A critical evaluation of clinical decision support for the detection of drugdrug interactions

Expert Opinion on Drug Safety

Volumn 10, Issue 6, 2011, Pages 871-882

  Smithburger, Pamela L ^a   Buckley, Mitchell S ^b   Bejian, Sharon ^c   Burenheide, Katie ^d   Kane Gill, Sandra L ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b BANNER GOOD SAMARITAN MEDICAL CENTER   (United States)

^c INOVA FAIRFAX HOSPITAL FOR CHILDREN   (United States)

^d Stormont Vail Healthcare   (United States)

Author keywords

Clinical decision support software; Computer physician order entry; Drugdrug interactions

Indexed keywords

ALERTNESS; CLINICAL DECISION MAKING; DATA BASE; DECISION SUPPORT SYSTEM; EVALUATION; HUMAN; MEDICAL RESEARCH; PATIENT COMPLIANCE; PATIENT INFORMATION; PATIENT SAFETY; REVIEW; SIGNAL NOISE RATIO;

DECISION SUPPORT SYSTEMS, CLINICAL; DRUG INTERACTIONS; HUMANS; MEDICAL ORDER ENTRY SYSTEMS; MEDICATION ERRORS; REMINDER SYSTEMS; SAFETY;

EID: 80054761341     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1517/14740338.2011.583916     Document Type: Review

References (53)

