Prevention of adverse drug reactions in intensive care patients by personal intervention based on an electronic clinical decision support system

Intensive Care Medicine

Volumn 36, Issue 4, 2010, Pages 665-672

  Bertsche, Thilo ^a   Pfaff, Johannes ^a   Schiller, Petra ^a   Kaltschmidt, Jens ^a   Pruszydlo, Markus G ^a   Stremmel, Wolfgang ^a   Walter Sack, Ingeborg ^a   Haefeli, Walter E ^a   Encke, Jens ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Computer assisted drug therapy; Drug information services; Drug interactions; Intensive care; Medication errors; Prescriptions drug

Indexed keywords

DRUG;

ADULT; ARTICLE; ARTIFICIAL VENTILATION; BLEEDING DISORDER; COHORT ANALYSIS; CONTROLLED STUDY; DECISION SUPPORT SYSTEM; DRUG INFORMATION; DRUG SURVEILLANCE PROGRAM; DRUG WITHDRAWAL; FEMALE; GLOMERULUS FILTRATION RATE; HEART ARRHYTHMIA; HIGH RISK PATIENT; HUMAN; HYPERTENSION; HYPOKALEMIA; HYPOTENSION; INCIDENCE; INTENSIVE CARE UNIT; KIDNEY FUNCTION; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; MYOPATHY; POLYPHARMACY; PRESCRIPTION; PROSPECTIVE STUDY; QT PROLONGATION; RHABDOMYOLYSIS; RISK MANAGEMENT; RISK REDUCTION; SEROTONIN SYNDROME; SIDE EFFECT; UNIVERSITY HOSPITAL;

ADVERSE DRUG REACTION REPORTING SYSTEMS; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; DECISION SUPPORT SYSTEMS, CLINICAL; DRUG INTERACTIONS; DRUG TOXICITY; FEMALE; HOSPITALS, UNIVERSITY; HUMANS; INTENSIVE CARE; MALE; MIDDLE AGED; POLYPHARMACY; PROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC;

EID: 77951207613     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-010-1778-8     Document Type: Article

References (32)

