-
1
-
-
0025853776
-
Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
-
Fakharzadeh S.S., et al. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J. 10 (1991) 1565-1569
-
(1991)
EMBO J.
, vol.10
, pp. 1565-1569
-
-
Fakharzadeh, S.S.1
-
2
-
-
14644437751
-
MDM2 is a central node in the p53 pathway: 12 years and counting
-
Bond G.L., et al. MDM2 is a central node in the p53 pathway: 12 years and counting. Curr. Cancer Drug Targets 5 (2005) 3-8
-
(2005)
Curr. Cancer Drug Targets
, vol.5
, pp. 3-8
-
-
Bond, G.L.1
-
3
-
-
14644417208
-
p53-independent activities of MDM2 and their relevance to cancer therapy
-
Zhang Z., et al. p53-independent activities of MDM2 and their relevance to cancer therapy. Curr. Cancer Drug Targets 5 (2005) 9-20
-
(2005)
Curr. Cancer Drug Targets
, vol.5
, pp. 9-20
-
-
Zhang, Z.1
-
4
-
-
33749334018
-
A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization
-
Aylon Y., et al. A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev. 20 (2006) 2687-2700
-
(2006)
Genes Dev.
, vol.20
, pp. 2687-2700
-
-
Aylon, Y.1
-
5
-
-
14644403700
-
MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy
-
Rayburn E., et al. MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy. Curr. Cancer Drug Targets 5 (2005) 27-41
-
(2005)
Curr. Cancer Drug Targets
, vol.5
, pp. 27-41
-
-
Rayburn, E.1
-
6
-
-
0028098165
-
Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas
-
Cordon-Cardo C., et al. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res. 54 (1994) 794-799
-
(1994)
Cancer Res.
, vol.54
, pp. 794-799
-
-
Cordon-Cardo, C.1
-
7
-
-
0036157247
-
Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methods
-
Lu M.L., et al. Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methods. Clin. Cancer Res. 8 (2002) 171-179
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 171-179
-
-
Lu, M.L.1
-
8
-
-
0345268720
-
Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis
-
Alt J.R., et al. Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis. EMBO J. 22 (2003) 1442-1450
-
(2003)
EMBO J.
, vol.22
, pp. 1442-1450
-
-
Alt, J.R.1
-
9
-
-
0033569422
-
Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
-
Eischen C.M., et al. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev. 13 (1999) 2658-2669
-
(1999)
Genes Dev.
, vol.13
, pp. 2658-2669
-
-
Eischen, C.M.1
-
10
-
-
0344654959
-
Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice
-
McDonnell T.J., et al. Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice. J. Pathol. 188 (1999) 322-328
-
(1999)
J. Pathol.
, vol.188
, pp. 322-328
-
-
McDonnell, T.J.1
-
11
-
-
0032417695
-
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis
-
Jones S.N., et al. Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 15608-15612
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 15608-15612
-
-
Jones, S.N.1
-
12
-
-
14644397961
-
MDM2 splice variants and their therapeutic implications
-
Harris L.C. MDM2 splice variants and their therapeutic implications. Curr. Cancer Drug Targets 5 (2005) 21-26
-
(2005)
Curr. Cancer Drug Targets
, vol.5
, pp. 21-26
-
-
Harris, L.C.1
-
13
-
-
0033580430
-
Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression
-
Carroll P.E., et al. Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression. Oncogene 18 (1999) 1935-1944
-
(1999)
Oncogene
, vol.18
, pp. 1935-1944
-
-
Carroll, P.E.1
-
14
-
-
14444281159
-
Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53
-
Lundgren K., et al. Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev. 11 (1997) 714-725
-
(1997)
Genes Dev.
