SFINX - A drug-drug interaction database designed for clinical decision support systems

European Journal of Clinical Pharmacology

Volumn 65, Issue 6, 2009, Pages 627-633

  Böttiger, Ylva ^e   Laine, Kari ^b,c,d   Andersson, Marine L ^e   Korhonen, Tuomas ^b,c,d   Molin, Björn ^a   Ovesjö, Marie Louise ^e   Tirkkonen, Tuire ^b,c,d   Rane, Anders ^e   Gustafsson, Lars L ^a   Eiermann, Birgit ^a  

^a STOCKHOLM COUNTY COUNCIL   (Sweden)

^b Medbase Ltd   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d TURKU UNIVERSITY HOSPITAL   (Finland)

^e KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Clinical decision support system; Drug interactions; Drug drug interaction database

Indexed keywords

ARTICLE; DATA BASE; DECISION SUPPORT SYSTEM; DRUG INTERACTION;

DATABASE MANAGEMENT SYSTEMS; DECISION SUPPORT SYSTEMS, CLINICAL; DRUG INTERACTIONS;

EID: 68849122305     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-008-0612-5     Document Type: Article

References (35)

1. Lazarou J, Pomeranz BH, Corey PN (1998) Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA 279(15):1200-1205 (Pubitemid 28193431)
2. Juurlink DN, Mamdani M, Kopp A, Laupacis A, Redelmeier DA (2003) Drug-drug interactions among elderly patients hospitalized for drug toxicity. JAMA 289(13):1652-1658 (Pubitemid 37430270)
3. Bjerrum L, Andersen M, Petersen G, Kragstrup J (2003) Exposure to potential drug interactions in primary health care. Scand J Prim Health Care 21(3):153-158 (Pubitemid 37174004)
4. Neuvonen PJ, Niemi M, Backman JT (2006) Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther 80(6):565-581 (Pubitemid 44908269)
5. Pai MP, Graci DM, Amsden GW (2000) Macrolide drug interactions: an update. Ann Pharmacother 34(4):495-513 (Pubitemid 30193784)
6. Mitchell PB (1997) Drug interactions of clinical significance with selective serotonin reuptake inhibitors. Drug Saf 17(6):390-406
7. Shear N, Drake L, Gupta AK, Lambert J, Yaniv R (2000) The implications and management of drug interactions with itraconazole, fluconazole and terbinafine. Dermatology 201(3):196-203
8. Hesse LM von Moltke LL, Greenblatt DJ (2003) Clinically important drug interactions with zopiclone, zolpidem and zaleplon. CNS Drugs 17(7):513-532 (Pubitemid 36693705)
9. US Food and Drug Administration (2006) Guidance for industry: drug interaction studies: study design, data analysis, and implications for dosing and labeling. http://www.fda.gov/cder/guidance/6695dft.pdf. Accessed 2008-10-09
10. US Food and Drug Administration (1999) Guidance for industry: in vivo metabolism/drug interactions: study design, data analysis and recommendation for dosing and labeling. http://www.fda.gov/Cder/guidance/2635fnl.pdf. Accessed 2008-10-09
11. EMEA: CPMP/ICH/291/95 (1998) Note for guidance on general considerations for clinical trials. http://www.emea.europa.eu/pdfs/human/ich/029195en.pdf. Accessed 2008-10-09
12. Sindrup SH, Brosen K, Bjerring P, Arendt-Nielsen L, Larsen U, Angelo HR et al (1990) Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine. Clin Pharmacol Ther 48(6):686-693
13. Sindrup SH, Arendt-Nielsen L, Brosen K, Bjerring P, Angelo HR, Eriksen B et al (1992) The effect of quinidine on the analgesic effect of codeine. Eur J Clin Pharmacol 42(6):587-591
14. Tirkkonen T, Laine K (2004) Drug interactions with potential to preventing prodrug activation as a common source of irrational prescribing in hospital inpatients. Clin Pharmacol Ther 76(6):639-647 (Pubitemid 39601553)
