Reducing warfarin medication interactions: An interrupted time series evaluation

Archives of Internal Medicine

Volumn 166, Issue 9, 2006, Pages 1009-1015

  Feldstein, Adrianne C ^a,b   Smith, David H ^a   Perrin, Nancy ^a   Yang, Xiuhai ^a   Simon, Steven R ^c   Krall, Michael ^b   Sittig, Dean F ^a,b   Ditmer, Diane ^b   Platt, Richard ^c   Soumerai, Stephen B ^c  

^a CENTER FOR HEALTH RESEARCH   (United States)

^b Northwest Permanente   (United States)

^c HARVARD PILGRIM HEALTH CARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE; CLINDAMYCIN; CLOTRIMAZOLE; CODEINE; FLUCONAZOLE; FURAZOLIDONE; METRONIDAZOLE; MORPHINE; NITROFURANTOIN; NONSTEROID ANTIINFLAMMATORY AGENT; NYSTATIN; OXYCODONE; PARACETAMOL; PAROMOMYCIN; SULFAMETHOXAZOLE; TRIMETHOPRIM; WARFARIN;

AGED; ARTICLE; BLEEDING; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DRUG EFFICACY; DRUG POTENTIATION; DRUG USE; ELECTRONIC MEDICAL RECORD; FEMALE; HEALTH CARE ORGANIZATION; HUMAN; INTERNATIONAL NORMALIZED RATIO; MALE; PRESCRIPTION; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

EID: 33646416748     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinte.166.9.1009     Document Type: Article

References (26)

1. Greenblatt DJ, von Moltke LL. Interaction of warfarin with drugs, natural substances, and foods. J Clin Pharmacol. 2005;45:127-132.
2. Howard PA, Ellerbeck EF, Engelman KK, Patterson KL. The nature and frequency of potential warfarin drug interactions that increase the risk of bleeding in patients with atrial fibrillation. Pharmacoepidemiol Drug Saf. 2002;11:569-576.
3. Wittkowsky AK, Boccuzzi SJ, Wogen J, Wygant G, Patel P, Hauch O. Frequency of concurrent use of warfarin with potentially interacting drugs. Pharmacotherapy. 2004;24:1668-1674.
4. Bates DW, Teich JM, Lee J, et al. The impact of computerized physician order entry on medication error prevention. J Am Med Inform Assoc. 1999;6:313-321.
5. Thomson MA, Oxman AD, Harvey EL, et al. Outreach visits to improve health professional practice and health care outcomes [Cochrane Library]. Oxford, England: Update Software; 1998:issue 1.
6. Freeborn DK, Pope CR. Promise and Performance in Managed Care: The Prepaid Group Practice Model. Baltimore, Md: Johns Hopkins University Press; 1994.
7. Gillings D, Makuc D, Siegel E. Analysis of interrupted time series mortality trends: an example to evaluate regionalized perinatal care. Am J Public Health. 1981;71:38-46.
8. Smith DH, Perrin N, Feldstein A, et al. Effectiveness of decision support in an electronic medical record on prescribing in the elderly [abstract]. Pharmacoepidemiol Drug Saf. 2005;13(suppl 1):S12.
9. Feldstein A, Simon SR, Schneider J, et al. How to design computerized alerts to safe prescribing practices. Jt Comm J Qual Saf. 2004;30:602-613.
10. Feldstein AC, Smith DH, Robertson NR, et al. Design and implementation of decision support for outpatient prescribing in an electronic medical record: the safety in prescribing study. In: Advances in Patient Safety: From Research to Implementation. Vol 3. Rockville, Md: Agency for Healthcare, Research, and Quality; 2005. AHRQ publication 05-0021-3. Available at: http://www.ahrq.gov/ qual/advances. Accessed February 2006.
11. Hylek EM, Heiman H, Skates SJ, Sheehan MA, Singer DE. Acetaminophen and other risk factors for excessive warfarin anticoagulation. JAMA. 1998;279:657-662.
12. Davison GC, Vogel RS, Coffman SG. Think-aloud approaches to cognitive assessment and the articulated thoughts in simulated situations paradigm. J Consult Clin Psychol. 1997;65:950-958.
13. Soumerai SB, Avorn J. Principles of educational outreach ("academic detailing") to improve clinical decision making. JAMA. 1990;263:549-556.
14. Wagner AK, Soumerai SB, Zhang F, Ross-Degnan D. Segmented regression analysis of interrupted time series studies in medication use research. J Clin Pharm Ther. 2002;27:299-309.
15. Halkin H, Katzir I, Kurman I, Jan J, Malkin BB. Preventing drug interactions by online prescription screening in community pharmacies and medical practices. Clin Pharmacol Ther. 2001;69:260-265.
16. Panneerselvam S, Baglin C, Lefort W, Baglin T. Analysis of risk factors for over-anticoagulation in patients receiving long-term warfarin. Br J Haematol. 1998;103:422-424.
17. van der Meer FJ, Rosendaal FR, Vandenbroucke JP, Briet E. Bleeding complications in oral anticoagulant therapy: an analysis of risk factors. Arch Intern Med. 1993;153:1557-1562.
18. Thijssen HH, Soute BA, Vervoort LM, Claessens JG. Paracetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycle. Thromb Haemost. 2004;92:797-802.
19. Andrews FJ. Retroperitoneal haematoma after paracetamol increased anticoagulation. Emerg Med J. 2002;19:84-85.
20. Gebauer MG, Nyfort-Hansen K, Henschke PJ, Gallus AS. Warfarin and acetaminophen interaction. Pharmacotherapy. 2003;23:109-112.
21. Fattinger K, Frisullo R, Masche U, Braunschweig S, Meier PJ, Roos M. No clinically relevant drug interaction between paracetamol and phenprocoumon based on a pharmacoepidemiological cohort study in medical inpatients. Eur J Clin Pharmacol. 2002;57:863-867.
22. Gadisseur AP, van der Meer FJ, Rosendaal FR. Sustained intake of paracetamol (acetaminophen) during oral anticoagulant therapy with coumarins does not cause clinically important INR changes: a randomized double-blind clinical trial. J Thromb Haemost. 2003;1:714-717.
23. Teich JM, Merchia PR, Schmiz JL, Kuperman GJ, Spurr CD, Bates DW. Effects of computerized physician order entry on prescribing practices. Arch Intern Med. 2000;160:2741-2747.
24. Bates DW, Leape LL, Cullen DJ, et al. Effect of computerized physician order entry and a team intervention on prevention of serious medication errors. JAMA. 1998;280:1311-1316.
25. Hylek EM. Paracetamol (acetaminophen) and warfarin interaction: unraveling the pivotal role of the vitamin K cycle. Thromb Haemost. 2004;92:672-673.
26. Glassman PA, Simon B, Belperio P, Lanto A. Improving recognition of drug interactions: benefits and barriers to using automated drug alerts. Med Care. 2002;40:1161-1171.