Melatonin prolongs graft survival of pancreas allotransplants in pigs

Journal of Pineal Research

Volumn 51, Issue 4, 2011, Pages 445-453

  García Gil, Francisco A ^a   Albendea, Carlos D ^b   Escartín, Jorge ^a   Lampreave, Fermin ^a   Fuentes Broto, Lorena ^b   Rosellõ Catafau, Joan ^c   Lõpez Pingarrõn, Laura ^a   Reiter, Russel J ^d   Alvarez Alegret, Ramiro ^e   García, Joaquín J ^b  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b UNIVERSITY OF ZARAGOZA   (Spain)

^c INST D INVESTIGACIONS B   (Spain)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^e HOSPITAL UNIVERSITARIO MIGUEL SERVET   (Spain)

Author keywords

ascorbic acid; inter trypsin inhibitor heavy chain 4; ischemia reperfusion; melatonin; oxidative stress; pancreas transplantation

Indexed keywords

ACUTE PHASE PROTEIN; ASCORBIC ACID; MALONALDEHYDE; MELATONIN; PROTEIN; PROTEIN ITIH4; UNCLASSIFIED DRUG; UNIVERSITY OF WISCONSIN SOLUTION;

ACUTE GRAFT REJECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLD ISCHEMIA; CONTROLLED STUDY; FEMALE; GRAFT RECIPIENT; GRAFT SURVIVAL; NONHUMAN; ORGAN DONOR; ORGAN PRESERVATION; OXIDATIVE STRESS; PANCREAS TRANSPLANTATION; POSTOPERATIVE PERIOD; SWINE;

ALPHA-GLOBULINS; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; FEMALE; GRAFT SURVIVAL; MELATONIN; OXIDATIVE STRESS; PANCREAS TRANSPLANTATION; SWINE; TRANSPLANTATION, HOMOLOGOUS;

EID: 80054822940     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2011.00908.x     Document Type: Article

References (71)

