메뉴 건너뛰기




Volumn 34, Issue 6, 2009, Pages 279-286

Murine double minute 2: p53-independent roads lead to genome instability or death

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; NUTLIN 3; PACLITAXEL; PROTEIN MDM2; PROTEIN P53;

EID: 66949142488     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2009.02.006     Document Type: Review
Times cited : (54)

References (80)
  • 1
    • 0025853776 scopus 로고
    • Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
    • Fakharzadeh S.S., et al. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J. 10 (1991) 1565-1569
    • (1991) EMBO J. , vol.10 , pp. 1565-1569
    • Fakharzadeh, S.S.1
  • 2
    • 14644437751 scopus 로고    scopus 로고
    • MDM2 is a central node in the p53 pathway: 12 years and counting
    • Bond G.L., et al. MDM2 is a central node in the p53 pathway: 12 years and counting. Curr. Cancer Drug Targets 5 (2005) 3-8
    • (2005) Curr. Cancer Drug Targets , vol.5 , pp. 3-8
    • Bond, G.L.1
  • 3
    • 14644417208 scopus 로고    scopus 로고
    • p53-independent activities of MDM2 and their relevance to cancer therapy
    • Zhang Z., et al. p53-independent activities of MDM2 and their relevance to cancer therapy. Curr. Cancer Drug Targets 5 (2005) 9-20
    • (2005) Curr. Cancer Drug Targets , vol.5 , pp. 9-20
    • Zhang, Z.1
  • 4
    • 33749334018 scopus 로고    scopus 로고
    • A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization
    • Aylon Y., et al. A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev. 20 (2006) 2687-2700
    • (2006) Genes Dev. , vol.20 , pp. 2687-2700
    • Aylon, Y.1
  • 5
    • 14644403700 scopus 로고    scopus 로고
    • MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy
    • Rayburn E., et al. MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy. Curr. Cancer Drug Targets 5 (2005) 27-41
    • (2005) Curr. Cancer Drug Targets , vol.5 , pp. 27-41
    • Rayburn, E.1
  • 6
    • 0028098165 scopus 로고
    • Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas
    • Cordon-Cardo C., et al. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res. 54 (1994) 794-799
    • (1994) Cancer Res. , vol.54 , pp. 794-799
    • Cordon-Cardo, C.1
  • 7
    • 0036157247 scopus 로고    scopus 로고
    • Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methods
    • Lu M.L., et al. Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methods. Clin. Cancer Res. 8 (2002) 171-179
    • (2002) Clin. Cancer Res. , vol.8 , pp. 171-179
    • Lu, M.L.1
  • 8
    • 0345268720 scopus 로고    scopus 로고
    • Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis
    • Alt J.R., et al. Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis. EMBO J. 22 (2003) 1442-1450
    • (2003) EMBO J. , vol.22 , pp. 1442-1450
    • Alt, J.R.1
  • 9
    • 0033569422 scopus 로고    scopus 로고
    • Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
    • Eischen C.M., et al. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev. 13 (1999) 2658-2669
    • (1999) Genes Dev. , vol.13 , pp. 2658-2669
    • Eischen, C.M.1
  • 10
    • 0344654959 scopus 로고    scopus 로고
    • Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice
    • McDonnell T.J., et al. Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice. J. Pathol. 188 (1999) 322-328
    • (1999) J. Pathol. , vol.188 , pp. 322-328
    • McDonnell, T.J.1
  • 11
    • 0032417695 scopus 로고    scopus 로고
    • Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis
    • Jones S.N., et al. Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 15608-15612
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 15608-15612
    • Jones, S.N.1
  • 12
    • 14644397961 scopus 로고    scopus 로고
    • MDM2 splice variants and their therapeutic implications
    • Harris L.C. MDM2 splice variants and their therapeutic implications. Curr. Cancer Drug Targets 5 (2005) 21-26
    • (2005) Curr. Cancer Drug Targets , vol.5 , pp. 21-26
    • Harris, L.C.1
  • 13
    • 0033580430 scopus 로고    scopus 로고
    • Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression
    • Carroll P.E., et al. Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression. Oncogene 18 (1999) 1935-1944
