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Volumn 45, Issue 7, 2007, Pages 835-838

Association between T102C and A-1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: Relevance for treatment with antipsychotic drugs

Author keywords

A 1438G polymorphism; Risperidone; Schizophrenia; Seretonin 2A receptor; T102C polymorphism

Indexed keywords

HALOPERIDOL; NEUROLEPTIC AGENT; RISPERIDONE; SEROTONIN 2A RECEPTOR; THIORIDAZINE;

EID: 34447288445     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2007.181     Document Type: Article
Times cited : (27)

References (31)
  • 1
    • 0001792366 scopus 로고
    • The role of serotonin in schizophrenia
    • Bloom FE, Kupfer DJ, editors, New York, USA: Raven Press
    • Roth BL, Meltzer HY. The role of serotonin in schizophrenia. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology: the fourth generation of progress. New York, USA: Raven Press, 1995:1215-28.
    • (1995) Psychopharmacology: The fourth generation of progress , pp. 1215-1228
    • Roth, B.L.1    Meltzer, H.Y.2
  • 2
    • 0037374767 scopus 로고    scopus 로고
    • The cortical serotonin 2A receptor and the pathology of schizophrenia: A likely accomplice
    • Dean B. The cortical serotonin 2A receptor and the pathology of schizophrenia: a likely accomplice. J Neurochem 2003;85:1-13.
    • (2003) J Neurochem , vol.85 , pp. 1-13
    • Dean, B.1
  • 3
    • 30144436945 scopus 로고    scopus 로고
    • Association study of serotonin 2A receptor (5-HT2A) gene with schizophrenia and suicidal behavior using systematic meta-analysis
    • Li D, Duan Y, He L. Association study of serotonin 2A receptor (5-HT2A) gene with schizophrenia and suicidal behavior using systematic meta-analysis. Biochem Biophys Res Commun 2006;340:1006-15.
    • (2006) Biochem Biophys Res Commun , vol.340 , pp. 1006-1015
    • Li, D.1    Duan, Y.2    He, L.3
  • 4
    • 0025681340 scopus 로고
    • The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14
    • Hsieh CL, Bowcock AM, Farrer LA, Hebert JM, Huang KN, Cavilli-Sforza LL, et al. The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14. Somat Cell Mol Genet 1990;16:567-74.
    • (1990) Somat Cell Mol Genet , vol.16 , pp. 567-574
    • Hsieh, C.L.1    Bowcock, A.M.2    Farrer, L.A.3    Hebert, J.M.4    Huang, K.N.5    Cavilli-Sforza, L.L.6
  • 5
    • 0027300190 scopus 로고
    • An MspI polymorphism in the human serotonin receptor gene (HTR2): Detection by DGGE and RFLP analysis
    • Warren JT, Peacock ML, Rodriguez LC, Fink JK. An MspI polymorphism in the human serotonin receptor gene (HTR2): detection by DGGE and RFLP analysis. Hum Mol Genet 1993;2:338.
    • (1993) Hum Mol Genet , vol.2 , pp. 338
    • Warren, J.T.1    Peacock, M.L.2    Rodriguez, L.C.3    Fink, J.K.4
  • 6
    • 0029873266 scopus 로고    scopus 로고
    • Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. European Multicentre Association Study of Schizophrenia (EMASS) Group
    • Williams J, Spurlock G, McGuffin P, Mallet J, Nothen MM, Gill M, et al. Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. European Multicentre Association Study of Schizophrenia (EMASS) Group. Lancet 1996;347:1294-6.
    • (1996) Lancet , vol.347 , pp. 1294-1296
    • Williams, J.1    Spurlock, G.2    McGuffin, P.3    Mallet, J.4    Nothen, M.M.5    Gill, M.6
  • 7
    • 0040008285 scopus 로고    scopus 로고
    • 5HT 2a receptor T102C polymorphism and schizophrenia
    • Clifford CP, Nunez DJ. 5HT 2a receptor T102C polymorphism and schizophrenia. Lancet 1996;347:1830.
    • (1996) Lancet , vol.347 , pp. 1830
    • Clifford, C.P.1    Nunez, D.J.2
  • 8
    • 0034125860 scopus 로고    scopus 로고
    • The genes for major psychosis: Aberrant sequence or regulation?
    • Petronis A. The genes for major psychosis: aberrant sequence or regulation? Neuropsychopharmacology 2000;23:1-12.
    • (2000) Neuropsychopharmacology , vol.23 , pp. 1-12
    • Petronis, A.1
  • 9
    • 0036178007 scopus 로고    scopus 로고
    • DNA methylation and the regulation of gene transcription
    • Attwood JT, Yung RL, Richardson BC. DNA methylation and the regulation of gene transcription. Cell Mol Life Sci 2002;59:241-57.
    • (2002) Cell Mol Life Sci , vol.59 , pp. 241-257
    • Attwood, J.T.1    Yung, R.L.2    Richardson, B.C.3
  • 10
    • 0035996058 scopus 로고    scopus 로고
