanosomes suggest therapeutic 'piggy-back' approach
    • Homann M., Göringer H.U. Uptake and intracellular transport of RNA aptamers in African trypanosomes suggest therapeutic 'piggy-back' approach. Bioorg. Med. Chem. 9:2001;2571-2580.
    • (2001) Bioorg. Med. Chem. , vol.9 , pp. 2571-2580
    • Homann, M.1    Göringer, H.U.2
  • 39
    • 0027375727 scopus 로고
    • Structural analysis by energy dot plot of a large mRNA
    • Jacobson A.B., Zuker M. Structural analysis by energy dot plot of a large mRNA. J. Mol. Biol. 233:1993;261-269.
    • (1993) J. Mol. Biol. , vol.233 , pp. 261-269
    • Jacobson, A.B.1    Zuker, M.2
  • 40
    • 0032860385 scopus 로고    scopus 로고
    • Aptamers: An emerging class of molecules that rival antibodies in diagnostics
    • Jayasena S.D. Aptamers: an emerging class of molecules that rival antibodies in diagnostics. Clin. Chem. 45:1999;1628-1650.
    • (1999) Clin. Chem. , vol.45 , pp. 1628-1650
    • Jayasena, S.D.1
  • 41
    • 0018791006 scopus 로고
    • Selective cleavage of variant surface glycoproteins from Trypanosoma brucei
    • Johnson J.G., Cross G.A. Selective cleavage of variant surface glycoproteins from Trypanosoma brucei. Biochem. J. 178:1979;689-697.
    • (1979) Biochem. J. , vol.178 , pp. 689-697
    • Johnson, J.G.1    Cross, G.A.2
  • 42
  • 43
    • 0036603953 scopus 로고    scopus 로고
    • From combinatorial chemistry to chemical microarray
    • Lam K.S., Renil M. From combinatorial chemistry to chemical microarray. Curr. Opin. Chem. Biol. 6:2002;353-358.
    • (2002) Curr. Opin. Chem. Biol. , vol.6 , pp. 353-358
    • Lam, K.S.1    Renil, M.2
  • 45
    • 0037862005 scopus 로고    scopus 로고
    • Targeting the variable surface of African trypanosomes using VSG-specific, serum-stable RNA aptamers
    • Lorger M., Engstler M., Homann M., Göringer H.U. Targeting the variable surface of African trypanosomes using VSG-specific, serum-stable RNA aptamers. Eukaryot. Cell. 2:2003;84-94.
    • (2003) Eukaryot. Cell , vol.2 , pp. 84-94
    • Lorger, M.1    Engstler, M.2    Homann, M.3    Göringer, H.U.4
  • 48
    • 0036861169 scopus 로고    scopus 로고
    • The kinetoplastida endocytic apparatus. Part I: A dynamic system for nutrition and evasion of host defences
    • Morgan G.W., Hall B.S., Denny P.W., Carrington M., Field M.C. The kinetoplastida endocytic apparatus. Part I: a dynamic system for nutrition and evasion of host defences. Trends Parasitol. 18:2002;491-496.
    • (2002) Trends Parasitol. , vol.18 , pp. 491-496
    • Morgan, G.W.1    Hall, B.S.2    Denny, P.W.3    Carrington, M.4    Field, M.C.5
  • 49
    • 0036898661 scopus 로고    scopus 로고
    • The endocytic apparatus of the kinetoplastida. Part II: Machinery and components of the system
    • Morgan G.W., Hall B.S., Denny P.W., Field M.C., Carrington M. The endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system. Trends Parasitol. 18:2002;540-546.
    • (2002) Trends Parasitol. , vol.18 , pp. 540-546
    • Morgan, G.W.1    Hall, B.S.2    Denny, P.W.3    Field, M.C.4    Carrington, M.5
  • 52
    • 0022978735 scopus 로고
    • Trypanosoma cruzi infection inhibited by peptides modeled from a fibronectin cell attachment domain
    • Ouaissi M.A., Cornette J., Afchain D., Capron A., Gras-Masse H., Tartar A. Trypanosoma cruzi infection inhibited by peptides modeled from a fibronectin cell attachment domain. Science. 234:1986;603-607.