, vol.11
, pp. 714-725
-
-
Lundgren, K.1
-
15
-
-
40449085773
-
Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells
-
Wang P., et al. Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells. Oncogene 27 (2008) 1590-1598
-
(2008)
Oncogene
, vol.27
, pp. 1590-1598
-
-
Wang, P.1
-
16
-
-
33745563861
-
Decreased Mdm2 expression inhibits tumor development induced by loss of ARF
-
Wang P., et al. Decreased Mdm2 expression inhibits tumor development induced by loss of ARF. Oncogene 25 (2006) 3708-3718
-
(2006)
Oncogene
, vol.25
, pp. 3708-3718
-
-
Wang, P.1
-
17
-
-
8844279091
-
Destructive cycles: the role of genomic instability and adaptation in carcinogenesis
-
Schneider B.L., et al. Destructive cycles: the role of genomic instability and adaptation in carcinogenesis. Carcinogenesis 25 (2004) 2033-2044
-
(2004)
Carcinogenesis
, vol.25
, pp. 2033-2044
-
-
Schneider, B.L.1
-
18
-
-
16444365598
-
The growth arrest function of the human oncoprotein mouse double minute-2 is disabled by downstream mutation in cancer cells
-
Zhou R., et al. The growth arrest function of the human oncoprotein mouse double minute-2 is disabled by downstream mutation in cancer cells. Cancer Res. 65 (2005) 1839-1848
-
(2005)
Cancer Res.
, vol.65
, pp. 1839-1848
-
-
Zhou, R.1
-
19
-
-
28444437051
-
MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein
-
Sdek P., et al. MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. Mol. Cell 20 (2005) 699-708
-
(2005)
Mol. Cell
, vol.20
, pp. 699-708
-
-
Sdek, P.1
-
20
-
-
0029028353
-
Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
-
Martin K., et al. Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature 375 (1995) 691-694
-
(1995)
Nature
, vol.375
, pp. 691-694
-
-
Martin, K.1
-
21
-
-
0029028354
-
Interaction between the retinoblastoma protein and the oncoprotein MDM2
-
Xiao Z.X., et al. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 375 (1995) 694-698
-
(1995)
Nature
, vol.375
, pp. 694-698
-
-
Xiao, Z.X.1
-
22
-
-
0141758306
-
Evolving intricacies and implications of E2F1 regulation
-
Mundle S.D., et al. Evolving intricacies and implications of E2F1 regulation. FASEB J. 17 (2003) 569-574
-
(2003)
FASEB J.
, vol.17
, pp. 569-574
-
-
Mundle, S.D.1
-
23
-
-
0037182756
-
Mdm2 inhibition of p53 induces E2F1 transactivation via p21
-
Wunderlich M., et al. Mdm2 inhibition of p53 induces E2F1 transactivation via p21. Oncogene 21 (2002) 4414-4421
-
(2002)
Oncogene
, vol.21
, pp. 4414-4421
-
-
Wunderlich, M.1
-
24
-
-
11144241617
-
The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth
-
Sdek P., et al. The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth. J. Biol. Chem. 279 (2004) 53317-53322
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 53317-53322
-
-
Sdek, P.1
-
25
-
-
19944431662
-
Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation
-
Uchida C., et al. Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. EMBO J. 24 (2005) 160-169
-
(2005)
EMBO J.
, vol.24
, pp. 160-169
-
-
Uchida, C.1
-
26
-
-
0029590161
-
MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest
-
Dubs-Poterszman M.C., et al. MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest. Oncogene 11 (1995) 2445-2449
-
(1995)
Oncogene
, vol.11
, pp. 2445-2449
-
-
Dubs-Poterszman, M.C.1
-
27
-
-
0032989098
-
Overproduction of MDM2 in vivo disrupts S phase independent of E2F1
-
Reinke V., et al. Overproduction of MDM2 in vivo disrupts S phase independent of E2F1. Cell Growth Differ. 10 (1999) 147-154
-
(1999)
Cell Growth Differ.
