The leukemia-specific fusion gene etv6/runx1 perturbs distinct key biological functions primarily by gene repression

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Fuka, Gerhard ^a   Kauer, Maximilian ^a   Kofler, Reinhard ^b   Haas, Oskar A ^c   Panzer Grümayer, Renate ^a,c  

^a CHILDREN'S CANCER RESEARCH INSTITUTE   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c ST ANNA CHILDREN S HOSPITAL   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR ETV6; TRANSCRIPTION FACTOR RUNX1; MESSENGER RNA; REPRESSOR PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR ETS; TRANSCRIPTOME;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CELL ACTIVATION; CELL ADHESION; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; ETV6 RUNX1 GENE; FUSION GENE; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE REPRESSION; GENE SILENCING; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LEUKEMIA CELL; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; CHILD; DNA MICROARRAY; GENE FUSION; GENETICS; IMMUNOLOGY; METABOLISM; PATHOLOGY; REPRODUCIBILITY; TUMOR CELL LINE;

CELL LINE, TUMOR; CHILD; CORE BINDING FACTOR ALPHA 2 SUBUNIT; GENE FUSION; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENE PROTEINS C-ETS; REPRESSOR PROTEINS; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTOME;

EID: 80054789892     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026348     Document Type: Article

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