Effect of Serotonin-related gene polymorphisms on pathogenesis and treatment response in korean schizophrenic patients

Behavior Genetics

Volumn 41, Issue 5, 2011, Pages 709-715

  Kim, Yong Ku ^a,b   Yoon, Ho Kyoung ^a  

^a Korea University College of Medicine   (South Korea)

^b Korea University   (South Korea)

Author keywords

Korean; Polymorphism; Schizophrenia; Serotonin

Indexed keywords

GENOMIC DNA; SEROTONIN;

ADULT; ARTICLE; BRIEF PSYCHIATRIC RATING SCALE; CALGARY DEPRESSION SCALE FOR SCHIZOPHRENIA; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC REGULATION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HTR1A GENE; HTR2A GENE; HUMAN; HUMAN CELL; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; NEGATIVE SYNDROME; POSITIVE AND NEGATIVE SYNDROME SCALE; PSYCHOLOGICAL RATING SCALE; SCHIZOPHRENIA; SEROTONINERGIC SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; SOUTH KOREA; THP1 GENE; THP2 GENE; TREATMENT RESPONSE;

ADULT; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; FEMALE; GENOTYPE; HUMANS; KOREA; MALE; MENTAL DISORDERS; MODELS, GENETIC; MODELS, STATISTICAL; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, SEROTONIN, 5-HT1A; SCHIZOPHRENIA; SEROTONIN;

EID: 80054847329     PISSN: 00018244     EISSN: 15733297     Source Type: Journal    
DOI: 10.1007/s10519-011-9460-7     Document Type: Article

References (56)

