-
1
-
-
33746382921
-
Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor
-
Yao, X., Parnot, C., Deupi, X., Ratnala, V. R., Swaminath, G., Farrens, D., and Kobilka, B. (2006) Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor. Nat Chem Biol 2, 417–22.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 417-422
-
-
Yao, X.1
Parnot, C.2
Deupi, X.3
Ratnala, V.R.4
Swaminath, G.5
Farrens, D.6
Kobilka, B.7
-
2
-
-
34250376066
-
Structure and conformational changes in the C-terminal domain of the beta2-adrenoceptor
-
Granier, S., Kim, S., Shafer, A. M., Ratnala, V. R., Fung, J. J., Zare, R. N., and Kobilka, B. (2007) Structure and conformational changes in the C-terminal domain of the beta2-adrenoceptor: insights from fluorescence resonance energy transfer studies. J Biol Chem 282, 13895–905.
-
(2007)
Insights from Fluorescence Resonance Energy Transfer Studies. J Biol Chem
, vol.282
, pp. 13895-13905
-
-
Granier, S.1
Kim, S.2
Shafer, A.M.3
Ratnala, V.R.4
Fung, J.J.5
Zare, R.N.6
Kobilka, B.7
-
3
-
-
37549016836
-
Heterotrimeric G protein activation by G-protein-coupled receptors
-
Oldham, W. M., and Hamm, H. E. (2008) Heterotrimeric G protein activation by G-protein-coupled receptors. Nat Rev Mol Cell Biol 9, 60–71.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 60-71
-
-
Oldham, W.M.1
Hamm, H.E.2
-
4
-
-
70349810683
-
Structural evidence for a sequential release mechanism for activation of heterotrimeric G proteins
-
Kapoor, N., Menon, S. T., Chauhan, R., Sachdev, P., and Sakmar, T. P. (2009) Structural evidence for a sequential release mechanism for activation of heterotrimeric G proteins. J Mol Biol 393, 882–97.
-
(2009)
J Mol Biol
, vol.393
, pp. 882-897
-
-
Kapoor, N.1
Menon, S.T.2
Chauhan, R.3
Sachdev, P.4
Sakmar, T.P.5
-
5
-
-
55649085958
-
Collision coupling, crosstalk, and compartmentalization in G-protein coupled receptor systems: Can a single model explain disparate results?
-
Brinkerhoff, C. J., Traynor, J. R., and Linderman, J. J. (2008) Collision coupling, crosstalk, and compartmentalization in G-protein coupled receptor systems: can a single model explain disparate results? J Theor Biol 255, 278–86.
-
(2008)
J Theor Biol
, vol.255
, pp. 278-286
-
-
Brinkerhoff, C.J.1
Traynor, J.R.2
Linderman, J.J.3
-
7
-
-
0019303218
-
Resolution, reconstitution and kinetics of the primary action of a hormone receptor
-
Citri, Y., and Schramm, M. (1980) Resolution, reconstitution and kinetics of the primary action of a hormone receptor. Nature 287, 297–300.
-
(1980)
Nature
, vol.287
, pp. 297-300
-
-
Citri, Y.1
Schramm, M.2
-
8
-
-
33646857233
-
Detecting and imaging protein-protein interactions during G protein-mediated signal transduction in vivo and in situ by using fluorescence-based techniques
-
Hebert, T. E., Gales, C., and Rebois, R. V. (2006) Detecting and imaging protein-protein interactions during G protein-mediated signal transduction in vivo and in situ by using fluorescence-based techniques. Cell Biochem Biophys 45, 85–109.
-
(2006)
Cell Biochem Biophys
, vol.45
, pp. 85-109
-
-
Hebert, T.E.1
Gales, C.2
Rebois, R.V.3
-
9
-
-
39949085589
-
Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors
-
Lohse, M. J., Nikolaev, V. O., Hein, P., Hoffmann, C., Vilardaga, J. P., and Bünemann, M. (2008) Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors. Trends Pharmacol Sci 29, 159–65.