, vol.10
, pp. 147-154
-
-
Reinke, V.1
-
28
-
-
0037018275
-
Overexpression of mouse Mdm2 induces developmental phenotypes in Drosophila
-
Folberg-Blum A., et al. Overexpression of mouse Mdm2 induces developmental phenotypes in Drosophila. Oncogene 21 (2002) 2413-2417
-
(2002)
Oncogene
, vol.21
, pp. 2413-2417
-
-
Folberg-Blum, A.1
-
29
-
-
0034644731
-
A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2
-
Boyd M.T., et al. A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. J. Biol. Chem. 275 (2000) 31883-31890
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 31883-31890
-
-
Boyd, M.T.1
-
30
-
-
11844301301
-
Regulation of p53 and MDM2 activity by MTBP
-
Brady M., et al. Regulation of p53 and MDM2 activity by MTBP. Mol. Cell. Biol. 25 (2005) 545-553
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 545-553
-
-
Brady, M.1
-
31
-
-
41149133894
-
Mtbp haploinsufficiency in mice increases tumor metastasis
-
Iwakuma T., et al. Mtbp haploinsufficiency in mice increases tumor metastasis. Oncogene 27 (2008) 1813-1820
-
(2008)
Oncogene
, vol.27
, pp. 1813-1820
-
-
Iwakuma, T.1
-
32
-
-
0346243936
-
MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation
-
Jin Y., et al. MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation. EMBO J. 22 (2003) 6365-6377
-
(2003)
EMBO J.
, vol.22
, pp. 6365-6377
-
-
Jin, Y.1
-
33
-
-
1942437554
-
WAF1/CIP1, independent of p53
-
WAF1/CIP1, independent of p53. J. Biol. Chem. 279 (2004) 16000-16006
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 16000-16006
-
-
Zhang, Z.1
-
34
-
-
0242580250
-
DNA damage-induced MDMX degradation is mediated by MDM2
-
Kawai H., et al. DNA damage-induced MDMX degradation is mediated by MDM2. J. Biol. Chem. 278 (2003) 45946-45953
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 45946-45953
-
-
Kawai, H.1
-
35
-
-
0141866880
-
Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2
-
de Graaf P., et al. Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2. J. Biol. Chem. 278 (2003) 38315-38324
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 38315-38324
-
-
de Graaf, P.1
-
36
-
-
0042592947
-
MDM2 promotes ubiquitination and degradation of MDMX
-
Pan Y., et al. MDM2 promotes ubiquitination and degradation of MDMX. Mol. Cell. Biol. 23 (2003) 5113-5121
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 5113-5121
-
-
Pan, Y.1
-
37
-
-
38949093780
-
MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2
-
Jin Y., et al. MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2. Mol. Cell. Biol. 28 (2008) 1218-1229
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 1218-1229
-
-
Jin, Y.1
-
38
-
-
38049125552
-
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases
-
McCulloch S.D., et al. The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Cell Res. 18 (2008) 148-161
-
(2008)
Cell Res.
, vol.18
, pp. 148-161
-
-
McCulloch, S.D.1
-
39
-
-
53249147678
-
DNA polymerase epsilon: a polymerase of unusual size (and complexity)
-
Pursell Z.F., et al. DNA polymerase epsilon: a polymerase of unusual size (and complexity). Prog. Nucleic Acid Res. Mol. Biol. 82 (2008) 101-145
-
(2008)
Prog. Nucleic Acid Res. Mol. Biol.
, vol.82
, pp. 101-145
-
-
Pursell, Z.F.1
-
40
-
-
0034666178
-
MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase ε
-
Vlatkovic N., et al. MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase ε. Nucleic Acids Res. 28 (2000) 3581-3586
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 3581-3586
-
-
Vlatkovic, N.1
-
41
-
-
0038412776
-
Stimulation of human DNA polymerase ε by MDM2
-
Asahara H., et al. Stimulation of human DNA polymerase ε by MDM2. Nucleic Acids Res. 31 (2003) 2451-2459
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 2451-2459
-
-
Asahara, H.1
-
42
-
-
31544464325
-
Genetic and epigenetic interactions between folate and aging in carcinogenesis
-
Jang H., et al. Genetic and epigenetic interactions between folate and aging in carcinogenesis. J. Nutr. 135 (2005) 2967S-2971S
-
(2005)
J. Nutr.
, vol.135
-
-
Jang, H.1
-
43
-
-
53349173420
-
Folate and cancer prevention - where to next? Counterpoint
-
Ulrich C.M. Folate and cancer prevention - where to next? Counterpoint. Cancer Epidemiol. Biomarkers Prev. 17 (2008) 2226-2230
-
(2008)
Cancer Epidemiol. Biomarkers Prev.