    • (1986) Science , vol.234 , pp. 603-607
    • Ouaissi, M.A.1    Cornette, J.2    Afchain, D.3    Capron, A.4    Gras-Masse, H.5    Tartar, A.6
  • 53
  • 54
    • 0032029245 scopus 로고    scopus 로고
    • Expression and function of surface proteins in Trypanosoma brucei
    • Pays E., Nolan D.P. Expression and function of surface proteins in Trypanosoma brucei. Mol. Biochem. Parasitol. 91:1998;3-36.
    • (1998) Mol. Biochem. Parasitol. , vol.91 , pp. 3-36
    • Pays, E.1    Nolan, D.P.2
  • 55
    • 0039830077 scopus 로고    scopus 로고
    • Access to essential drugs in poor countries: A lost battle?
    • Pecoul B., Chirac P., Trouiller P., Pinel J. Access to essential drugs in poor countries: a lost battle? J. Am. Med. Assoc. 281:1999;361-367.
    • (1999) J. Am. Med. Assoc. , vol.281 , pp. 361-367
    • Pecoul, B.1    Chirac, P.2    Trouiller, P.3    Pinel, J.4
  • 56
    • 0031305838 scopus 로고    scopus 로고
    • Efficient process technologies for the preparation of oligonucleotides
    • Pieken W. Efficient process technologies for the preparation of oligonucleotides. Ciba Found. Symp. 209:1997;218-222.
    • (1997) Ciba Found. Symp. , vol.209 , pp. 218-222
    • Pieken, W.1
  • 57
    • 0026337408 scopus 로고
    • Kinetic characterization of ribonuclease-resistant 2′-modified hammerhead ribozymes
    • Pieken W.A., Olsen D.B., Benseler F., Aurup H., Eckstein F. Kinetic characterization of ribonuclease-resistant 2′-modified hammerhead ribozymes. Science. 253:1991;314-317.
    • (1991) Science , vol.253 , pp. 314-317
    • Pieken, W.A.1    Olsen, D.B.2    Benseler, F.3    Aurup, H.4    Eckstein, F.5
  • 58
    • 0031840168 scopus 로고    scopus 로고
    • Dilemmas in drug development for tropical diseases. Experiences with praziquantel
    • Reich M.R., Govindaraj R. Dilemmas in drug development for tropical diseases. Experiences with praziquantel. Health Policy. 44:1998;1-18.
    • (1998) Health Policy , vol.44 , pp. 1-18
    • Reich, M.R.1    Govindaraj, R.2
  • 59
    • 0020069339 scopus 로고
    • Point mutations during generation of expression-linked extra copy of trypanosome surface glycoprotein gene
    • Rice-Ficht A.C., Chen K.K., Donelson J.E. Point mutations during generation of expression-linked extra copy of trypanosome surface glycoprotein gene. Nature. 298:1982;676-679.
    • (1982) Nature , vol.298 , pp. 676-679
    • Rice-Ficht, A.C.1    Chen, K.K.2    Donelson, J.E.3
  • 60
    • 0032493654 scopus 로고    scopus 로고
    • 2′-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain
    • Ruckman J., Green L.S., Beeson J., Waugh S., Gillette W.L., Henninger D.D., Claesson-Welsh L., Janjic N. 2′-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain. J. Biol. Chem. 273:1998;20556-20567.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20556-20567
    • Ruckman, J.1    Green, L.S.2    Beeson, J.3    Waugh, S.4    Gillette, W.L.5    Henninger, D.D.6    Claesson-Welsh, L.7    Janjic, N.8
  • 61
    • 0031890605 scopus 로고    scopus 로고
    • Changing the end: Antigenic variation orchestrated at the telomeres of African trypanosomes
    • Rudenko G., Cross M., Borst P. Changing the end: antigenic variation orchestrated at the telomeres of African trypanosomes. Trends Microbiol. 6:1998;113-116.
    • (1998) Trends Microbiol. , vol.6 , pp. 113-116
    • Rudenko, G.1    Cross, M.2    Borst, P.3
  • 62
    • 0037062920 scopus 로고    scopus 로고
    • Emerging clinical applications of RNA
    • Sullenger B.A., Gilboa E. Emerging clinical applications of RNA. Nature. 418:2002;252-258.