1. HITECH Funding Opportunities. The office of the national coordinator for health information technology. ashington, DC; 2010. Available from: http://healthit.hhs.gov/portal/server.pt/community/healthit-hhs-gov-hitech-and- funding- opportunities/1310. [Last accessed 5 January 2010]
2. Bates DW. CPOE and clinical decision support in hospitals. Arch Intern Med 2010;70(17):1583-4
3. Metzger J, Welebob E, Bates DW, et al. Mixed results in the safety performance of computerized physician order entry. Health Aff 2010;29(4):655-63
4. Braden BJ, Corritore C, McNess P. Computerized decision support systems: implications for practice. Stud Health Technol Inform 1997;46:300-4 (Pubitemid 128028637)
5. Teich JM, Osheroff JA, Pifer EA, et al. Clinical decision support in electronic prescribing: recommendations and an action plan: report of the joint clinical decision support workgroup. JAMA 2005;12:365-76 (Pubitemid 40922896)
6. Kuperman GJ, Bobb A, Payne TH, et al. Medication-related clinical decision support in computerized provider order entry systems: a review. J Am Med Inform Assoc 2007;14(1):29-40 (Pubitemid 44909484)
7. Bertsche T, Pfaff J, Schiller P, et al. Prevention of adverse drug reactions in intensive care patients by personal intervention based on an electronic clinical decision support system. Intensive Care Med 2010;36:665-72
8. van Roon EN, Flikweert S, le Comte M, et al. Clinical relevance of drug interactions: a structured assessment procedure. Drug Saf 2005;28(12):1131-9 (Pubitemid 41776003)
9. Glassman PA, Simon B, Belperio P, Lanto A. Improving recognition of drug interactions: benefits and barriers to using automated drug alerts. Med Care 2002;40(12):1161-71
10. Payne TH, Nichol WP, Hoey P, Savarino J. Characteristics and override rates of order checks in a practitioner order entry system. Proc AMIA; 2002. p. 602-6
11. Oppenheim MI, Vidal C, Velasco FT, et al. Impact of a computerized alert during physician order entry on medication dosing in patients with renal impairment. Proc AMIA; 2002. p. 577-81
12. Kalmeijer MD, Holtzer W, van Dongen R, Guchelaar H-J. Implementation of a computerized physician order entry system at the Academic Medical Centre in Amsterdam. PharmWorkd Sci 2003;25:88-93 (Pubitemid 36749798)
13. Van der Sijs H, Aarts J, Vulto A, Berg M. Overriding of drug safety alerts in computerized physician order entry. J Am Med Inform Assoc 2006;13(2):138-47 (Pubitemid 43332904)
14. Van der Sijs H, Mulder A, van Gelder T, et al. Drug safety alert generation and overriding in a large Dutch university medical centre. Pharmacoepidemiology and Drug Safety 2009;18:941-7
15. Seidling HM, Storch CH, Bertsche T, et al. Successful strategy to improve the specificity of electronic statin-drug interaction alerts. Eur J Clin pharmacol 2009;65:1149-57
16. Feldstein AC, Smith DH, Parrin N, et al. Reducing warfarin medication interactions: an interrupted time series evaluation. Arch Intern Med 2006;166(9):1009-15
17. Lapane KL, Waring ME, Schneider KL, et al. A mixed method study of merits of e-prescribing drug alerts in primary care. J Gen Intern Med 2008;23(4):442-6 (Pubitemid 351464878)
18. Shah NR, Seger AC, Seger DL, et al. Improving acceptance of computerized prescribing alerts in ambulatory care. J Am Med Inform Assoc 2006;13(1):5-11 (Pubitemid 41828329)
19. Paterno MD, Maviglia SM, Gorman PN, et al. Tiering drug-drug interaction alerts by severity increases compliance rates. J Am Med Inform Assoc 2009;16(1):40-6
20. Smithburger PL, Kane-Gill SL, Seybert AL. Significance of drug-drug interactions in cardiac and cardiothoracic intensive care units. Drug Saf 2010;33(10):879-88
21. Raschke RA, Gollihare B, Wunderlih TA, et al. A computer alert system to prevent injury from adverse drug events: development and evaluation in a community teaching hospital. JAMA 1998;280:1317-20 (Pubitemid 28473717)
22. Classen D. Clinical decision support systems to improve clinical practice and quality of care (editorial). JAMA 1998;280:1360-1 (Pubitemid 28473726)
23. Horn JR, Hansten PD. Prescribers knowledge of drug interactions. Pharmacy Times August 1, 2008. Available from: http://www. pharmacytimes.com/ publications/issue/2008/2008-08/2008-08-8653/
24. Rothschild JM, Lee TH, Bae T, et al. Survey of physicians' experience using a handheld drug reference guide. Converging information, technology and healthcare. Proceedings of the 2000 AMIA Annual Symposium
25. Abarca J, Malone DC, Armstrong EP, et al. Concordance of severity ratings provided in four drug interactions compendia. J Am Pharm Assoc 2004;44-2
26. Institute for Safe Medication Practices. ISMP Medication Safety alert: heed this warning! Don't miss important computer alerts. ISMP 2007;12(3):1-3
27. Anton C, Nightingale PG, Adu D, et al. Improving prescribing using a rule based prescribing system. Qual Saf Health Care 2004;13(3):186-90 (Pubitemid 38797504)