, vol.17
, pp. 2226-2230
-
-
Ulrich, C.M.1
-
44
-
-
44849096848
-
MDM2 regulates dihydrofolate reductase activity through monoubiquitination
-
Maguire M., et al. MDM2 regulates dihydrofolate reductase activity through monoubiquitination. Cancer Res. 68 (2008) 3232-3242
-
(2008)
Cancer Res.
, vol.68
, pp. 3232-3242
-
-
Maguire, M.1
-
45
-
-
0344708478
-
Anticancer antifolates: current status and future directions
-
McGuire J.J. Anticancer antifolates: current status and future directions. Curr. Pharm. Des. 9 (2003) 2593-2613
-
(2003)
Curr. Pharm. Des.
, vol.9
, pp. 2593-2613
-
-
McGuire, J.J.1
-
46
-
-
49549117370
-
A tale of too many centrosomes
-
Acilan C., et al. A tale of too many centrosomes. Cell 134 (2008) 572-575
-
(2008)
Cell
, vol.134
, pp. 572-575
-
-
Acilan, C.1
-
47
-
-
38949124679
-
MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice
-
Matijasevic Z., et al. MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice. Mol. Cell. Biol. 28 (2008) 1265-1273
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 1265-1273
-
-
Matijasevic, Z.1
-
48
-
-
21444444598
-
Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair
-
Alt J.R., et al. Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair. J. Biol. Chem. 280 (2005) 18771-18781
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 18771-18781
-
-
Alt, J.R.1
-
49
-
-
47949105325
-
Mdm2 promotes genetic instability and transformation independent of p53
-
Bouska A., et al. Mdm2 promotes genetic instability and transformation independent of p53. Mol. Cell. Biol. 28 (2008) 4862-4874
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 4862-4874
-
-
Bouska, A.1
-
50
-
-
31144471460
-
The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control
-
Zhang Y., et al. The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control. Cell Res. 16 (2006) 45-54
-
(2006)
Cell Res.
, vol.16
, pp. 45-54
-
-
Zhang, Y.1
-
51
-
-
0034649503
-
ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation
-
de Toledo S.M., et al. ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation. Oncogene 19 (2000) 6185-6193
-
(2000)
Oncogene
, vol.19
, pp. 6185-6193
-
-
de Toledo, S.M.1
-
52
-
-
3242880237
-
The emerging role of E2F-1 in the DNA damage response and checkpoint control
-
Stevens C., et al. The emerging role of E2F-1 in the DNA damage response and checkpoint control. DNA Repair (Amst.) 3 (2004) 1071-1079
-
(2004)
DNA Repair (Amst.)
, vol.3
, pp. 1071-1079
-
-
Stevens, C.1
-
53
-
-
33747382343
-
Cellular functions of TIP60
-
Sapountzi V., et al. Cellular functions of TIP60. Int. J. Biochem. Cell Biol. 38 (2006) 1496-1509
-
(2006)
Int. J. Biochem. Cell Biol.
, vol.38
, pp. 1496-1509
-
-
Sapountzi, V.1
-
54
-
-
0037007236
-
Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation
-
Legube G., et al. Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation. EMBO J. 21 (2002) 1704-1712
-
(2002)
EMBO J.
, vol.21
, pp. 1704-1712
-
-
Legube, G.1
-
55
-
-
4444370139
-
Apoptosis and genomic instability
-
Zhivotovsky B., et al. Apoptosis and genomic instability. Nat. Rev. Mol. Cell Biol. 5 (2004) 752-762
-
(2004)
Nat. Rev. Mol. Cell Biol.
