Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design

ACS Medicinal Chemistry Letters

Volumn 2, Issue 10, 2011, Pages 764-767

  Yuan, Ziyan ^a   Kumar, Eric A ^a   Campbell, Stephen J ^b   Palermo, Nicholas Y ^a   Kizhake, Smitha ^a   Glover, J N Mark ^b   Natarajan, Amarnath ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

BRCT inhibitors and breast cancer; peptide mimics; Protein protein interface

Indexed keywords

BRCA1 PROTEIN; BREAST CANCER GENE 1 CARBOXY TERMINUS PROTEIN; MDC1 PROTEIN; STREPTAVIDIN; TOPBP1 PROTEIN; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DRUG PROTEIN BINDING; HYDROPHOBICITY; IC 50; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

EID: 80054764503     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200147a     Document Type: Article

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