    • (1999) Oncogene , vol.18 , pp. 1935-1944
    • Carroll, P.E.1
  • 14
    • 14444281159 scopus 로고    scopus 로고
    • Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53
    • Lundgren K., et al. Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev. 11 (1997) 714-725
    • (1997) Genes Dev. , vol.11 , pp. 714-725
    • Lundgren, K.1
  • 15
    • 40449085773 scopus 로고    scopus 로고
    • Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells
    • Wang P., et al. Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells. Oncogene 27 (2008) 1590-1598
    • (2008) Oncogene , vol.27 , pp. 1590-1598
    • Wang, P.1
  • 16
    • 33745563861 scopus 로고    scopus 로고
    • Decreased Mdm2 expression inhibits tumor development induced by loss of ARF
    • Wang P., et al. Decreased Mdm2 expression inhibits tumor development induced by loss of ARF. Oncogene 25 (2006) 3708-3718
    • (2006) Oncogene , vol.25 , pp. 3708-3718
    • Wang, P.1
  • 17
    • 8844279091 scopus 로고    scopus 로고
    • Destructive cycles: the role of genomic instability and adaptation in carcinogenesis
    • Schneider B.L., et al. Destructive cycles: the role of genomic instability and adaptation in carcinogenesis. Carcinogenesis 25 (2004) 2033-2044
    • (2004) Carcinogenesis , vol.25 , pp. 2033-2044
    • Schneider, B.L.1
  • 18
    • 16444365598 scopus 로고    scopus 로고
    • The growth arrest function of the human oncoprotein mouse double minute-2 is disabled by downstream mutation in cancer cells
    • Zhou R., et al. The growth arrest function of the human oncoprotein mouse double minute-2 is disabled by downstream mutation in cancer cells. Cancer Res. 65 (2005) 1839-1848
    • (2005) Cancer Res. , vol.65 , pp. 1839-1848
    • Zhou, R.1
  • 19
    • 28444437051 scopus 로고    scopus 로고
    • MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein
    • Sdek P., et al. MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. Mol. Cell 20 (2005) 699-708
    • (2005) Mol. Cell , vol.20 , pp. 699-708
    • Sdek, P.1
  • 20
    • 0029028353 scopus 로고
    • Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
    • Martin K., et al. Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature 375 (1995) 691-694
    • (1995) Nature , vol.375 , pp. 691-694
    • Martin, K.1
  • 21
    • 0029028354 scopus 로고
    • Interaction between the retinoblastoma protein and the oncoprotein MDM2
    • Xiao Z.X., et al. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 375 (1995) 694-698
    • (1995) Nature , vol.375 , pp. 694-698
    • Xiao, Z.X.1
  • 22
    • 0141758306 scopus 로고    scopus 로고
    • Evolving intricacies and implications of E2F1 regulation
    • Mundle S.D., et al. Evolving intricacies and implications of E2F1 regulation. FASEB J. 17 (2003) 569-574
    • (2003) FASEB J. , vol.17 , pp. 569-574
    • Mundle, S.D.1
  • 23
    • 0037182756 scopus 로고    scopus 로고
    • Mdm2 inhibition of p53 induces E2F1 transactivation via p21
    • Wunderlich M., et al. Mdm2 inhibition of p53 induces E2F1 transactivation via p21. Oncogene 21 (2002) 4414-4421
    • (2002) Oncogene , vol.21 , pp. 4414-4421
    • Wunderlich, M.1
  • 24
    • 11144241617 scopus 로고    scopus 로고
    • The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth
    • Sdek P., et al. The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth. J. Biol. Chem. 279 (2004) 53317-53322
    • (2004) J. Biol. Chem. , vol.279 , pp. 53317-53322
    • Sdek, P.1
  • 25
    • 19944431662 scopus 로고    scopus 로고
    • Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation
    • Uchida C., et al. Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. EMBO J. 24 (2005) 160-169
    • (2005) EMBO J. , vol.24 , pp. 160-169
    • Uchida, C.1
  • 26
    • 0029590161 scopus 로고
    • MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest
    • Dubs-Poterszman M.C., et al. MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest. Oncogene 11 (1995) 2445-2449
    • (1995) Oncogene , vol.11 , pp. 2445-2449
    • Dubs-Poterszman, M.C.1
  • 27
    • 0032989098 scopus 로고    scopus 로고
    • Overproduction of MDM2 in vivo disrupts S phase independent of E2F1