    • Effects of phenobarbital on DNA methylation in GC-rich regions of hepatic DNA from mice that exhibit different levels of susceptibility to liver tumorigenesis
    • Watson RE, Goodman JI. Effects of phenobarbital on DNA methylation in GC-rich regions of hepatic DNA from mice that exhibit different levels of susceptibility to liver tumorigenesis. Toxicol Sci 2002;68:51-8.
    • (2002) Toxicol Sci , vol.68 , pp. 51-58
    • Watson, R.E.1    Goodman, J.I.2
  • 11
    • 0031963472 scopus 로고    scopus 로고
    • Evidence for association between polymorphisms in the promoter and coding regions of the 5HT2A receptor gene and response to clozapine
    • Arranz MJ, Munro J, Owen MJ. Evidence for association between polymorphisms in the promoter and coding regions of the 5HT2A receptor gene and response to clozapine. Mol Psychiatry 1998;3:61-6.
    • (1998) Mol Psychiatry , vol.3 , pp. 61-66
    • Arranz, M.J.1    Munro, J.2    Owen, M.J.3
  • 12
    • 4444232862 scopus 로고    scopus 로고
    • The -1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity
    • Parsons MJ, D'Souza UM, Arranz MJ, Kerwin RW, Makoff AJ. The -1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity. Biol Psychiatry 2004;56:406-10.
    • (2004) Biol Psychiatry , vol.56 , pp. 406-410
    • Parsons, M.J.1    D'Souza, U.M.2    Arranz, M.J.3    Kerwin, R.W.4    Makoff, A.J.5
  • 13
    • 0022531874 scopus 로고
    • Serotonin receptors in the human brain. II. Characterization and autoradiographic localization of 5-HT1C and 5-HT2 recognition sites
    • Hoyer D, Pazos A, Probst A, Palacios JM. Serotonin receptors in the human brain. II. Characterization and autoradiographic localization of 5-HT1C and 5-HT2 recognition sites. Brain Res 1986;376:97-107.
    • (1986) Brain Res , vol.376 , pp. 97-107
    • Hoyer, D.1    Pazos, A.2    Probst, A.3    Palacios, J.M.4
  • 14
    • 0025194365 scopus 로고
    • Inhibition of hippocampal CA1 neurons by 5-hydroxytryptamine, derived from the dorsal raphe nucleus and the 5-hydroxytryptamine1A agonist SM-3997
    • Hirose A, Sasa M, Akaike A, Takaori S. Inhibition of hippocampal CA1 neurons by 5-hydroxytryptamine, derived from the dorsal raphe nucleus and the 5-hydroxytryptamine1A agonist SM-3997. Neuropharmacology 1990;29:93-101.
    • (1990) Neuropharmacology , vol.29 , pp. 93-101
    • Hirose, A.1    Sasa, M.2    Akaike, A.3    Takaori, S.4
  • 15
    • 0031594813 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites
    • Jakab RL, Goldman-Rakic PS. 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites. Proc Natl Acad Sci USA 1998;95:735-40.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 735-740
    • Jakab, R.L.1    Goldman-Rakic, P.S.2
  • 16
    • 0030612257 scopus 로고    scopus 로고
    • Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex
    • Willins DL, Deutch AY, Roth BL. Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex. Synapse 1997;27:79-82.
    • (1997) Synapse , vol.27 , pp. 79-82
    • Willins, D.L.1    Deutch, A.Y.2    Roth, B.L.3
  • 17
    • 0037156476 scopus 로고    scopus 로고
    • Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group
    • Nocjar C, Roth BL, Pehek EA. Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience 2002;111:163-76.
    • (2002) Neuroscience , vol.111 , pp. 163-176
    • Nocjar, C.1    Roth, B.L.2    Pehek, E.A.3
  • 18
    • 3242732096 scopus 로고    scopus 로고
    • QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrations
    • LLerena A, Berecz R, Dorado P, de la Rubia A. QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrations. J Psychopharmacol 2004;18:189-93.
    • (2004) J Psychopharmacol , vol.18 , pp. 189-193
    • LLerena, A.1    Berecz, R.2    Dorado, P.3    de la Rubia, A.4
  • 19
    • 0038469903 scopus 로고    scopus 로고
    • Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype
    • Berecz R, de la Rubia A, Dorado P, Fernandez-Salguero P, Dahl ML, Llerena A. Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype. Eur J Clin Pharmacol 2003;59:45-50.
    • (2003) Eur J Clin Pharmacol , vol.59 , pp. 45-50
    • Berecz, R.1    de la Rubia, A.2    Dorado, P.3    Fernandez-Salguero, P.4    Dahl, M.L.5    Llerena, A.6
  • 20
    • 2442438560 scopus 로고    scopus 로고
    • Relationship between haloperidol plasma concentration, debrisoquine metabolic ratio, CYP2D6 and CYP2C9 genotypes in psychiatric patients