-
(2008)
Trends Pharmacol Sci
, vol.29
, pp. 159-165
-
-
Lohse, M.J.1
Nikolaev, V.O.2
Hein, P.3
Hoffmann, C.4
Vilardaga, J.P.5
Bünemann, M.6
-
10
-
-
57649157684
-
Membrane signalling complexes: Implications for development of functionally selective ligands modulating heptahelical receptor signalling
-
Pineyro, G. (2009) Membrane signalling complexes: implications for development of functionally selective ligands modulating heptahelical receptor signalling. Cell Signal 21, 179–85.
-
(2009)
Cell Signal
, vol.21
, pp. 179-185
-
-
Pineyro, G.1
-
11
-
-
18744376919
-
Real-time monitoring of receptor and G-protein interactions in living cells
-
Galés, C., Rebois, R. V., Hogue, M., Trieu, P., Breit, A., Hébert, T. E., and Bouvier, M. (2005) Real-time monitoring of receptor and G-protein interactions in living cells. Nat Methods 2, 177–84.
-
(2005)
Nat Methods
, vol.2
, pp. 177-184
-
-
Galés, C.1
Rebois, R.V.2
Hogue, M.3
Trieu, P.4
Breit, A.5
Hébert, T.E.6
Bouvier, M.7
-
12
-
-
33746871075
-
Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells
-
Rebois, R. V., Robitaille, M., Galés, C., Dupré, D. J., Baragli, A., Trieu, P., Ethier, N., Bouvier, M., and Hébert, T. E. (2006) Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells. J Cell Sci 119, 2807–18.
-
(2006)
J Cell Sci
, vol.119
, pp. 2807-2818
-
-
Rebois, R.V.1
Robitaille, M.2
Galés, C.3
Dupré, D.J.4
Baragli, A.5
Trieu, P.6
Ethier, N.7
Bouvier, M.8
Hébert, T.E.9
-
13
-
-
47249147029
-
Bioluminescence resonance energy transfer assays reveal ligand-specific conformational changes within preformed signaling complexes containing delta-opioid receptors and heterotrimeric G proteins
-
Audet, N., Galés, C., Archer-Lahlou, E., Vallières, M., Schiller, P. W., Bouvier, M., and Pineyro, G. (2008) Bioluminescence resonance energy transfer assays reveal ligand-specific conformational changes within preformed signaling complexes containing delta-opioid receptors and heterotrimeric G proteins. J Biol Chem 283, 15078–88.
-
(2008)
J Biol Chem
, vol.283
, pp. 15078-15088
-
-
Audet, N.1
Galés, C.2
Archer-Lahlou, E.3
Vallières, M.4
Schiller, P.W.5
Bouvier, M.6
Pineyro, G.7
-
14
-
-
0034724192
-
Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)
-
Angers, S., Salahpour, A., Joly, E., Hilairet, S., Chelsky, D., Dennis, M., and Bouvier, M. (2000) Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). Proc Natl Acad Sci U S A 97, 3684–9.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 3684-3689
-
-
Angers, S.1
Salahpour, A.2
Joly, E.3
Hilairet, S.4
Chelsky, D.5
Dennis, M.6
Bouvier, M.7
-
15
-
-
21344433619
-
Methods to monitor the quaternary structure of G protein-coupled receptors
-
Milligan, G., and Bouvier, M. (2005) Methods to monitor the quaternary structure of G protein-coupled receptors. Febs J 272, 2914–25.
-
(2005)
Febs J
, vol.272
, pp. 2914-2925
-
-
Milligan, G.1
Bouvier, M.2
-
16
-
-
34447645129
-
Resonance energy transfer approaches in molecular pharmacology and beyond
-
Marullo, S., and Bouvier, M. (2007) Resonance energy transfer approaches in molecular pharmacology and beyond. Trends Pharmacol Sci 28, 362–5.
-
(2007)
Trends Pharmacol Sci
, vol.28
, pp. 362-365
-
-
Marullo, S.1
Bouvier, M.2
-
17
-
-
33845923854
-
BRET analysis of GPCR oligomerization: Newer does not mean better
-
author reply 4
-
Bouvier, M., Heveker, N., Jockers, R., Marullo, S., and Milligan, G. (2007) BRET analysis of GPCR oligomerization: newer does not mean better. Nat Methods 4, 3–4; author reply 4.
