Response of risperidone treatment may be associated with polymorphisms of HTT gene in Chinese schizophrenia patients

Neuroscience Letters

Volumn 414, Issue 1, 2007, Pages 1-4

  Wang, Lei ^a,b   Yu, Lan ^b   He, Guang ^a,b   Zhang, Jing ^a,b   Zhang, Ai Ping ^a,b   Du, Jing ^a,b   Tang, Rui Qi ^a,b   Zhao, Xin Zhi ^a,b   Ma, Jie ^a,b   Xuan, Jie Kun ^a,b   Xiao, Yue ^a,b   Gu, Niu Fan ^c   Feng, Guo Ying ^c   Xu, Ming Qing ^d   Xing, Qing He ^a,b   He, Lin ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^c SHANGHAI MENTAL HEALTH CENTER   (China)

^d NONE

Author keywords

5 HTT; Polymorphisms; Risperidone treatment response; Schizophrenia

Indexed keywords

RISPERIDONE; SEROTONIN TRANSPORTER;

ADULT; ALLELE; ARTICLE; BRIEF PSYCHIATRIC RATING SCALE; CHINESE; CLINICAL FEATURE; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DRUG EFFICACY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC POLYMORPHISM; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL ASSESSMENT; MONOTHERAPY; PREDICTION; PRIORITY JOURNAL; SCHIZOPHRENIA; SEROTONIN UPTAKE; SEROTONINERGIC NERVE CELL; TANDEM REPEAT; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADULT; ANTIPSYCHOTIC AGENTS; BRAIN; BRAIN CHEMISTRY; CHINA; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HAPLOTYPES; HUMANS; MALE; POLYMORPHISM, GENETIC; RISPERIDONE; SCHIZOPHRENIA; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 33846923067     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.09.014     Document Type: Article

References (31)

