Structural insight of dopamine β-hydroxylase, a drug target for complex traits, and functional significance of exonic single nucleotide polymorphisms

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Kapoor, Abhijeet ^a   Shandilya, Manish ^a   Kundu, Suman ^a  

^a UNIVERSITY OF DELHI   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; ASPARAGINE; COPPER ION; CYSTEINE; DOPAMINE BETA MONOOXYGENASE; GLUTAMINE; LEUCINE; LYSINE; NEPICASTAT; PROLINE; COPPER; ENZYME INHIBITOR;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; DISULFIDE BOND; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; EXON; GENE MUTATION; HUMAN; HYDROGEN BOND; NUCLEOTIDE SEQUENCE; OLIGOMERIZATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STRUCTURE ANALYSIS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; PHYSICAL CHEMISTRY; PROTEIN MULTIMERIZATION; REPRODUCIBILITY; STRUCTURE ACTIVITY RELATION;

RATTUS;

ANIMALS; CATALYTIC DOMAIN; COPPER; DOPAMINE BETA-HYDROXYLASE; DRUG DESIGN; ENZYME INHIBITORS; EXONS; HUMANS; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; PHYSICOCHEMICAL PROCESSES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80054803830     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026509     Document Type: Article

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