, vol.5
, pp. 752-762
-
-
Zhivotovsky, B.1
-
56
-
-
0141482040
-
Antisense therapy targeting MDM2 oncogene in prostate cancer: effects on proliferation, apoptosis, multiple gene expression, and chemotherapy
-
Zhang Z., et al. Antisense therapy targeting MDM2 oncogene in prostate cancer: effects on proliferation, apoptosis, multiple gene expression, and chemotherapy. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 11636-11641
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 11636-11641
-
-
Zhang, Z.1
-
57
-
-
0033998439
-
Apoptotic and growth-promoting activity of E2F modulated by MDM2
-
Loughran O., et al. Apoptotic and growth-promoting activity of E2F modulated by MDM2. Mol. Cell. Biol. 20 (2000) 2186-2197
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 2186-2197
-
-
Loughran, O.1
-
58
-
-
85047696105
-
The mdm2 proto-oncogene sensitizes human medullary thyroid carcinoma cells to ionizing radiation
-
Dilla T., et al. The mdm2 proto-oncogene sensitizes human medullary thyroid carcinoma cells to ionizing radiation. Oncogene 21 (2002) 2376-2386
-
(2002)
Oncogene
, vol.21
, pp. 2376-2386
-
-
Dilla, T.1
-
59
-
-
34249303144
-
Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1
-
Ambrosini G., et al. Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1. Oncogene 26 (2007) 3473-3481
-
(2007)
Oncogene
, vol.26
, pp. 3473-3481
-
-
Ambrosini, G.1
-
60
-
-
51649088367
-
E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines
-
Kitagawa M., et al. E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines. Oncogene 27 (2008) 5303-5314
-
(2008)
Oncogene
, vol.27
, pp. 5303-5314
-
-
Kitagawa, M.1
-
61
-
-
54949091946
-
The p53 family and programmed cell death
-
Pietsch E.C., et al. The p53 family and programmed cell death. Oncogene 27 (2008) 6507-6521
-
(2008)
Oncogene
, vol.27
, pp. 6507-6521
-
-
Pietsch, E.C.1
-
62
-
-
0034609798
-
Role for the p53 homologue p73 in E2F-1-induced apoptosis
-
Irwin M., et al. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature 407 (2000) 645-648
-
(2000)
Nature
, vol.407
, pp. 645-648
-
-
Irwin, M.1
-
63
-
-
0037169519
-
The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63
-
Calabro V., et al. The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63. J. Biol. Chem. 277 (2002) 2674-2681
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 2674-2681
-
-
Calabro, V.1
-
64
-
-
0034921151
-
Regulation of p63 function by Mdm2 and MdmX
-
Kadakia M., et al. Regulation of p63 function by Mdm2 and MdmX. DNA Cell Biol. 20 (2001) 321-330
-
(2001)
DNA Cell Biol.
, vol.20
, pp. 321-330
-
-
Kadakia, M.1
-
65
-
-
0033602462
-
Inactivation of the p53-homologue p73 by the mdm2-oncoprotein
-
Dobbelstein M., et al. Inactivation of the p53-homologue p73 by the mdm2-oncoprotein. Oncogene 18 (1999) 2101-2106
-
(1999)
Oncogene
, vol.18
, pp. 2101-2106
-
-
Dobbelstein, M.1
-
66
-
-
0032961828
-
MDM2 suppresses p73 function without promoting p73 degradation
-
Zeng X., et al. MDM2 suppresses p73 function without promoting p73 degradation. Mol. Cell. Biol. 19 (1999) 3257-3266
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 3257-3266
-
-
Zeng, X.1
-
67
-
-
0033615084
-
MDM2 and MDMX bind and stabilize the p53-related protein p73
-
Ongkeko W.M., et al. MDM2 and MDMX bind and stabilize the p53-related protein p73. Curr. Biol. 9 (1999) 829-832
-
(1999)
Curr. Biol.