-
(2007)
Nat Methods
, vol.4
, pp. 3-4
-
-
Bouvier, M.1
Heveker, N.2
Jockers, R.3
Marullo, S.4
Milligan, G.5
-
18
-
-
34547636173
-
Experimental challenge to a ‘rigorous’ BRET analysis of GPCR oligomerization
-
author reply 601
-
Salahpour, A., and Masri, B. (2007) Experimental challenge to a ‘rigorous’ BRET analysis of GPCR oligomerization. Nat Methods 4, 599–600; author reply 601.
-
(2007)
Nat Methods
, vol.4
, pp. 599-600
-
-
Salahpour, A.1
Masri, B.2
-
19
-
-
31444435283
-
The quantification and differentiation of the drug receptor theory, c. 1910–1960
-
Maehle, A. H. (2005) The quantification and differentiation of the drug receptor theory, c. 1910–1960. Ann Sci 62, 479–500.
-
(2005)
Ann Sci
, vol.62
, pp. 479-500
-
-
Maehle, A.H.1
-
20
-
-
30444460582
-
The quantitative analysis of drug-receptor interactions: A short history
-
Colquhoun, D. (2006) The quantitative analysis of drug-receptor interactions: a short history. Trends Pharmacol Sci 27, 149–57.
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 149-157
-
-
Colquhoun, D.1
-
21
-
-
0030993594
-
Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor
-
Roettger, B. F., Ghanekar, D., Rao, R., Toledo, C., Yingling, J., Pinon, D., and Miller, L. J. (1997) Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor. Mol Pharmacol 51, 357–62.
-
(1997)
Mol Pharmacol
, vol.51
, pp. 357-362
-
-
Roettger, B.F.1
Ghanekar, D.2
Rao, R.3
Toledo, C.4
Yingling, J.5
Pinon, D.6
Miller, L.J.7
-
22
-
-
0032545531
-
Serotonin 5-HT2C agonists selectively inhibit morphine-induced dopamine efflux in the nucleus accumbens
-
Willins, D. L., and Meltzer, H. Y. (1998) Serotonin 5-HT2C agonists selectively inhibit morphine-induced dopamine efflux in the nucleus accumbens. Brain Res 781, 291–9.
-
(1998)
Brain Res
, vol.781
, pp. 291-299
-
-
Willins, D.L.1
Meltzer, H.Y.2
-
23
-
-
0141593597
-
Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
-
Azzi, M., Charest, P. G., Angers, S., Rousseau, G., Kohout, T., Bouvier, M., and Piñeyro, G. (2003) Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Proc Natl Acad Sci U S A 100, 11406–11.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 11406-11411
-
-
Azzi, M.1
Charest, P.G.2
Angers, S.3
Rousseau, G.4
Kohout, T.5
Bouvier, M.6
Piñeyro, G.7
-
24
-
-
14844333116
-
Internalization and Src activity regulate the time course of ERK activation by delta opioid receptor ligands
-
Audet, N., Paquin-Gobeil, M., Landry-Paquet, O., Schiller, P. W., and Pineyro, G. (2005) Internalization and Src activity regulate the time course of ERK activation by delta opioid receptor ligands. J Biol Chem 280, 7808–16.
-
(2005)
J Biol Chem
, vol.280
, pp. 7808-7816
-
-
Audet, N.1
Paquin-Gobeil, M.2
Landry-Paquet, O.3
Schiller, P.W.4
Pineyro, G.5
-
25
-
-
33846456218
-
An opioid agonist that does not induce micro-opioid receptor--arrestin interactions or receptor internalization
-
Groer, C. E., Tidgewell, K., Moyer, R. A., Harding, W. W., Rothman, R. B., Prisinzano, T. E., and Bohn, L. M. (2007) An opioid agonist that does not induce micro-opioid receptor--arrestin interactions or receptor internalization. Mol Pharmacol 71, 549–57.
