Prevention of ischemia/reperfusion-induced cardiac apoptosis and injury by melatonin is independent of glutathione peroxdiase 1

Journal of Pineal Research

Volumn 46, Issue 2, 2009, Pages 235-241

  Chen, Zhongyi ^a   Chua, Chu C ^a   Gao, Jinping ^a   Chua, Kao Wei ^a   Ho, Ye Shih ^b   Hamdy, Ronald C ^a   Chua, Balvin H L ^a  

^a East Tennessee State University   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Free radical scavenger; Glutathione peroxidase; Melatonin; Myocardial reperfusion injury

Indexed keywords

GLUTATHIONE PEROXIDASE 1; LACTATE DEHYDROGENASE; MELATONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DISEASE EXACERBATION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART RATE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; REPERFUSION INJURY;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; GLUTATHIONE PEROXIDASE; MELATONIN; MICE; MICE, KNOCKOUT; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; MYOCYTES, CARDIAC;

EID: 59149096686     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2008.00654.x     Document Type: Article

References (37)

1. Murphy E, Steenbergen C. Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol Rev 2008 88 : 581 609.
2. Das M, Das DK. Molecular mechanism of preconditioning. IUBMB Life 2008 60 : 199 203.
3. Chen Z, Siu B, Ho YS et al. Overexpression of MnSOD protects against myocardial ischemia/reperfusion injury in transgenic mice. J Mol Cel Cardiol 1998 30 : 2281 2289.
4. Chen Z, Ho YS, Oberley TD et al. Overexpression of CuZnSOD in coronary vascular cells attenuates myocardial ischemia/reperfusion injury. Free Rad Biol Med 2000 29 : 589 596.
5. Yoshida T, Watanabe M, Engelman D et al. Transgenic mice overexpressing glutathione peroxidase are resistant to myocardial ischemia reperfusion injury. J Mol Cell Cardiol 1996 28 : 1759 1767.
6. Yoshida T, Maulik N, Engelman RM et al. Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury. Circulation 1997 96 : II-216 II-220.
7. Kajstura J, Cheng W, Reiss K et al. Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest 1996 74 : 86 107.
8. Gottlieb RA, Bureleson KO, Kloner RA. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest 1994 94 : 1621 1628.
9. Chen Z, Chua CC, Ho YS et al. Overexpression of bcl-2 attenuates apoptosis and protects the heart from ischemia/reperfusion injury. Am J Physiol 2001 280 : H2313 H2320.
10. Chua CC, Gao J, Ho YS et al. Overexpression of IAP-2 attenuates apoptosis and protects against myocardial ischemia/reperfusion injury in transgenic mice. Biochim Biophys Acta 2007 1773 : 577 583.
11. Chua CC, Gao J, Ho YS et al. Over-expression of a modified bifunctional apoptosis regulator protects against myocardial ischemia/reperfusion injury and doxorubicin-induced cardiotoxicity in transgenic mice. Cardiovas Res 2008 Oct 14 [Epub ahead of print].
12. Reiter RJ, Tang L, Garcia JJ. Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sci 1997 60 : 2255 2271.
13. Reiter RJ, Melchiorri D, Sewerynek E et al. A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res 1995 18 : 1 11.
14. Hardeland R, Reiter RJ, Poeggeler B et al. The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances. Neurosci Biobehav Rev 1993 17 : 347 357.
15. Pieri C, Marra M, Moroni F et al. Melatonin: A peroxyl radical scavenger more effective than vitamin. E Life Sci 1994 15 : PL271 PL276.
16. Tan DX, Manchester LC, Reiter RJ et al. Melatonin directly scavenges hydrogen peroxide: a potentially new metabolic pathway of melatonin biotransformation. Free Rad Biol Med 2000 29 : 1177 1185.
17. Tan DX, Manchester LC, Terron MP et al. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 2007 42 : 28 42.
18. Chen Z, Chua CC, Gao J et al. Protective effect of melatonin on myocardial infarction. Am J Physiol Heart Circ Physiol 2003 284 : H1618 H1624.
19. Sahna E, Parlakpinar H, Turkoz Y et al. Protective effects of melatonin on myocardial ischemia/reperfusion induced infarct size and oxidative changes. Physiol Res 2005 54 : 491 495.
20. Reiter RJ, Tan DX. Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart. Cardiovasc Res 2003 58 : 10 19.
21. Sahna E, Acet A, Ozer MK et al. Myocardial ischemia-reperfusion in rats: reduction of infarct size by either supplemental physiological or pharmacological doses of melatonin. J Pineal Res 2002 33 : 234 238.
22. Reiter RJ, Tan DX, Sainz RM et al. Melatonin protects the heart against both ischemia/reperfusion injury and chemotherapeutic drugs. Cardiovasc Drugs Ther 2002 16 : 5 6.
23. Szarzoi O, Asemu G, Vanacek J et al. Effects of melatonin on ischemia and reperfusion injury of the rat heart. Cardiovasc Drugs Ther 2001 15 : 251 257.
24. Salie R, Harper I, Cillie C et al. Melatonin protects against ischaemic-reperfusion myocardial damage. J Mol Cell Cardiol 2001 33 : 343 357.
25. Lagneaux C, Joyeux M, Demenge P et al. Protective effects of melatonin against ischemia-reperfusion injury in the isolated rat heart. Life Sci 2000 66 : 503 509.
26. Koh PO. Melatonin attenuates the focal cerebral ischemic injury by inhibiting the dissociation of pBad from 14-3-3. J Pineal Res 2008 44 : 101 106.
27. Kunduzova OR, Escourrou G, Seguelas MH et al. Prevention of apoptotic and necrotic cell death, caspase-3 activation, and renal dysfunction by melatonin after ischemia/reperfusion. FASEB J 2003 17 : 872 874.
28. Munoz-Casares FC, Padillo FJ, Briceno J et al. Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas. J Pineal Res 2006 40 : 195 203.
29. Kim SH, Lee SM. Cytoprotective effects of melatonin against necrosis and apoptosis induced by ischemia/reperfusion injury in rat liver. J Pineal Res 2008 44 : 165 171.
30. Rodriguez C, Mayo JC, Sainz RM et al. Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 2004 36 : 1 9.
31. Dziegiel P, Murawksa-Cialowicz E, Jethon Z et al. Melatonin stimulates the activity of protective antioxidative enzymes in myocardial cells of rats in the course of doxorubicin intoxication. J Pineal Res 2003 35 : 183 187.
32. Pablos MI, Agapito MT, Gutierrez R et al. Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chicks. J Pineal Res 1995 19 : 111 115.
33. Ho YS, Magnenat JL, Bronson RT et al. Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia. J Biol Chem 1997 272 : 16644 16651.
34. Liu X, Chen Z, Chua CC et al. Melatonin as an effective protector against doxorubicin-induced cardiotoxicity. Am J Physiol Heart Circ Physiol 2002 283 : H254 263.
35. Lochner A, Genade S, Davids A et al. Short- and long-term effects of melatonin on myocardial post-ischemic recovery. J Pineal Res 2006 40 : 56 63.
36. Andrabi SA, Sayeed I, Siemen D et al. Direct inhibition of mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin. FASEB J 2004 18 : 869 871.
37. Radogna F, Cristofanon S, Paternoster L et al. Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2. J Pineal Res 2008 44 : 316 325.