    • Reinke V., et al. Overproduction of MDM2 in vivo disrupts S phase independent of E2F1. Cell Growth Differ. 10 (1999) 147-154
    • (1999) Cell Growth Differ. , vol.10 , pp. 147-154
    • Reinke, V.1
  • 28
    • 0037018275 scopus 로고    scopus 로고
    • Overexpression of mouse Mdm2 induces developmental phenotypes in Drosophila
    • Folberg-Blum A., et al. Overexpression of mouse Mdm2 induces developmental phenotypes in Drosophila. Oncogene 21 (2002) 2413-2417
    • (2002) Oncogene , vol.21 , pp. 2413-2417
    • Folberg-Blum, A.1
  • 29
    • 0034644731 scopus 로고    scopus 로고
    • A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2
    • Boyd M.T., et al. A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. J. Biol. Chem. 275 (2000) 31883-31890
    • (2000) J. Biol. Chem. , vol.275 , pp. 31883-31890
    • Boyd, M.T.1
  • 30
    • 11844301301 scopus 로고    scopus 로고
    • Regulation of p53 and MDM2 activity by MTBP
    • Brady M., et al. Regulation of p53 and MDM2 activity by MTBP. Mol. Cell. Biol. 25 (2005) 545-553
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 545-553
    • Brady, M.1
  • 31
    • 41149133894 scopus 로고    scopus 로고
    • Mtbp haploinsufficiency in mice increases tumor metastasis
    • Iwakuma T., et al. Mtbp haploinsufficiency in mice increases tumor metastasis. Oncogene 27 (2008) 1813-1820
    • (2008) Oncogene , vol.27 , pp. 1813-1820
    • Iwakuma, T.1
  • 32
    • 0346243936 scopus 로고    scopus 로고
    • MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation
    • Jin Y., et al. MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation. EMBO J. 22 (2003) 6365-6377
    • (2003) EMBO J. , vol.22 , pp. 6365-6377
    • Jin, Y.1
  • 33
    • 1942437554 scopus 로고    scopus 로고
    • WAF1/CIP1, independent of p53
    • WAF1/CIP1, independent of p53. J. Biol. Chem. 279 (2004) 16000-16006
    • (2004) J. Biol. Chem. , vol.279 , pp. 16000-16006
    • Zhang, Z.1
  • 34
    • 0242580250 scopus 로고    scopus 로고
    • DNA damage-induced MDMX degradation is mediated by MDM2
    • Kawai H., et al. DNA damage-induced MDMX degradation is mediated by MDM2. J. Biol. Chem. 278 (2003) 45946-45953
    • (2003) J. Biol. Chem. , vol.278 , pp. 45946-45953
    • Kawai, H.1
  • 35
    • 0141866880 scopus 로고    scopus 로고
    • Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2
    • de Graaf P., et al. Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2. J. Biol. Chem. 278 (2003) 38315-38324
    • (2003) J. Biol. Chem. , vol.278 , pp. 38315-38324
    • de Graaf, P.1
  • 36
    • 0042592947 scopus 로고    scopus 로고
    • MDM2 promotes ubiquitination and degradation of MDMX
    • Pan Y., et al. MDM2 promotes ubiquitination and degradation of MDMX. Mol. Cell. Biol. 23 (2003) 5113-5121
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 5113-5121
    • Pan, Y.1
  • 37
    • 38949093780 scopus 로고    scopus 로고
    • MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2
    • Jin Y., et al. MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2. Mol. Cell. Biol. 28 (2008) 1218-1229
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 1218-1229
    • Jin, Y.1
  • 38
    • 38049125552 scopus 로고    scopus 로고
    • The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases
    • McCulloch S.D., et al. The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Cell Res. 18 (2008) 148-161
    • (2008) Cell Res. , vol.18 , pp. 148-161
    • McCulloch, S.D.1
  • 39
    • 53249147678 scopus 로고    scopus 로고
    • DNA polymerase epsilon: a polymerase of unusual size (and complexity)
    • Pursell Z.F., et al. DNA polymerase epsilon: a polymerase of unusual size (and complexity). Prog. Nucleic Acid Res. Mol. Biol. 82 (2008) 101-145
    • (2008) Prog. Nucleic Acid Res. Mol. Biol. , vol.82 , pp. 101-145
    • Pursell, Z.F.1
  • 40
    • 0034666178 scopus 로고    scopus 로고
    • MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase ε
    • Vlatkovic N., et al. MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase ε. Nucleic Acids Res. 28 (2000) 3581-3586
    • (2000) Nucleic Acids Res. , vol.28 , pp. 3581-3586
    • Vlatkovic, N.1
  • 41
    • 0038412776 scopus 로고    scopus 로고
    • Stimulation of human DNA polymerase ε by MDM2