, vol.9
, pp. 829-832
-
-
Ongkeko, W.M.1
-
68
-
-
33845920314
-
Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function
-
Watson I.R., et al. Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function. J. Biol. Chem. 281 (2006) 34096-34103
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 34096-34103
-
-
Watson, I.R.1
-
69
-
-
50649108215
-
TIP60 represses transcriptional activity of p73β via an MDM2-bridged ternary complex
-
Kim J.W., et al. TIP60 represses transcriptional activity of p73β via an MDM2-bridged ternary complex. J. Biol. Chem. 283 (2008) 20077-20086
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 20077-20086
-
-
Kim, J.W.1
-
70
-
-
33646825822
-
p19ras interacts with and activates p73 by involving the MDM2 protein
-
Jeong M.H., et al. p19ras interacts with and activates p73 by involving the MDM2 protein. J. Biol. Chem. 281 (2006) 8707-8715
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 8707-8715
-
-
Jeong, M.H.1
-
71
-
-
38949199337
-
HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function
-
Lau L.M., et al. HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function. Oncogene 27 (2008) 997-1003
-
(2008)
Oncogene
, vol.27
, pp. 997-1003
-
-
Lau, L.M.1
-
72
-
-
11144357466
-
IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
-
Hu M.C., et al. IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117 (2004) 225-237
-
(2004)
Cell
, vol.117
, pp. 225-237
-
-
Hu, M.C.1
-
73
-
-
38849139580
-
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
-
Yang J.Y., et al. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat. Cell Biol. 10 (2008) 138-148
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 138-148
-
-
Yang, J.Y.1
-
74
-
-
13944249521
-
Cytokine overexpression and constitutive NFκB in cancer
-
Lu T., et al. Cytokine overexpression and constitutive NFκB in cancer. Cell Cycle 3 (2004) 1114-1117
-
(2004)
Cell Cycle
, vol.3
, pp. 1114-1117
-
-
Lu, T.1
-
75
-
-
0036565875
-
MDM2 induces NF-κB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia
-
Gu L., et al. MDM2 induces NF-κB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia. Blood 99 (2002) 3367-3375
-
(2002)
Blood
, vol.99
, pp. 3367-3375
-
-
Gu, L.1
-
76
-
-
42549095061
-
MDM2 displays differential activities dependent upon the activation status of NFκB
-
Cheney M.D., et al. MDM2 displays differential activities dependent upon the activation status of NFκB. Cancer Biol. Ther. 7 (2008) 38-44
-
(2008)
Cancer Biol. Ther.
, vol.7
, pp. 38-44
-
-
Cheney, M.D.1
-
77
-
-
53649093334
-
Mdm2 exerts pro-apoptotic activities by antagonizing insulin-like growth factor-I-mediated survival
-
Froment P., et al. Mdm2 exerts pro-apoptotic activities by antagonizing insulin-like growth factor-I-mediated survival. Cell Cycle 7 (2008) 3098-3103
-
(2008)
Cell Cycle
, vol.7
, pp. 3098-3103
-
-
Froment, P.1
-
78
-
-
35148837581
-
Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway - therapeutic perspectives in cancer
-
Tao Y., et al. Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway - therapeutic perspectives in cancer. Nat. Clin. Pract. Oncol. 4 (2007) 591-602
-
(2007)
Nat. Clin. Pract. Oncol.
, vol.4
, pp. 591-602
-
-
Tao, Y.1
-
79
-
-
0037816235
-
Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor
-
Girnita L., et al. Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 8247-8252
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 8247-8252
-
-
Girnita, L.1
-
80
-
-
57049114832
-
The genetics of the p53 pathway, apoptosis and cancer therapy
-
Vazquez A., et al. The genetics of the p53 pathway, apoptosis and cancer therapy. Nat. Rev. Drug Discov. 7 (2008) 979-987
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 979-987
-
-
Vazquez, A.1
|