28. Nightingale PG, Adu D, Richards NT, Peters M. Implementation of rules based computerised bedside prescribing and administration: intervention study. BMJ 2000;320:750-3 (Pubitemid 30179422)
29. Abookire SA, Teich JM, Sandige H, et al. Improving allergy alerting in a computerized physician order entry system. Proc AMIA Symposium; 2000. p. 2-6
30. Peterson JF, Kuperman GJ, Shek C, Bates DW. Physician responses to life-threatening drug-drug interaction alerts [abstratct]. J Gen Intern Med 2001;16:212
31. Chertow GM, Lee J, Kuperman GJ, et al. Guided medication dosing for inpatients with renal insufficiency. JAMA 2001;286(22):2839-44 (Pubitemid 33126926)
32. Weingart SN, Toth M, Sands DZ, et al. Physicians' decisions to override computerized drug alerts in primary care. Arch Intern Med 2003;163:2625-31 (Pubitemid 37464421)
33. Hsieh TC, Kuperman GJ, Jaggi T, et al. Characteristics and consequences of drug-allergy alert overrides in a computerized physician order entry system. J Am Med Inform Assoc 2004;11:482-91 (Pubitemid 39421732)
34. Taylor L, Tamblyn R. Reasons for physician non-adherence to electronic drug alerts. Medinfo 2004;11:1101-5
35. Magnus D, Rodgers S, Avery AJ. GPs' views on computerized drug interaction alerts: questionnaire survey. J Clin Pharm Ther 2002;27:377-82 (Pubitemid 35286237)
36. Ashworth M. GPs' views on computerized drug interaction alerts. J Clin Pharm Ther 2002;27:311-12 (Pubitemid 35286227)
37. Overhage JM, Tierney WM, Zhou X-H, McDonald CJ. A randomized trial of corollary orders to prevent errors of omission. J Am Med Inform Assoc 1997;4:364-75 (Pubitemid 127433631)
38. Krall MA, Sittig DF. Subjective assessment of usefulness and appropriate presentation mode of alerts and reminders in the outpatient setting. Proc AMIA Symposium; 2001. p. 334-8
39. Krall MA, Sittig DF. Clinicians' assessment of outpatient electronic medical record alert and reminder usability and usefulness requirements. Proc AMIA Symposium; 2002. p. 400-4
40. Ahearn MD, Kerr SJ. General practitioners' perceptions of the pharmaceutical decision-support tools in their prescribing software. Med J Aust 2003;179:34-7 (Pubitemid 36896191)
41. van der Sijs H, Aarts J, van Gelder T, et al. Turning off frequently overridden drug alerts: limited opportunities for doing it safely. J Am Med Inform Assoc 2008;15:439-48 (Pubitemid 351885159)
42. Tamblyn R, Huang A, Taylor L, et al. A randomized trial of the effectiveness of on-demand versus computer-triggered drug decision support in primary care. J Am Med Inform Assoc 2008;15:430-8 (Pubitemid 351885165)
43. van der Sijs H, Lammers L, ven den Tweel A, et al. Time-dependent drug-drug interaction alerts in care provider order entry: software may inhibit medication error reductions. J Am Med Inform Assoc 2009;16:864-8
44. Strom BL, Schinnar R, Bilker W, et al. Randomized clinical trial of a customized electronic alert requiring an affirmative response compared to a control group receiving a commercial passive CPOE alert: NSAID-wafarin co-prescribing as a test case. J Am Med Inform Assoc 2010;17:411-15
45. Strom BL, Schinnar R, Aberra F, et al. Unintended effects of computerized physician order entry nearly hard-stop alert to prevent a drug interaction: a randomized controlled trial. Arch Intern Med 2010;170:1578-83
46. Glassman PA, Belperio P, Lanto A, et al. The utility of adding retrospective medication profiling to computerized provider order entry in an ambulatory care population. J Am Med Inform Assoc 2007;14:424-31 (Pubitemid 46963041)
47. Hazlet TK, Lee TA, Hansten PD, Horn JR. Performance of community pharmacy drug interaction software. J Am Pharm Assoc 2001;41(2):200-4
48. Abarca J, Colon LR, Wang VS, et al. Evaluation of the Performance of Drug-Drug interaction screening software in community and hospital pharmacies. JMCP 2006;12(5):383-9 (Pubitemid 47400595)
49. Gaikwad R, Sketris I, Shepard M, Duffy J. Evaluation of accuracy of drug interactions triggered by two electronic medical record systems in primary healthcare. Health Informatics J 2007;13:163-77 (Pubitemid 47308346)
50. Smith WD, Hatton RC, Fann AL, et al. Evaluation of drug interaction software to identify alerts for transplant medications. Ann Pharmacother 2005;39:45-50 (Pubitemid 40052377)
51. Smithburger PL, Kane-Gill SL, Benedict NJ, et al. Grading the severity of drug-drug interactions in the intensive care unit: a comparison between clinician assessment and proprietary database severity rankings. Ann Pharmacother 2010;44(11):1718-24
52. Bottiger Y, Laine K, Andersson L, et al. SFINX-a drug-drug interaction database designed for clinical decision support systems. Eur J Clin Pharmacol 2009;65:627-33
53. Kane-Gill SL, Dasta JF, Schneider PJ, Cook CH. Monitoring abnormal laboratory values as antecedents to drug-induced injury. J Trauma 2005;59(6):1457-62