1. Arranz M.J., Munro J., Birkett J., Bolonna A., Mancama D., Sodhi M., Lesch K.P., Meyer J.F., Sham P., Collier D.A., Murray R.M., and Kerwin R.W. Pharmacogenetic prediction of clozapine response. Lancet 355 (2000) 1615-1616
2. Bellivier F., Leroux M., Henry C., Rayah F., Rouillon F., Laplanche J.L., and Leboyer M. Serotonin transporter gene polymorphism influences age at onset in patients with bipolar affective disorder. Neurosci. Lett. 334 (2002) 17-20
3. Bengel D., Murphy D.L., Andrews A.M., Wichems C.H., Feltner D., Heils A., Mossner R., Westphal H., and Lesch K.P. Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol. Pharmacol. 53 (1998) 649-655
4. Collier D.A., Stober G., Li T., Heils A., Catalano M., Di Bella D., Arranz M.J., Murray R.M., Vallada H.P., Bengle D., Muller C.R., Roberts G.W., Smeraldi E., Kirov G., Sham P., and Lesch K.P. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol. Psychiatry 1 (1996) 453-460
5. Di Bella D., Erzegovesi S., Cavallini M.C., and Bellodi L. Obsessive-compulsive disorder, 5-HTTLPR polymorphism and treatment response. Pharmacogenomics J. 2 (2002) 176-181
6. M. Flaum, X. Amador, J. Gorman, H.s. Bracha, W. Edell, T. McGlashan, A. Pandurangi, K.S. Kendler, D. Robinson, J. Lieberman, A. Ontiveros, M. Tohen, P. McGorry, G. Tyrrell, S. Arndt, N.C. Andresen, DSM-IV Field Trial for Schizophrenia and Other Psychiatric Association, Washington, DC, 1997, pp. 687-713.
7. Gao B., Guo J., She C., Shu A., Yang M., Tan Z., Yang X., Guo S., Feng G., and He L. Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1. Nat. Genet. 28 (2002) 386-388
8. Heinz A., Ragan P., Jones D.W., Hommer D., Williams W., Knable M.B., Gorey J.G., Doty L., Geyer C., Lee K.S., Coppola R., Weinberger D.R., and Linnoila M. Reduced central serotonin transporters in alcoholism. Am. J. Psychiatry 155 (1998) 1544-1549
9. Kane J.M. Treatment of schizophrenia. Schizophr. Bull. 13 (1987) 133-156
10. Kim D.K., Lim S.W., Lee S., Sohn S.E., Kim S., Hahn C.G., and Carroll B.J. Serotonin transporter gene polymorphism and antidepressant response. Neuroreport 11 (2000) 215-219
11. Lane H.Y., Chang Y.C., Chiu C.C., Chen M.L., Hsieh M.H., and Chang W.H. Association of risperidone treatment response with a polymorphism in the 5-HT(2A) receptor gene. Am. J. Psychiatry 159 (2002) 1593-1595
12. Lane H.Y., Hsu S.K., Liu Y.C., Chang Y.C., Huang C.H., and Chang W.H. Dopamine D3 receptor Ser9Gly polymorphism and risperidone response. J. Clin. Psychopharmacol. 25 (2005) 6-11
13. Lesch K.P. Neuroticism and serotonin: a developmental genetic perspective. In: Plomin R., DeFries J., Craig I., and McGuffin P. (Eds). Behavioral Genetics in the Postgenomic Era (2003), American Psychiatric Press, Washington, DC 389-423
14. Lesch K.P., and Gutknecht L. Pharmacogenetics of the serotonin transporter. Prog. Neuropsychopharmacol. Biol. Psychiatry 29 (2005) 1062-1073
15. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., Benjamin J., Muller C.R., Hamer D.H., and Murphy D.L. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 (1996) 1527-1531
16. Leysen J.E., Janssen P.M., Megens A.A., and Schotte A. Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J. Clin. Psychiatry 55 (1994) 5-12
17. Lieberman J.A., Mailman R.B., Duancan G., Sikich L., Chakos M., Nichols D.E., and Kraus J.E. Serotonergic basis of antipsychotic drug effects in schizophrenia. Biol. Psychiatry 44 (1998) 1099-1117
18. Lucki I. The spectrum of behaviors influenced by serotonin. Biol. Psychiatry 44 (1998) 151-162
19. Mackenzie A., and Quinn J. A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 15251-15255
20. Overall J.E., and Gorham D.R. The brief psychiatric rating scale. Psychol. Rep. 10 (1962) 799-812
21. M.J. Owens, C.A. Ballenger, D.L. Knight, C.B. Nemeroff, Platelet 5-hydroxytryptamine (5-HT) transporter and 5-HT2A receptor binding after chronic hypercorticosteronemia, (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane administration or neurotoxin-induced depletion of central nervous system 5-HT in the rat, J. Pharmacol. Exp. Ther. 278 (3) 1040-1049.
22. Pollock B.G., Ferrell R.E., Mulsant B.H., Mazumdar S., Miller M., Sweet R.A., Davis S., Kirshner M.A., Houck P.R., Stack J.A., Reynold C.F., and Kupfer D.J. Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology 23 (2000) 587-590
23. Reynold G.P., Yao Z., Zhang X., Sun J., and Zhang Z. Pharmacogenetics of treatment in first-episode schizophrenia: D3 and 5-HT2C receptor polymorphisms separately associate with positive and negative symptom response. Eur. Neuropsychopharmacol. 15 (2005) 143-151
24. Sham P.C., and Curtis D. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann. Hum. Genet. 59 (1995) 97-105
25. Smeraldi E., Zanardi R., Benedetti F., Di Bella D., Perez J., and Catalano M. Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol. Psychiatry 3 (1998) 508-511
26. Stanley M., Virgilio J., and Gershon S. Tritiated imipramine binding sites are decreased in the frontal cortex of suicides. Science 216 (1982) 1337-1339
27. Tarazi F.I., Zhang K., and Baldessarini R.J. Long-term effects of olanzapine, risperidone, and quetiapine on serotonin 1A, 2A and 2C receptors in rat forebrain regions. Psychopharmacology (Berl) 161 (2002) 263-270
28. Tsai S.J., Hong C.J., Yu Y.W., Lin C.H., Song H.L., Lai H.C., and Yang K.H. Association study of a functional serotonin transporter gene polymorphism with schizophrenia, psychopathology and clozapine response. Schizophr. Res. 44 (2000) 177-181
29. Veenstra-Vanderweele J., Anderson G.M., and Cook E.H. Pharmacogenetics and the serotonin system: initial studies and future directions. Eur. J. Pharmacol. 410 (2000) 165-181
30. Zalsman G., Frisch A., Lev-Ran S., Martin A., Michaelovsky E., Bensason D., Gothelf D., Nahshoni E., Tyano S., and Weizman A. DRD4 exon III polymorphism and response to risperidone in Israeli adolescents with schizophrenia: a pilot pharmacogenetic study. Eur. Neuropsychopharmacol. 13 (2003) 183-185
31. Zhao J.H., Curtis D., and Sham P.C. Model-free analysis and permutation tests for allelic associations. Hum. Hered. 50 (2000) 133-139