    • Asahara H., et al. Stimulation of human DNA polymerase ε by MDM2. Nucleic Acids Res. 31 (2003) 2451-2459
    • (2003) Nucleic Acids Res. , vol.31 , pp. 2451-2459
    • Asahara, H.1
  • 42
    • 31544464325 scopus 로고    scopus 로고
    • Genetic and epigenetic interactions between folate and aging in carcinogenesis
    • Jang H., et al. Genetic and epigenetic interactions between folate and aging in carcinogenesis. J. Nutr. 135 (2005) 2967S-2971S
    • (2005) J. Nutr. , vol.135
    • Jang, H.1
  • 43
    • 53349173420 scopus 로고    scopus 로고
    • Folate and cancer prevention - where to next? Counterpoint
    • Ulrich C.M. Folate and cancer prevention - where to next? Counterpoint. Cancer Epidemiol. Biomarkers Prev. 17 (2008) 2226-2230
    • (2008) Cancer Epidemiol. Biomarkers Prev. , vol.17 , pp. 2226-2230
    • Ulrich, C.M.1
  • 44
    • 44849096848 scopus 로고    scopus 로고
    • MDM2 regulates dihydrofolate reductase activity through monoubiquitination
    • Maguire M., et al. MDM2 regulates dihydrofolate reductase activity through monoubiquitination. Cancer Res. 68 (2008) 3232-3242
    • (2008) Cancer Res. , vol.68 , pp. 3232-3242
    • Maguire, M.1
  • 45
    • 0344708478 scopus 로고    scopus 로고
    • Anticancer antifolates: current status and future directions
    • McGuire J.J. Anticancer antifolates: current status and future directions. Curr. Pharm. Des. 9 (2003) 2593-2613
    • (2003) Curr. Pharm. Des. , vol.9 , pp. 2593-2613
    • McGuire, J.J.1
  • 46
    • 49549117370 scopus 로고    scopus 로고
    • A tale of too many centrosomes
    • Acilan C., et al. A tale of too many centrosomes. Cell 134 (2008) 572-575
    • (2008) Cell , vol.134 , pp. 572-575
    • Acilan, C.1
  • 47
    • 38949124679 scopus 로고    scopus 로고
    • MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice
    • Matijasevic Z., et al. MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice. Mol. Cell. Biol. 28 (2008) 1265-1273
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 1265-1273
    • Matijasevic, Z.1
  • 48
    • 21444444598 scopus 로고    scopus 로고
    • Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair
    • Alt J.R., et al. Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair. J. Biol. Chem. 280 (2005) 18771-18781
    • (2005) J. Biol. Chem. , vol.280 , pp. 18771-18781
    • Alt, J.R.1
  • 49
    • 47949105325 scopus 로고    scopus 로고
    • Mdm2 promotes genetic instability and transformation independent of p53
    • Bouska A., et al. Mdm2 promotes genetic instability and transformation independent of p53. Mol. Cell. Biol. 28 (2008) 4862-4874
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 4862-4874
    • Bouska, A.1
  • 50
    • 31144471460 scopus 로고    scopus 로고
    • The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control
    • Zhang Y., et al. The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control. Cell Res. 16 (2006) 45-54
    • (2006) Cell Res. , vol.16 , pp. 45-54
    • Zhang, Y.1
  • 51
    • 0034649503 scopus 로고    scopus 로고
    • ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation
    • de Toledo S.M., et al. ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation. Oncogene 19 (2000) 6185-6193
    • (2000) Oncogene , vol.19 , pp. 6185-6193
    • de Toledo, S.M.1
  • 52
    • 3242880237 scopus 로고    scopus 로고
    • The emerging role of E2F-1 in the DNA damage response and checkpoint control
    • Stevens C., et al. The emerging role of E2F-1 in the DNA damage response and checkpoint control. DNA Repair (Amst.) 3 (2004) 1071-1079
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 1071-1079
    • Stevens, C.1
  • 53
    • 33747382343 scopus 로고    scopus 로고
    • Cellular functions of TIP60
    • Sapountzi V., et al. Cellular functions of TIP60. Int. J. Biochem. Cell Biol. 38 (2006) 1496-1509
    • (2006) Int. J. Biochem. Cell Biol. , vol.38 , pp. 1496-1509
    • Sapountzi, V.1
  • 54
    • 0037007236 scopus 로고    scopus 로고
    • Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation
    • Legube G., et al. Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation. EMBO J. 21 (2002) 1704-1712
    • (2002) EMBO J. , vol.21 , pp. 1704-1712
