Structural biology of human metal-dependent histone deacetylases

Handbook of Experimental Pharmacology

Volumn 206, Issue , 2011, Pages 225-240

  Schapira, Matthieu ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Binding pocket; Catalysis; Class IIa HDAC; Electrostatics; HDAC; HDAC4; HDAC7; Hydroxamate; Inhibitors; Metal; Pharmacophore; Selectivity; Structure; Substrate; Trifluoroacetyl lysine

Indexed keywords

CRA 19156; FERROUS ION; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 7; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; MS 344; N HYDROXY 4 [METHYL [(5 PYRIDIN 2 YL 2 THIENYL)SULFONYL]AMINO]BENZAMIDE; TRICHOSTATIN A; UNCLASSIFIED DRUG; VORINOSTAT; ZINC ION;

ARTICLE; BINDING SITE; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; MOLECULAR RECOGNITION; PHARMACOPHORE; PRIORITY JOURNAL; PROTON TRANSPORT;

ACETYLATION; AMINO ACID SEQUENCE; CATALYSIS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; METALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 80054765573     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-21631-2_10     Document Type: Article

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