Association between tryptophan hydroxylase gene polymorphism (A218C) and schizophrenic disorders

Schizophrenia Research

Volumn 49, Issue 1-2, 2001, Pages 59-63

  Hong, Chen Jee ^a,b   Tsai, Shih Jen ^a,b   Wang, Ying Chieh ^c  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c YULI VETERANS HOSPITAL   (Taiwan)

Author keywords

Association study; Schizophrenia; Serotonin; Suicide; Tryptophan hydroxylase

Indexed keywords

TRYPTOPHAN HYDROXYLASE;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; RISK FACTOR; SCHIZOPHRENIA; SUICIDAL BEHAVIOR; TAIWAN;

ACUTE DISEASE; ADULT; BRAIN; CHROMOSOME ABERRATIONS; CHROMOSOME DISORDERS; CHROMOSOMES, HUMAN, PAIR 11; FEMALE; GENE FREQUENCY; HOSPITALIZATION; HOSPITALS, PSYCHIATRIC; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; POLYMORPHISM, GENETIC; REFERENCE VALUES; SCHIZOPHRENIA; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

EID: 0035871057     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(00)00039-6     Document Type: Article

References (17)

1. Bellivier F., Leboyer M., Courtet P., Buresi C., Beaufils B., Samolyk D., Allilaire J.F., Feingold J., Mallet J., Malafosse A. Association between the tryptophan hydroxylase gene and manic-depressive. Arch. Gen. Psychiatry. 55:1998;33-37.
2. Craig S.P., Boularand S., Darmon M.C., Mallet J., Craig I.W. Localization of human tryptophan hydroxylase (TPH) to chromosome 11p15.3-p14 by in situ hybridization. Cytogenet. Cell Genet. 56:1991;157-159.
3. Han L., Nielsen D.A., Rosenthal N.E., Jefferson K., Kaye W., Murphy D., Altemus M., Humphries J., Cassano G., Rotondo A., Virkkunen M., Linnoila M., Goldman D. No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism. Biol. Psychiatry. 45:1999;615-619.
4. Hovatta I., Seppala J., Pekkarinen P., Tanskanen A., Lonnqvist J., Peltonen L. Linkage analysis in two schizophrenic families originating from a restricted subpopulation of Finland. Psychiatr. Genet. 4:1994;143-152.
5. Kunugi H., Ishida S., Kato T., Sakai T., Tatsumi M., Hirose T., Nanko S. No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patients. Am. J. Psychiatry. 156:1999;774-776.
6. Macciardi F., Petronis A., Van Tol H.H., Marino C., Cavallini M.C., Smeraldi E., Kennedy J.L. Analysis of the D4 dopamine receptor gene variant in an Italian schizophrenia kindred. Arch. Gen. Psychiatry. 51:1994;288-393.
7. Mann J.J., Malone K.M., Nielsen D.A., Goldman D., Erdos J., Gelernter J. Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients. Am. J. Psychiatry. 154:1997;1451-1453.
8. New A.S., Gelernter J., Yovell Y., Trestman R.L., Nielsen D.A., Silverman J., Mitropoulou V., Siever L.J. Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study. Am. J. Med. Genet. 81:1998;13-17.
9. Nielsen D.A., Goldman D., Virkkunen M., Tokola R., Rawlings R., Linnoila M. Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Arch. Gen. Psychiatry. 51:1994;34-38.
10. Nielsen D.A., Jenkins G.L., Stefanisko K.M., Jefferson K.K., Goldman D. Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7. Mol. Brain Res. 45:1997;145-148.
11. Nielsen D.A., Virkkunen M., Lappalainen J., Eggert M., Brown G.L., Long J.C., Goldman D., Linnoila M. A tryptophan hydroxylase gene marker for suicidality and alcoholism. Arch. Gen. Psychiatry. 55:1998;593-602.
12. Okuyama Y., Ishiguro H., Toru M., Arinami T. A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia. Biochem. Biophys. Res. Commun. 258:1999;292-295.
13. Rotondo A., Schuebel K., Bergen A., Aragon R., Virkkunen M., Linnoila M., Goldman D., Nielsen D.A. Identification of four variants in the tryptophan hydroxylase promoter and association to behavior. Mol. Psychiatry. 4:1999;360-368.
14. Shaikh S., Gill M., Owen M., Asherson P., McGuffin P., Nanko S., Murray R.M., Collier D.A. Failure to find linkage between a functional polymorphism in the dopamine D4 receptor gene and schizophrenia. Am. J. Med. Genet. 54:1994;8-11.
15. Tsai S.-J., Chiu H.-J., Wang Y.-C., Hong C.-J. Association study of sertonin-6 receptor variant (C267T) with schizophrenia and aggressive behavior. Neurosci. Lett. 271:1999;135-137.
16. Virkkunen M., Goldman D., Nielsen D.A., Linnoila M. Low brain serotonin turnover rate (low CSF 5-HIAA) and impulsive violence. J. Psychiatry Neurosci. 20:1995;271-275.
17. Wang G.A., Coon S.L., Kaufman S. Alternative splicing at the 3′-cDNA of human tryptophan hydroxylase. J. Neurochem. 71:1998;1769-1772.