    • Legube, G.1
  • 55
    • 4444370139 scopus 로고    scopus 로고
    • Apoptosis and genomic instability
    • Zhivotovsky B., et al. Apoptosis and genomic instability. Nat. Rev. Mol. Cell Biol. 5 (2004) 752-762
    • (2004) Nat. Rev. Mol. Cell Biol. , vol.5 , pp. 752-762
    • Zhivotovsky, B.1
  • 56
    • 0141482040 scopus 로고    scopus 로고
    • Antisense therapy targeting MDM2 oncogene in prostate cancer: effects on proliferation, apoptosis, multiple gene expression, and chemotherapy
    • Zhang Z., et al. Antisense therapy targeting MDM2 oncogene in prostate cancer: effects on proliferation, apoptosis, multiple gene expression, and chemotherapy. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 11636-11641
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 11636-11641
    • Zhang, Z.1
  • 57
    • 0033998439 scopus 로고    scopus 로고
    • Apoptotic and growth-promoting activity of E2F modulated by MDM2
    • Loughran O., et al. Apoptotic and growth-promoting activity of E2F modulated by MDM2. Mol. Cell. Biol. 20 (2000) 2186-2197
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2186-2197
    • Loughran, O.1
  • 58
    • 85047696105 scopus 로고    scopus 로고
    • The mdm2 proto-oncogene sensitizes human medullary thyroid carcinoma cells to ionizing radiation
    • Dilla T., et al. The mdm2 proto-oncogene sensitizes human medullary thyroid carcinoma cells to ionizing radiation. Oncogene 21 (2002) 2376-2386
    • (2002) Oncogene , vol.21 , pp. 2376-2386
    • Dilla, T.1
  • 59
    • 34249303144 scopus 로고    scopus 로고
    • Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1
    • Ambrosini G., et al. Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1. Oncogene 26 (2007) 3473-3481
    • (2007) Oncogene , vol.26 , pp. 3473-3481
    • Ambrosini, G.1
  • 60
    • 51649088367 scopus 로고    scopus 로고
    • E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines
    • Kitagawa M., et al. E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines. Oncogene 27 (2008) 5303-5314
    • (2008) Oncogene , vol.27 , pp. 5303-5314
    • Kitagawa, M.1
  • 61
    • 54949091946 scopus 로고    scopus 로고
    • The p53 family and programmed cell death
    • Pietsch E.C., et al. The p53 family and programmed cell death. Oncogene 27 (2008) 6507-6521
    • (2008) Oncogene , vol.27 , pp. 6507-6521
    • Pietsch, E.C.1
  • 62
    • 0034609798 scopus 로고    scopus 로고
    • Role for the p53 homologue p73 in E2F-1-induced apoptosis
    • Irwin M., et al. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature 407 (2000) 645-648
    • (2000) Nature , vol.407 , pp. 645-648
    • Irwin, M.1
  • 63
    • 0037169519 scopus 로고    scopus 로고
    • The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63
    • Calabro V., et al. The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63. J. Biol. Chem. 277 (2002) 2674-2681
    • (2002) J. Biol. Chem. , vol.277 , pp. 2674-2681
    • Calabro, V.1
  • 64
    • 0034921151 scopus 로고    scopus 로고
    • Regulation of p63 function by Mdm2 and MdmX
    • Kadakia M., et al. Regulation of p63 function by Mdm2 and MdmX. DNA Cell Biol. 20 (2001) 321-330
    • (2001) DNA Cell Biol. , vol.20 , pp. 321-330
    • Kadakia, M.1
  • 65
    • 0033602462 scopus 로고    scopus 로고
    • Inactivation of the p53-homologue p73 by the mdm2-oncoprotein
    • Dobbelstein M., et al. Inactivation of the p53-homologue p73 by the mdm2-oncoprotein. Oncogene 18 (1999) 2101-2106
    • (1999) Oncogene , vol.18 , pp. 2101-2106
    • Dobbelstein, M.1
  • 66
    • 0032961828 scopus 로고    scopus 로고
    • MDM2 suppresses p73 function without promoting p73 degradation
    • Zeng X., et al. MDM2 suppresses p73 function without promoting p73 degradation. Mol. Cell. Biol. 19 (1999) 3257-3266
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3257-3266
    • Zeng, X.1
  • 67
    • 0033615084 scopus 로고    scopus 로고
    • MDM2 and MDMX bind and stabilize the p53-related protein p73
    • Ongkeko W.M., et al. MDM2 and MDMX bind and stabilize the p53-related protein p73. Curr. Biol. 9 (1999) 829-832
    • (1999) Curr. Biol. , vol.9 , pp. 829-832
    • Ongkeko, W.M.1
  • 68
    • 33845920314 scopus 로고    scopus 로고
    • Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function
    • Watson I.R., et al. Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function. J. Biol. Chem. 281 (2006) 34096-34103
    • (2006) J. Biol. Chem. , vol.281 , pp. 34096-34103
    • Watson, I.R.1
  • 69
    • 50649108215 scopus 로고    scopus 로고
    • TIP60 represses transcriptional activity of p73β via an MDM2-bridged ternary complex
    • Kim J.W., et al. TIP60 represses transcriptional activity of p73β via an MDM2-bridged ternary complex. J. Biol. Chem. 283 (2008) 20077-20086
    • (2008) J. Biol. Chem. , vol.283 , pp. 20077-20086
    • Kim, J.W.1
  • 70
    • 33646825822 scopus 로고    scopus 로고
    • p19ras interacts with and activates p73 by involving the MDM2 protein
    • Jeong M.H., et al. p19ras interacts with and activates p73 by involving the MDM2 protein. J. Biol. Chem. 281 (2006) 8707-8715
    • (2006) J. Biol. Chem. , vol.281 , pp. 8707-8715
    • Jeong, M.H.1
  • 71
    • 38949199337 scopus 로고    scopus 로고
    • HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function
    • Lau L.M., et al. HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function. Oncogene 27 (2008) 997-1003
    • (2008) Oncogene , vol.27 , pp. 997-1003
    • Lau, L.M.1
  • 72
    • 11144357466 scopus 로고    scopus 로고
    • IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
    • Hu M.C., et al. IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117 (2004) 225-237
    • (2004) Cell , vol.117 , pp. 225-237
    • Hu, M.C.1
  • 73
    • 38849139580 scopus 로고    scopus 로고
    • ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
    • Yang J.Y., et al. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat. Cell Biol. 10 (2008) 138-148
    • (2008) Nat. Cell Biol. , vol.10 , pp. 138-148
    • Yang, J.Y.1
  • 74
    • 13944249521 scopus 로고    scopus 로고
    • Cytokine overexpression and constitutive NFκB in cancer
    • Lu T., et al. Cytokine overexpression and constitutive NFκB in cancer. Cell Cycle 3 (2004) 1114-1117
    • (2004) Cell Cycle , vol.3 , pp. 1114-1117
    • Lu, T.1
  • 75
    • 0036565875 scopus 로고    scopus 로고
    • MDM2 induces NF-κB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia
    • Gu L., et al. MDM2 induces NF-κB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia. Blood 99 (2002) 3367-3375
    • (2002) Blood , vol.99 , pp. 3367-3375
    • Gu, L.1
  • 76
    • 42549095061 scopus 로고    scopus 로고
    • MDM2 displays differential activities dependent upon the activation status of NFκB
    • Cheney M.D., et al. MDM2 displays differential activities dependent upon the activation status of NFκB. Cancer Biol. Ther. 7 (2008) 38-44
    • (2008) Cancer Biol. Ther. , vol.7 , pp. 38-44
    • Cheney, M.D.1
  • 77
    • 53649093334 scopus 로고    scopus 로고
    • Mdm2 exerts pro-apoptotic activities by antagonizing insulin-like growth factor-I-mediated survival
    • Froment P., et al. Mdm2 exerts pro-apoptotic activities by antagonizing insulin-like growth factor-I-mediated survival. Cell Cycle 7 (2008) 3098-3103
    • (2008) Cell Cycle , vol.7 , pp. 3098-3103
    • Froment, P.1
  • 78
    • 35148837581 scopus 로고    scopus 로고
    • Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway - therapeutic perspectives in cancer
    • Tao Y., et al. Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway - therapeutic perspectives in cancer. Nat. Clin. Pract. Oncol. 4 (2007) 591-602
    • (2007) Nat. Clin. Pract. Oncol. , vol.4 , pp. 591-602
    • Tao, Y.1
  • 79
    • 0037816235 scopus 로고    scopus 로고
    • Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor
    • Girnita L., et al. Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 8247-8252
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 8247-8252
    • Girnita, L.1
  • 80
    • 57049114832 scopus 로고    scopus 로고
    • The genetics of the p53 pathway, apoptosis and cancer therapy
    • Vazquez A., et al. The genetics of the p53 pathway, apoptosis and cancer therapy. Nat. Rev. Drug Discov. 7 (2008) 979-987
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 979-987
    • Vazquez, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.