1. Abdolmaleky HM, Faraone SV, Glatt SJ, Tsuang MT (2004) Metaanalysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. Schizophr Res 67(1):53-62 (Pubitemid 38117091)
2. Addington D, Addington J, Schissel B (1990) A depression rating scale for schizophrenics. Schizophr Res 3(4):247-251 (Pubitemid 20228720)
3. Anttila S, Kampman O, Illi A, Rontu R, Lehtimäki T, Leinonen E (2007) Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: A serotonergic approach. BMC Psychiatry 7:22
4. APA (1994) Diagnostic and statistical manual of mental disorders. In. American Psychiatric Press, Washington DC, p 886
5. Carlsson A (1978) Antipsychotic drugs, neurotransmitters, and schizophrenia. Am J Psychiatry 135(2):165-173
6. Chee IS, Lee SW, Kim JL, Wang SK, Shin YO, Shin SC, Lee YH, Hwang HM, Lim MR (2001) 5-HT2A receptor gene promoter polymorphism-1438A/G and bipolar disorder. Psychiatr Genet 11(3):111-114 (Pubitemid 32980609)
7. Chen RY, Sham P, Chen EY, Li T, Cheung EF, Hui TC, Kwok CL, Lieh-Mak F, Zhao JH, Collier D, Murray R (2001) No association between T102C polymorphism of serotonin-2A receptor gene and clinical phenotypes of Chinese schizophrenic patients. Psychiatry Res 105(3):175-185 (Pubitemid 34117645)
8. Chotai J, Serretti A, Lorenzi C (2005) Interaction between the tryptophan hydroxylase gene and the serotonin transporter gene in schizophrenia but not in bipolar or unipolar affective disorders. Neuropsychobiology 51(1):3-9 (Pubitemid 40867984)
9. De Luca V, Likhodi O, Van Tol HHM, Kennedy J, Wong AHC (2005) Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophrenia. Psychopharmacology (Berl) 183(3):378-382 (Pubitemid 41660424)
10. Fan JB, Sklar P (2005) Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia. Mol Psychiatry 10(10):928-938 (Pubitemid 41486485)
11. First M, Spitzer RL, Gibbon M, William JB (1998a) Structured clinical interview for DSM-IVAxis I disorders, patient edition (SCID-I/P, version 2.0). Biometrics Research Department, New York State Psychiatric Institute. American Psychiatric Publishing, Inc
12. First M, Spitzer RL, Gibbon M, William JB (1998b) Structured clinical interview for DSM-IVAxis I disorders, non-patient edition (SCID-I/NP, version 2.0). Biometrics Research Department, New York State Psychiatric Institute. American Psychiatric Publishing, Inc
13. Gu B, Wang L, Zhang A-P, Ma G, Zhao X-Z, Li H-F, Feng G-Y, He L, Xing Q-H (2008) Association between a polymorphism of the HTR3A gene and therapeutic response to risperidone treatment in drug-naive Chinese schizophrenia patients. Pharmacogenet Genomics 18(8):721-727
14. Higashi S, Ohnuma T, Shibata N, Higashi M, Matsubara Y, Arai H (2007) No genetic association between tryptophan hydroxylase 2 gene polymorphisms and Japanese schizophrenia. Psychiatr Genet 17(2):123 (Pubitemid 46586686)
15. Hong CJ, Tsai SJ, Wang YC (2001) Association between tryptophan hydroxylase gene polymorphism (A218C) and schizophrenic disorders. Schizophr Res 49(1-2):59-63
16. Hong CJ, Chen TJ, Yu YW, Tsai SJ (2006) Response to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder. Pharmacogenomics J 6(1):27-33 (Pubitemid 43118308)
17. Hoyer D, Pazos A, Probst A, Palacios JM (1986) Serotonin receptors in the human brain. II. Characterization and autoradiographic localization of 5-HT1C and 5-HT2 recognition sites. Brain Res 376(1):97-107 (Pubitemid 16046020)
18. Ichikawa J, Meltzer HY (1999) R(+)-8-OH-DPAT, a serotonin(1A) receptor agonist, potentiated S(-)-sulpiride-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum. J Pharmacol Exp Ther 291(3):1227-1232
19. Jakab RL, Goldman-Rakic PS (1998) 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites. Proc Natl Acad Sci USA 95(2):735-740
20. Kay SR, Opler LA, Lindenmayer JP (1989) The positive and negative syndrome scale (PANSS): Rationale and standardisation. Br J Psychiatry 155(Suppl 7):59-67
21. Kendler KS, Diehl SR (1993) The genetics of schizophrenia: A current, genetic-epidemiologic perspective. Schizophr Bull 19(2):261-285 (Pubitemid 23183148)
22. Kirov G, Zaharieva I, Georgieva L, Moskvina V, Nikolov I, Cichon S, Hillmer A, Toncheva D, Owen MJ, O'Donovan MC (2009) A genome-wide association study in 574 schizophrenia trios using DNA pooling. Mol Psychiatry 14(8):796-803
23. Lane H-Y, Chang Y-C, Chiu C-C, Chen M-L, Hsieh M-H, Chang W-H (2002) Association of risperidone treatment response with a polymorphism in the 5-HT(2A) receptor gene. Am J Psychiatry 159(9):1593-1595 (Pubitemid 35006743)
24. Lewis DA, Lieberman JA (2000) Catching up on schizophrenia: Natural history and neurobiology. Neuron 28(2):325-334
25. Li D, He L (2006) Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia. Hum Genet 120(1):22-30
26. Lidov HG, Molliver ME (1982) An immunohistochemical study of serotonin neuron development in the rat: Ascending pathways and terminal fields. Brain Res Bull 8(4):389-430 (Pubitemid 12025085)
27. Lieberman JA (1993) Understanding the mechanism of action of atypical antipsychotic drugs. A review of compounds in use and development. Br J Psychiatry 163(Suppl 22):7-18 (Pubitemid 23355884)
28. Liégeois J-F, Ichikawa J, Meltzer HY (2002) 5-HT(2A) receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner. Brain Res 947(2):157-165
29. Lin CH, Tsai SJ, Yu YW, Song HL, Tu PC, Sim CB, Hsu CP, Yang KH, Hong CJ (1999) No evidence for association of serotonin-2A receptor variant (102T/C) with schizophrenia or clozapine response in a Chinese population. Neuroreport 10(1):57-60 (Pubitemid 29090478)
30. Lin YM, Chao SC, Chen TM, Lai TJ, Chen JS, Sun HS (2007) Association of functional polymorphisms of the human tryptophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese. Arch Gen Psychiatry 64(9):1015-1024 (Pubitemid 47360846)