1. White SA, Shaw JA, Sutherland DE,. Pancreas transplantation. Lancet 2009; 373: 1808-1817.
2. Gruessner AC, Sutherland DER,. Pancreas transplant outcomes for United States (US) and non-US cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR) as of June 2004. Clin Transpl 2005; 19: 433-455. (Pubitemid 40990653)
3. Wullstein C, Drognitz O, Woeste G, et al., High levels of C-reactive protein after simultaneous pancreas-kidney transplantation predict pancreas graft-related complications and graft survival. Transplantation 2004; 77: 60-64. (Pubitemid 38116873)
4. Witzigmann H, Ludwig S, Armann B, et al., Endothelin-A receptor blockade reduces ischemia/reperfusion injury in pig pancreas transplantation. Ann Surg 2003; 238: 264-274. (Pubitemid 38174502)
5. Drognitz O, Obermaier R, Von Dobschuetz E, et al., Pancreas transplantation and ischemia-reperfusion injury: current considerations. Pancreas 2009; 38: 226-227.
6. Zaouali MA, Ben Abdennebi H, Padrissa-Altés S, et al., Pharmacological strategies against cold ischemia reperfusion injury. Expert Opin Pharmacother 2010; 11: 537-555.
7. Land WG,. The role of postischemic reperfusion injury and other nonantigen-dependent inflammatory pathways in transplantation. Transplantation 2005; 79: 505-514. (Pubitemid 40372243)
8. Casillas-Ramírez A, Ben Mosbah I, Ramalho F, et al., Past and future approaches to ischemia-reperfusion lesion associated with liver transplantation. Life Sci 2006; 79: 1881-1894. (Pubitemid 44488610)
9. Ma A, Qi S, Chen H,. Antioxidant therapy for prevention of inflammation, ischemic reperfusion injuries and allograft rejection. Cardiovasc Hematol Agents Med Chem 2008; 6: 20-43. (Pubitemid 351247874)
10. Tan DX, Chen LD, Poeggeler B, et al., Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocr J 1993; 1: 57-60.
11. Reiter RJ, Maestroni GJM,. Melatonin in relation to the antioxidative defense and immune systems: possible implications for cell and organ transplantation. J Mol Med 1999; 77: 36-39. (Pubitemid 29146179)
12. Hardeland R, Tan DX, Reiter RJ,. Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. J Pineal Res 2009; 47: 109-126.
13. Ates B, Yilmaz I, Geckil H, et al., Protective role of melatonin given either before ischemia or prior to reperfusion on intestinal ischemia-reperfusion damage. J Pineal Res 2004; 37: 149-152. (Pubitemid 39274111)
14. Kurcer Z, Oguz E, Ozbilge H, et al., Melatonin protects from ischemia/reperfusion-induced renal injury in rats: this effect is not mediated by proinflammatory cytokines. J Pineal Res 2007; 43: 172-178. (Pubitemid 47077220)
15. Kim SH, Lee SM,. Cytoprotective effects of melatonin against necrosis and apoptosis induced by ischemia/reperfusion injury in rat liver. J Pineal Res 2008; 44: 165-171.
16. Liang R, Nickkholgh A, Hoffmann K, et al., Melatonin protects from hepatic reperfusion injury through inhibition of IKK and JNK pathways and modification of cell proliferation. J Pineal Res 2009; 46: 8-14.
17. Chen Z, Chua CC, Gao J, et al., Prevention of ischemia/reperfusion- induced cardiac apoptosis and injury by melatonin is independent of glutathione peroxidase 1. J Pineal Res 2009; 46: 235-241.
18. Niki E, Noguchi N, Tsuchihashi H, et al., Interaction among vitamin C, vitamin E and β-carotene. Am J Clin Nutr 1995; 62: 13225-13265.
19. Block G, Jensen CD, Morrow JD, et al., The effect of vitamins C and E on biomarkers of oxidative stress depends on baseline level. Free Radic Biol Med 2008; 45: 377-384.
20. Costa EJX, Lopes RH, Lamy-Freund MT,. Permeability of pure lipid bilayers to melatonin. J Pineal Res 1995; 19: 123-126.
21. Shida CS, Castrucci AML, Lamy-Freund MI,. High melatonin solubility in aqueous medium. J Pineal Res 1994; 16: 198-201.
22. Lee YD, Kim JY, Lee KH, et al., Melatonin attenuates lipopolysaccharide- induced acute lung inflammation in sleep-deprived mice. J Pineal Res 2009; 46: 53-57.
23. Chahbouni M, Escames G, Venegas C, et al., Melatonin treatment normalizes plasma pro-inflammatory cytokines and nitrosative/oxidative stress in patients suffering from Duchenne muscular dystrophy. J Pineal Res 2010; 48: 282-289.
24. Jaworek J, Leja-Szpak A, Bonior J, et al., Protective effect of melatonin and its precursor l-tryptophan on acute pancreatitis induced by caerulein overstimulation or ischemia/reperfusion. J Pineal Res 2003; 34: 40-52. (Pubitemid 36140357)