    • (2002) Nature , vol.418 , pp. 252-258
    • Sullenger, B.A.1    Gilboa, E.2
  • 63
    • 0015827948 scopus 로고
    • Effects of the IgG and IgM Immunoglobulins in Trypanosoma gambiense infections in mice
    • Takayanagi T., Enriquez G.L. Effects of the IgG and IgM Immunoglobulins in Trypanosoma gambiense infections in mice. J. Parasitol. 59:1973;644-647.
    • (1973) J. Parasitol. , vol.59 , pp. 644-647
    • Takayanagi, T.1    Enriquez, G.L.2
  • 64
    • 0019751847 scopus 로고
    • Absence of a surface coat from metacyclic Trypanosoma vivax: Possible implications for vaccination against vivax trypanosomiasis
    • Tetley L., Vickerman K., Moloo S.K. Absence of a surface coat from metacyclic Trypanosoma vivax: possible implications for vaccination against vivax trypanosomiasis. Trans. R. Soc. Trop. Med. Hyg. 75:1981;409-414.
    • (1981) Trans. R. Soc. Trop. Med. Hyg. , vol.75 , pp. 409-414
    • Tetley, L.1    Vickerman, K.2    Moloo, S.K.3
  • 65
    • 0035803653 scopus 로고    scopus 로고
    • Responsive hydrophobically associating polymers: A review of structure and properties
    • Tonge S.R., Tighe B.J. Responsive hydrophobically associating polymers: a review of structure and properties. Adv. Drug. Deliv. Rev. 53:2001;109-122.
    • (2001) Adv. Drug. Deliv. Rev. , vol.53 , pp. 109-122
    • Tonge, S.R.1    Tighe, B.J.2
  • 67
    • 0025194307 scopus 로고
    • Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
    • Tuerk C., Gold L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science. 249:1990;505-510.
    • (1990) Science , vol.249 , pp. 505-510
    • Tuerk, C.1    Gold, L.2
  • 68
    • 0035289810 scopus 로고    scopus 로고
    • RNA and DNA aptamers as potential tools to prevent cell adhesion in disease
    • Ulrich H., Alves M.J., Colli W. RNA and DNA aptamers as potential tools to prevent cell adhesion in disease. Braz. J. Med. Biol. Res. 34:2001;295-300.
    • (2001) Braz. J. Med. Biol. Res. , vol.34 , pp. 295-300
    • Ulrich, H.1    Alves, M.J.2    Colli, W.3
  • 69
    • 0037036390 scopus 로고    scopus 로고
    • In vitro selection of RNA aptamers that bind to cell adhesion receptors of Trypanosoma cruzi and inhibit cell invasion
    • Ulrich H., Magdesian M.H., Alves M.J.M., Colli W. In vitro selection of RNA aptamers that bind to cell adhesion receptors of Trypanosoma cruzi and inhibit cell invasion. J. Biol. Chem. 277:2002;20756-20762.
    • (2002) J. Biol. Chem. , vol.277 , pp. 20756-20762
    • Ulrich, H.1    Magdesian, M.H.2    Alves, M.J.M.3    Colli, W.4
  • 70
    • 0031106406 scopus 로고    scopus 로고
    • The primary structure of Trypanosoma (Nannomonas) congolense variant surface glycoproteins
    • Urakawa T., Eshita Y., Majiwa P.A. The primary structure of Trypanosoma (Nannomonas) congolense variant surface glycoproteins. Exp. Parasitol. 85:1997;215-224.
    • (1997) Exp. Parasitol. , vol.85 , pp. 215-224
    • Urakawa, T.1    Eshita, Y.2    Majiwa, P.A.3
  • 72
    • 0027717964 scopus 로고
    • Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins
    • Willis M.C., Hicke B.J., Uhlenbeck O.C., Cech T.R., Koch T.H. Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins. Science. 262:1993;1255-1257.
    • (1993) Science , vol.262 , pp. 1255-1257
    • Willis, M.C.1    Hicke, B.J.2    Uhlenbeck, O.C.3    Cech, T.R.4    Koch, T.H.5
  • 73
    • 0032853242 scopus 로고    scopus 로고
    • In vitro selection of functional nucleic acids
    • Wilson D.S., Szostak J.W. In vitro selection of functional nucleic acids. Annu. Rev. Biochem. 68:1999;611-647.
    • (1999) Annu. Rev. Biochem. , vol.68 , pp. 611-647
    • Wilson, D.S.1    Szostak, J.W.2


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