-
(2007)
Mol Pharmacol
, vol.71
, pp. 549-557
-
-
Groer, C.E.1
Tidgewell, K.2
Moyer, R.A.3
Harding, W.W.4
Rothman, R.B.5
Prisinzano, T.E.6
Bohn, L.M.7
-
26
-
-
33845903110
-
Functional selectivity and classical concepts of quantitative pharmacology
-
Urban, J. D., Clarke, W. P., von Zastrow, M., Nichols, D. E., Kobilka, B., Weinstein, H., Javitch, J. A., Roth, B. L., Christopoulos, A., Sexton, P. M., Miller, K. J., Spedding, M., and Mailman, R. B. (2007) Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther 320, 1–13.
-
(2007)
J Pharmacol Exp Ther
, vol.320
, pp. 1-13
-
-
Urban, J.D.1
Clarke, W.P.2
von Zastrow, M.3
Nichols, D.E.4
Kobilka, B.5
Weinstein, H.6
Javitch, J.A.7
Roth, B.L.8
Christopoulos, A.9
Sexton, P.M.10
Miller, K.J.11
Spedding, M.12
Mailman, R.B.13
-
27
-
-
45849112499
-
On the analysis of ligand-directed signaling at G protein-coupled receptors
-
Ehlert, F. J. (2008) On the analysis of ligand-directed signaling at G protein-coupled receptors. Naunyn Schmiedebergs Arch Pharmacol 377, 549–77.
-
(2008)
Naunyn Schmiedebergs Arch Pharmacol
, vol.377
, pp. 549-577
-
-
Ehlert, F.J.1
-
28
-
-
27844519281
-
New concepts in drug discovery: Collateral efficacy and permissive antagonism
-
Kenakin, T. (2005) New concepts in drug discovery: collateral efficacy and permissive antagonism. Nat Rev Drug Discov 4, 919–27.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 919-927
-
-
Kenakin, T.1
-
29
-
-
36348946976
-
Functional selectivity through protean and biased agonism: Who steers the ship?
-
Kenakin, T. (2007) Functional selectivity through protean and biased agonism: who steers the ship? Mol Pharmacol 72, 1393–401.
-
(2007)
Mol Pharmacol
, vol.72
, pp. 1393-1401
-
-
Kenakin, T.1
-
30
-
-
34250637175
-
Bioluminescence resonance energy transfer (BRET) for the real-time detection of protein-protein interactions
-
Pfleger, K. D., Seeber, R. M., and Eidne, K. A. (2006) Bioluminescence resonance energy transfer (BRET) for the real-time detection of protein-protein interactions. Nat Protoc 1, 337–45.
-
(2006)
Nat Protoc
, vol.1
, pp. 337-345
-
-
Pfleger, K.D.1
Seeber, R.M.2
Eidne, K.A.3
-
31
-
-
33748101201
-
Consensus guided mutagenesis of Renilla luciferase yields enhanced stability and light output
-
Loening, A. M., Fenn, T. D., Wu, A. M., and Gambhir, S. S. (2006) Consensus guided mutagenesis of Renilla luciferase yields enhanced stability and light output. Protein Eng Des Sel 19, 391–400.
-
(2006)
Protein Eng Des Sel
, vol.19
, pp. 391-400
-
-
Loening, A.M.1
Fenn, T.D.2
Wu, A.M.3
Gambhir, S.S.4
-
32
-
-
53649086041
-
Demonstration of improvements to the bioluminescence resonance energy transfer (BRET) technology for the monitoring of G protein-coupled receptors in live cells
-
Kocan, M., See, H. B., Seeber, R. M., Eidne, K. A., and Pfleger, K. D. (2008) Demonstration of improvements to the bioluminescence resonance energy transfer (BRET) technology for the monitoring of G protein-coupled receptors in live cells. J Biomol Screen 13, 888–98.
-
(2008)
J Biomol Screen
, vol.13
, pp. 888-898
-
-
Kocan, M.1
See, H.B.2
Seeber, R.M.3
Eidne, K.A.4
Pfleger, K.D.5
|