25. Muñoz-Casares FC, Padillo FJ, Briceño J, et al., Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas. J Pineal Res 2006; 40: 195-203. (Pubitemid 43344655)
26. Vairetti M, Ferrigno A, Bertone R, et al., Exogenous melatonin enhances bile flow and ATP levels after cold storage and reperfusion in rat liver: implications for liver transplantation. J Pineal Res 2005; 38: 223-230. (Pubitemid 41475433)
27. Fildes JE, Yonan N, Keevil BG,. Melatonin-a pleiotropic molecule involved in pathophysiological processes following organ transplantation. Immunology 2009; 127: 443-449.
28. Lima-Rodríguez JR, García-Gil FA, García- García JJ, et al., Effects of premedication with tiletamine/zolazepam/ medetomidine during general anesthesia using sevoflurane/fentanyl in swine undergoing pancreas transplantation. Transplant Proc 2008; 40: 3001-3006.
29. González-Ramõn N, Hoebe K, Alava MA, et al., Pig-MAP/ITIH4 and haptoglobin are interleukin-6-dependent acute-phase plasma proteins in porcine primary cultured hepatocytes. Eur J Biochem 2000; 267: 1878-1885. (Pubitemid 30165543)
30. García-Gil FA, Lampreave F, Fuentes-Broto L, et al., Inter-alpha-trypsin inhibitor heavy chain 4 as a marker of acute rejection in pancreas allotransplantation in pigs. Transplant Proc 2010; 42: 3063-3069.
31. Janero DR,. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med 1990; 9: 515-540. (Pubitemid 120036914)
32. Drachenberg CB, Odorico J, Demetris AJ, et al., Banff schema for grading pancreas allograft rejection: working proposal by a multi-disciplinary international consensus panel. Am J Transplant 2008; 8: 1237-1249. (Pubitemid 351763668)
33. Bradford MM,. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
34. Lampreave F, Gonzalez-Ramon N, Martinez-Ayensa S, et al., Characterization of the acute phase serum protein response in pigs. Electrophoresis 1994; 15: 672-676. (Pubitemid 24181994)
35. Zaouali MA, Reiter RJ, Padrissa-Altés S, et al., Melatonin protects steatotic and nonsteatotic liver grafts against cold ischemia and reperfusion injury. J Pineal Res 2011; 50: 213-221.
36. Kubo S, Yamamoto K, Magata Y, et al., Assessment of pancreatic blood flow with positron emission tomography and oxygen-15 water. Ann Nucl Med 1991; 5: 133-138.
37. Tiedge M, Lortz S, Drinkgern J, et al., Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 1997; 46: 1733-1742. (Pubitemid 27456404)
38. Gao S, Li P, Pan T, et al., Cardioprotective effects of melatonin on recovery of rat donor hearts after 12-hour preservation. J Huazhong Univ Sci Technolog Med Sci 2003; 23: 407-410. (Pubitemid 41559721)
39. Diem P, Abid M, Redmon JB, et al., Systemic venous drainage of pancreas allografts as independent cause of hyperinsulinemia in type I diabetic recipients. Diabetes 1990; 39: 534-540. (Pubitemid 20223777)
40. Garcia-Gil FA, Gonzalvo E, Garcia-Garcia JJ, et al., Lipidic peroxidation on ischemia-reperfusion oxidative injury of the graft preserved in Celsior and University of Wisconsin solutions on a pig pancreas transplantation model. Transplant Proc 2006; 38: 2595-2599. (Pubitemid 44693688)
41. Fridell JA, Mangus RS, Powelson JA,. Histidine-tryptophan-ketoglutarate for pancreas allograft preservation: the Indiana University experience. Am J Transplant 2010; 10: 1284-1289.
42. Lin GJ, Huang SH, Chen YW, et al., Melatonin prolongs islet graft survival in diabetic NOD mice. J Pineal Res 2009; 47: 284-292.
43. Jung FJ, Yang L, Härter L, et al., Melatonin in vivo prolongs cardiac allograft survival in rats. J Pineal Res 2004; 37: 36-41. (Pubitemid 38969018)
44. Mayer H, Schmidt J, Thies J, et al., Characterization and reduction of ischemia/reperfusion injury after experimental pancreas transplantation. J Gastrointest Surg 1999; 3: 162-166.
45. Sapmaz E, Ayar A, Celik H, et al., Effects of melatonin and oxytetracycline in autologous intraperitoneal ovary transplantation in rats. Neuroendocrinol Lett 2003; 24: 350-354. (Pubitemid 37368848)
46. Inci I, Inci D, Dutly A, et al., Melatonin attenuates posttransplant lung ischemia-reperfusion injury. Ann Thorac Surg 2002; 73: 220-225. (Pubitemid 34084566)
47. Li Z, Nickkholgh A, Yi X, et al., Melatonin protects kidney grafts from ischemia/reperfusion injury through inhibition of NF-kB and apoptosis after experimental kidney transplantation. J Pineal Res 2009; 46: 365-372.