    • LLerena A, de la Rubia A, Berecz R, Dorado P. Relationship between haloperidol plasma concentration, debrisoquine metabolic ratio, CYP2D6 and CYP2C9 genotypes in psychiatric patients. Pharmacopsychiatry 2004;37:69-73.
    • (2004) Pharmacopsychiatry , vol.37 , pp. 69-73
    • LLerena, A.1    de la Rubia, A.2    Berecz, R.3    Dorado, P.4
  • 21
    • 0842265864 scopus 로고    scopus 로고
    • The relationship between the response to risperidone treatment and 5-HT2A receptor gene (T102C and 1438G/A) polymorphism in schizophrenia
    • Herken H, Erdal ME, Esgi K, Virit O, Aynacioglu AS. The relationship between the response to risperidone treatment and 5-HT2A receptor gene (T102C and 1438G/A) polymorphism in schizophrenia. Bull Clin Psychopharmacol 2003;13:161-6.
    • (2003) Bull Clin Psychopharmacol , vol.13 , pp. 161-166
    • Herken, H.1    Erdal, M.E.2    Esgi, K.3    Virit, O.4    Aynacioglu, A.S.5
  • 22
    • 1642483062 scopus 로고    scopus 로고
    • Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia
    • Abdolmaleky HM, Faraone SV, Glatt SJ, Tsuang MT. Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. Schizophr Res 2004;67:53-62.
    • (2004) Schizophr Res , vol.67 , pp. 53-62
    • Abdolmaleky, H.M.1    Faraone, S.V.2    Glatt, S.J.3    Tsuang, M.T.4
  • 23
    • 0022930993 scopus 로고
    • Decreased serotonin S2 and increased dopamine D2 receptors in chronic schizophrenics
    • Mita T, Hanada S, Nishino N, Kuno T, Nakai H, Yamadori T, et al. Decreased serotonin S2 and increased dopamine D2 receptors in chronic schizophrenics. Biol Psychiatry 1986;21:1407-14.
    • (1986) Biol Psychiatry , vol.21 , pp. 1407-1414
    • Mita, T.1    Hanada, S.2    Nishino, N.3    Kuno, T.4    Nakai, H.5    Yamadori, T.6
  • 24
    • 0025921604 scopus 로고
    • Serotonin 2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients
    • Arora RC, Meltzer HY. Serotonin 2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients. J Neural Transm 1991;85:19-29.
    • (1991) J Neural Transm , vol.85 , pp. 19-29
    • Arora, R.C.1    Meltzer, H.Y.2
  • 26
    • 0030273870 scopus 로고    scopus 로고
    • 5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia
    • Burnet PW, Eastwood SL, Harrison PJ. 5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia. Neuropsychopharmacology 1996;15:442-55.
    • (1996) Neuropsychopharmacology , vol.15 , pp. 442-455
    • Burnet, P.W.1    Eastwood, S.L.2    Harrison, P.J.3
  • 27
    • 0032868798 scopus 로고    scopus 로고
    • The role of serotonin in antipsychotic drug action
    • Meltzer HY. The role of serotonin in antipsychotic drug action. Neuropsychopharmacology 1999;21:106S-115S.
    • (1999) Neuropsychopharmacology , vol.21
    • Meltzer, H.Y.1
  • 28
    • 0035981177 scopus 로고    scopus 로고
    • No association between T102C polymorphism of serotonin-2A receptor gene and clinical phenotypes of Chinese schizophrenic patients
    • Chen RY, Sham P, Chen EY, Li T, Cheung EF, Cheung HK, et al. No association between T102C polymorphism of serotonin-2A receptor gene and clinical phenotypes of Chinese schizophrenic patients. Psychiatry Res 2001;105:175-85.
    • (2001) Psychiatry Res , vol.105 , pp. 175-185
    • Chen, R.Y.1    Sham, P.2    Chen, E.Y.3    Li, T.4    Cheung, E.F.5    Cheung, H.K.6
  • 29
    • 0033090841 scopus 로고    scopus 로고
    • T102C polymorphism in the 5HT2A gene and schizophrenia: Relation to phenotype and drug response variability
    • Joober R, Benkelfat C, Brisebois K, Toulouse A, Turecki G, Lal S, et al. T102C polymorphism in the 5HT2A gene and schizophrenia: relation to phenotype and drug response variability. J Psychiatry Neurosci 1999;24:141-6.
    • (1999) J Psychiatry Neurosci , vol.24 , pp. 141-146
    • Joober, R.1    Benkelfat, C.2    Brisebois, K.3    Toulouse, A.4    Turecki, G.5    Lal, S.6
  • 30
    • 0036713871 scopus 로고    scopus 로고
    • Association of risperidone treatment response with a polymorphism in the 5-HT(2A) receptor gene
    • Lane HY, Chang YC, Chiu CC, Chen ML, Hsieh MH, Chang WH. Association of risperidone treatment response with a polymorphism in the 5-HT(2A) receptor gene. Am J Psychiatry 2002;159:1593-5.
    • (2002) Am J Psychiatry , vol.159 , pp. 1593-1595
    • Lane, H.Y.1    Chang, Y.C.2    Chiu, C.C.3    Chen, M.L.4    Hsieh, M.H.5    Chang, W.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.