15. Garg AX, Adhikari NK, McDonald H, Rosas-Arellano MP, Deveraux PJ, Beyene J et al (2005) Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: a systematic review. JAMA 293(10):1223-1238 (Pubitemid 40327908)
16. van der Sijs H, Aarts J, Vulto A, Berg M (2006) Overriding of drug alerts in computerized physician order entry. J AM Med Inform Assoc 13(2):138-147 (Pubitemid 43332904)
17. Bergk V, Haefeli WE, Gasse C, Brenner H, Martin-Facklam M (2005) Information deficits in the summary of product characteristics preclude an optmial management of drug interactions: a comparison with evidence from the literature. Eur J Clin Pharmacol 61(5-6):327-335 (Pubitemid 41569305)
18. Wolters Kluwer (2008) Hansten and Horn's drug interactions analysis and management. http://www.factsandcomparisons.com. Accessed 2008-10-09
19. Pharmaceutical Press (2008) Stockley 's drug interactions online version. http://www.medicinescomplete.com. Accessed 2008-10-09
20. Wolter Kluwers (2008) Drugline. http://www.ovid.com/site/catalog/ Database/2816.jsp. Accessed 2008-10-09
21. Thomson (2008)DRUGDEX, system provided by MICROMEDEX. http://www.thomsonhc.com/hcs/librarian/PFPUI/i2UCSoAjEX3J.Accessed 2008-10-09
22. NCBI (2008) Medline. http://www.ncbi.nlm.nih.gov/sites/entrez. Accessed 2008-10-09
23. Elsevier (2007) Embase. http://www.embase.com. Accessed 2008-10-09
24. LIF (2008) Swedish PDR and SPC. http://www.fass.se. Accessed 2008-10-09
25. Terveys (2008) Pharmaca fennica. http://www.terveysportti.fi. Accessed 2008-10-09
26. EMEA (2008) The European public assessment reports (EPARs). http://www.emea.europa.eu/index/indexh1.htm. Accessed 2008-10-09
27. Sjöqvist F (1997) A new classification system for drug interactions. Eur J Clin Pharmacol 52 (Suppl):327a
28. Liaw ST, Schattner P (2003) Electronic decision support in general practice. What's the hold up? Aust Fam Physician 3211:941-944
29. Sjöborg B, Bäckström T, Arvidsson LB, Andersen-Karlsson E, Blomberg LB, Eiermann B et al (2007) Design and implementation of a point-of-care computerized system for drug therapy in Stockholm metropolitan health region-bridging the gap between knowledge and practice. Int J Med Info 76(7):497-506 (Pubitemid 46702801)
30. Eliasson M, Bastholm P, Forsberg P, Henriksson K, Jacobson L et al (2006) Janus computerised prescribing system provides pharmacological knowledge at point of care - design, development and proof of concept. Eur J Clin Pharmacol 62(4):251-258
31. Ahearn M, Kerr SJ (2003) General practitioners' perceptions of the pharmaceutical decision-support tools in their prescribing software. Med J Aust 179(1):34-37 (Pubitemid 36896191)
32. Heikkilä T, Lekander T, Raunio H (2006) Use of an online surveillance system for screening drug interactions in prescriptions in community pharmacies. Eur J Clin Pharmacol 62(8):661-665 (Pubitemid 44127996)
33. Grönroos PE, Irjala KM, Huupponen RK, Scheinin H, Forsstrom J, Forsström JJ (1997) A medication database - a tool for detecting drug interactions in hospital. Eur J Clin Pharmacol 53(1):13-17
34. Grizzle AJ, Mahmood MH, Ko Y, Murphy JE, Armstrong EP, Skrepnek GH (2007) Reasons provided by prescribers when overriding drug-drug interaction alerts. Am J Manag Care 13(10):573-578
35. Thompson D, Oster G (1996) Use of terfenadine and contraindicated drugs. JAMA 275(17):1339-1341 (Pubitemid 26131511)