48. Rodríguez C, Mayo JC, Sainz RM, et al., Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 2004; 36: 1-9. (Pubitemid 38130283)
49. Bettahi I, Pozo D, Osuna C, et al., Melatonin reduces nitric oxide synthase activity in rat hypothalamus. J Pineal Res 1996; 20: 205-210. (Pubitemid 126733163)
50. García JJ, Reiter RJ, Guerrero JM, et al., Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation. FEBS Lett 1997; 408: 297-300. (Pubitemid 27227019)
51. Acuña-Castroviejo D, Martín M, Macías M, et al., Melatonin, mitochondria, and cellular bioenergetics. J Pineal Res 2001; 30: 65-74. (Pubitemid 32176208)
52. Tan DX, Manchester LC, Reiter RJ, et al., Ischemia/reperfusion-induced arrhythmias in the isolated rat heart: prevention by melatonin. J Pineal Res 1998; 25: 184-191. (Pubitemid 28430599)
53. Hardeland R, Backhaus C, Fadavi A,. Reactions of the NO redox forms NO+, ·NO and HNO (protonated NO) with the melatonin metabolite N1-acetyl-5-methoxykynuramine. J Pineal Res 2007; 43: 382-388. (Pubitemid 47512270)
54. Burns AM, Shelly MP, Walker S, et al., Serum acute phase proteins after orthotopic liver transplantation. Br J Anaesth 1990; 65: 418-420. (Pubitemid 20275630)
55. Izumi S, Hughes RD, Langley PG, et al., Acute phase response after liver transplantation for fulminant hepatic failure and cirrhosis. Transpl Int 1995; 8: 340-345.
56. Hartmann A, Eide TC, Fauchald P, et al., Serum amyloid A protein is a clinically useful indicator of acute renal allograft rejection. Nephrol Dial Transplant 1997; 12: 161-166. (Pubitemid 27046221)
57. González-Ramõn N, Alava MA, Sarsa JA, et al., The major acute phase serum protein in pigs is homologous to human plasma kallikrein sensitive PK-120. FEBS Lett 1995; 371: 227-230.
58. Piñeiro M, Alava MA, González-Ramõn N, et al., ITIH4 serum concentration increases during acute-phase processes in human patients and is up-regulated by interleukin-6 in hepatocarcinoma HepG2 cells. Biochem Biophys Res Commun 1999; 263: 224-229. (Pubitemid 29443667)
59. Daveau M, Jean L, Soury E, et al., Hepatic and extra-hepatic transcription of inter-alpha-inhibitor family genes under normal or acute inflammatory condition in rat. Arch Biochem Biophys 1998; 350: 315-323. (Pubitemid 28368659)
60. Raeburn CD, Sheppard F, Barsness KA, et al., Cytokines for surgeons. Am J Surg 2002; 183: 268-273. (Pubitemid 34273983)
61. Gitto E, Romeo C, Reiter RJ, et al., Melatonin reduces oxidative stress in surgical neonates. J Pediatr Surg 2004; 39: 184-189. (Pubitemid 38146434)
62. Yousaf F, Seet E, Venkatraghavan L, et al., Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials. Anesthesiology 2010; 113: 968-976.
63. Borazan H, Tuncer S, Yalcin N, et al., Effects of preoperative oral melatonin medication on postoperative analgesia sleep quality, and sedation in patients undergoing elective prostatectomy: a randomized clinical trial. J Anesth 2010; 24: 155-160.
64. Tekbas OF, Ogur R, Korkmaz A, et al., Melatonin as an antibiotic: new insights into the actions of this ubiquitous molecule. J Pineal Res 2008; 44: 222-226. (Pubitemid 351255501)
65. Nunes ODAS, Pereira RDES,. Regression of herpes viral infection symptoms using melatonin and SB-73: comparison with Acyclovir. J Pineal Res 2008; 44: 373-378. (Pubitemid 351533521)
66. Escames G, Acuña-Castroviejo D, Lõpez LC, et al., Pharmacological utility of melatonin in the treatment of septic shock: experimental and clinical evidence. J Pharm Pharmacol 2006; 58: 1153-1165. (Pubitemid 44335028)
67. Srinivasan V, Pandi-Perumal SR, Spence DW, et al., Melatonin in septic shock: some recent concepts. J Crit Care 2010; 25: 656.e1-656.e6.
68. Barchas J, Dacosta F, Spector S,. Acute pharmacology of melatonin. Nature 1967; 214: 919-920.
69. Reiter RJ, Tang L, García JJ, et al., Pharmacological actions of melatonin in free radical pathophysiology. Life Sci 1997; 60: 2255-2271.
70. Jahnke G, Marr M, Myers C, et al., Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats. Toxicol Sci 1999; 50: 271-279. (Pubitemid 29407090)
71. Kücükakin B, Lykkesfeldt J, Nielsen HJ, et al., Utility of melatonin to treat surgical stress after major vascular surgery-a safety study. J Pineal Res 2008; 44: 426-431. (Pubitemid 351533527)