31. Lopez VA, Detera-Wadleigh S, Cardona I, Kassem L, McMahon FJ (2007) Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts. Biol Psychiatry 61(2):181-186 (Pubitemid 46091659)
32. McGuffin P, Owen MJ, Farmer AE (1995) Genetic basis of schizophrenia. Lancet 346(8976):678-682
33. Meltzer HY, Matsubara S, Lee JC (1989) Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values. J Pharmacol Exp Ther 251(1): 238-246
34. Moskvina V, Craddock N, Holmans P, Nikolov I, Pahwa JS, Green E, Owen MJ, O'Donovan MC (2009) Gene-wide analyses of genome-wide association data sets: Evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. Mol Psychiatry 14(3):252-260
35. Mössner R, Freitag CM, Gutknecht L, Reif A, Tauber R, Franke P, Fritze J, Wagner G, Peikert G, Wenda B, Sand P, Rietschel M, Garritsen H, Jacob C, Lesch KP, Deckert J (2006) The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder. J Psychopharmacol (Oxf) 20(4):547-552 (Pubitemid 43875184)
36. Mössner R, Schuhmacher A, Kühn K-U, Cvetanovska G, Rujescu D, Zill P, Quednow BB, Rietschel M, Wölwer W, Gaebel W, Wagner M, Maier W (2009) Functional serotonin 1A receptor variant influences treatment response to atypical antipsychotics in schizophrenia. Pharmacogenet Genomics 19(1):91-94
37. Nielsen DA, Jenkins GL, Stefanisko KM, Jefferson KK, Goldman D (1997) Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7. Brain Res Mol Brain Res 45(1):145-148 (Pubitemid 27182236)
38. Nocjar C, Roth BL, Pehek EA (2002) Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience 111(1):163-176 (Pubitemid 34310459)
39. Ohara K, Nagai M, Tani K, Tsukamoto T (1999) Schizophrenia and the serotonin-2A receptor promoter polymorphism. Psychiatry Res 85(2):221-224 (Pubitemid 29136762)
40. Pae C-U, Artioli P, Serretti A, Kim T-S, Kim J-J, Lee C-U, Lee S-J, Lee C, Paik I-H (2005) No evidence for interaction between 5-HT2A receptor and serotonin transporter genes in schizophrenia. Neurosci Res 52(2):195-199 (Pubitemid 40704602)
41. Paik I, Toh K, Kim J, Lee C (2000) TPH gene may be associated with suicidal behavior, but not with schizophrenia in the Korean population. Hum Hered 50(6):365-369 (Pubitemid 30481332)
42. Patel PD, Pontrello C, Burke S (2004) Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland. Biol Psychiatry 55(4):428-433 (Pubitemid 38199994)
43. Peñas-Lledó EM, Dorado P, Cáceres MC, de la Rubia A, Llerena A (2007) Association between T102C and A-1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: Relevance for treatment with antipsychotic drugs. Clin Chem Lab Med 45(7):835-838 (Pubitemid 47041902)
44. Reynolds GP, Arranz B, Templeman LA, Fertuzinhos S, San L (2006) Effect of 5-HT1A receptor gene polymorphism on negative and depressive symptom response to antipsychotic treatment of drug-naive psychotic patients. Am J Psychiatry 163(10):1826-1829 (Pubitemid 44522494)
45. Sáiz PA, García-Portilla MP, Arango C, Morales B, Alvarez V, Coto E, Fernández JM, Bascarán MT, Bousoño M, Bobes J (2007) Association study of serotonin 2A receptor (5-HT2A) and serotonin transporter (5-HTT) gene polymorphisms with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 31(3): 741-745 (Pubitemid 46467056)
46. Sekizawa T, Iwata Y, Nakamura K, Matsumoto H, Suzuki A, Suzuki K, Sekine Y, Takei N, Minabe Y, Mori N (2004) Childhoodonset schizophrenia and tryptophan hydroxylase gene polymorphism. Am J Med Genet 128B(1):24-26 (Pubitemid 38849912)
47. Serretti A, Lilli R, Lorenzi C, Lattuada E, Cusin C, Smeraldi E (1999) Lack of association between tryptophan hydroxylase gene and psychotic symptomatology in schizophrenia. Schizophr Res 40(2):171-172 (Pubitemid 29494240)
48. Shifman S, Johannesson M, Bronstein M, Chen S, Collier D, Craddock N, Kendler K, Li T, O'Donovan M, O'Neill FA, Owen M, Walsh D, Weinberger D, Sun C, Flint J, Darvasi A (2008) Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genet 4(2):e28-e28
49. Sodhi MSK, Sanders-Bush E (2004) Serotonin and brain development. Int Rev Neurobiol 59:111-174 (Pubitemid 39752414)
50. Wang L, Yu L, He G, Zhang J, Zhang A-P, Du J, Tang R-Q, Zhao X-Z, Ma J, Xuan J-K, Xiao Y, Gu N-F, Feng G-Y, Xu M-Q, Xing Q-H, He L (2007) Response of risperidone treatment may be associated with polymorphisms of HTT gene in Chinese schizophrenia patients. Neurosci Lett 414(1):1-4 (Pubitemid 46241633)
51. Werkman TR, Glennon JC, Wadman WJ, McCreary AC (2006) Dopamine receptor pharmacology: Interactions with serotonin receptors and significance for the aetiology and treatment of schizophrenia. CNS Neurol Disord Drug Targets 5(1):3-23 (Pubitemid 43796625)
52. Williams J, McGuffin P, Nöthen M, Owen MJ (1997) Meta-analysis of association between the 5-HT2a receptor T102C polymorphism and schizophrenia. EMASS Collaborative Group. European multicentre association study of Schizophrenia. Lancet 349(9060):1221 (Pubitemid 27190050)
53. Willins DL, Deutch AY, Roth BL (1997) Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex. Synapse 27(1):79-82 (Pubitemid 27327604)
54. Woolley DW, Shaw E (1954) A biochemical and pharmacological suggestion about certain mental disorders. Proc Natl Acad Sci USA 40(4):228-231
55. Zaboli G, Jönsson EG, Gizatullin R, Asberg M, Leopardi R (2006) Tryptophan hydroxylase-1 gene variants associated with schizophrenia. Biol Psychiatry 60(6):563-569 (Pubitemid 44402374)
56. Zill P, Büttner A, Eisenmenger W, Bondy B, Ackenheil M (2004) Regional mRNA expression of a second tryptophan hydroxylase isoform in postmortem tissue samples of two human brains. Eur Neuropsychopharmacol 14(4):282-284 (Pubitemid 38649084)