1. DW Bates N Spell DJ Cullen E Burdick N Laird LA Petersen SD Small BJ Sweitzer LL Leape 1997 The costs of adverse drug events in hospitalized patients. Adverse Drug Events Prevention Study Group JAMA 277 307 311 10.1001/jama.277.4.307 1:STN:280:DyaK2s7lsF2ruw%3D%3D 9002493
2. DC Classen SL Pestotnik RS Evans JF Lloyd JP Burke 1997 Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality JAMA 277 301 306 10.1001/jama.277.4.301 1:STN:280:DyaK2s7lsF2rug%3D%3D 9002492
3. S Schneeweiss J Hasford M Gottler A Hoffmann AK Riethling J Avorn 2002 Admissions caused by adverse drug events to internal medicine and emergency departments in hospitals: a longitudinal population-based study Eur J Clin Pharmacol 58 285 291 10.1007/s00228-002-0467-0 12136375 (Pubitemid 34827858)
4. DC Classen SL Pestotnik RS Evans JP Burke 1991 Computerized surveillance of adverse drug events in hospital patients JAMA 266 2847 2851 10.1001/jama.266.20.2847 1:STN:280:DyaK38%2Fks1Kisw%3D%3D 1942452
5. GI Kohler SM Bode-Boeger R Busse M Hoopmann T Welte RH Boger 2000 Drug-drug interactions in medical patients: effects of in-hospital treatment and relation to multiple drug use Int J Clin Pharmacol Ther 38 504 513 1:STN:280:DC%2BD3MzgsVKisw%3D%3D 11097142
6. Zhang M, Holmann CD, Price SD, Sanflilippo FM, Preen DB, Bulsara MK (2009) Comorbidity and repeated admission to hospital for adverse drug reactions in older adults: retrospective cohort study. BMJ. doi: 10.1136/bmj.a2752
7. R Linnarsson 1993 Drug interactions in primary health care. A retrospective database study and its implications for the design of a computerized decision support system Scand J Prim Health Care 11 181 186 10.3109/02813439308994827 1:STN:280:DyaK2c%2FpvVShtg%3D%3D 8272649
8. F Davidsen T Haghfelt LF Gram K Brosen 1988 Adverse drug reactions and drug non-compliance as primary causes of admission to a cardiology department Eur J Clin Pharmacol 34 83 86 10.1007/BF01061423 1:STN:280:DyaL1c7ps1aiug%3D%3D 3360053
9. T Mjörndal MD Boman S Hägg M Bäckström BE Wiholm A Wahlin R Dahlqvist 2002 Adverse drug reactions as a cause for admissions to a department of internal medicine Pharmacoepidemiol Drug Saf 11 65 72 10.1002/pds.667 11998554 (Pubitemid 34269600)
10. FE May RB Stewart LE Cluff 1977 Drug interactions and multiple drug administration Clin Pharmacol Ther 22 322 328 1:STN:280:DyaE2s3ksV2jtA%3D%3D 891098
11. B Janchawee W Wongpoowarak T Owatranporn V Chongsuvivatwong 2005 Pharmacoepidemiologic study of potential drug interactions in outpatients of a university hospital in Thailand J Clin Pharm Ther 30 13 20 10.1111/j.1365-2710. 2004.00598.x 1:STN:280:DC%2BD2M%2FjtlWntw%3D%3D 15659000 (Pubitemid 41602088)
12. DJ Cullen BJ Sweitzer DW Bates E Burdick A Edmondson LL Leape 1997 Preventable adverse drug events in hospitalized patients: a comparative study of intensive care and general care units Crit Care Med 25 1289 1297 10.1097/00003246-199708000-00014 1:STN:280:DyaK2svhtFyhtQ%3D%3D 9267940 (Pubitemid 27347291)
13. YF Chen AJ Avery KE Neil C Johnson ME Dewey IH Stockley 2005 Incidence and possible causes of prescribing potentially hazardous/contraindicated drug combinations in general practice Drug Saf 28 67 80 10.2165/00002018-200528010- 00005 15649106
14. A Bobb K Gleason M Husch J Feinglass PR Yarnold GA Noskin 2004 The epidemiology of prescribing errors: the potential impact of computerized prescriber order entry Arch Intern Med 164 785 792 10.1001/archinte.164.7.785 15078649 (Pubitemid 38478702)
15. DW Bates JM Teich J Lee D Seger GJ Kuperman N Ma'Luf D Boyle L Leape 1999 The impact of computerized physician order entry on medication error prevention J Am Med Inform Assoc 6 313 321 1:STN:280:DyaK1MzlsV2mug%3D%3D 10428004
16. R Shulman M Singer J Goldstone G Bellingan 2005 Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit Crit Care 9 R516 R521 10.1186/cc3793 16277713
17. P Bedouch B Allenet A Grass J Labarère E Brudieu JL Bosson J Calop 2009 Drug-related problems in medical wards with a computerized physician order entry system J Clin Pharm Ther 34 187 195 10.1111/j.1365-2710.2008.00990.x 1:CAS:528:DC%2BD1MXksF2htL8%3D 19250139
18. JR Nebeker JM Hoffman CR Weir CL Bennett JF Hurdle 2005 High rates of adverse drug events in a highly computerized hospital Arch Intern Med 165 1111 1116 10.1001/archinte.165.10.1111 15911723 (Pubitemid 40720734)
19. R Koppel JP Metlay A Cohen B Abaluck AR Localio SE Kimmel BL Strom 2005 Role of computerized physician order entry systems in facilitating medication errors JAMA 293 1197 1203 10.1001/jama.293.10.1197 1:CAS:528: DC%2BD2MXit1WksbY%3D 15755942 (Pubitemid 40327905)
20. YY Han JA Carcillo ST Venkataraman RS Clark RS Watson TC Nguyen H Bayir RA Orr 2005 Unexpected increased mortality after implementation of a commercially sold computerized physician order entry system Pediatrics 116 1506 1512 10.1542/peds.2005-1287 16322178 (Pubitemid 46056501)
21. H Pirnejad Z Niazkhani H van der Sijs M Berg RA Bal 2009 Evaluation of the impact of a CPOE system on nurse-physician communication: a mixed method study Methods Inf Med 15 48
22. NM LaPointe JG Jollis 2003 Medication errors in hospitalized cardiovascular patients Arch Intern Med 163 1461 1466 10.1001/archinte.163.12. 1461 12824096 (Pubitemid 36758919)
23. LL Leape DJ Cullen MD Clapp E Burdick HJ Demonaco JI Erickson DW Bates 1999 Pharmacist participation on physician rounds and adverse drug events in the intensive care unit JAMA 282 267 270 10.1001/jama.282.3.267 1:STN:280:DyaK1MzkvFymuw%3D%3D 10422996 (Pubitemid 29343170)
24. CA Bond CL Raehl T Franke 2001 Interrelationships among mortality rates, drug costs, total cost of care, and length of stay in United States hospitals: summary and recommendations for clinical pharmacy services and staffing Pharmacotherapy 21 129 141 10.1592/phco.21.2.129.34105 1:STN:280: DC%2BD3M3jt1ylsw%3D%3D 11213848 (Pubitemid 32120146)
25. U Gillespie A Alassaad D Henrohn H Garmo M Hammarlund-Udenaes H Toss A Kettis-Lindblad H Melhus C Mörlin 2009 A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: a randomized controlled trial Arch Intern Med 169 894 900 10.1001/archinternmed.2009.71 19433702
26. L Schwake I Wollenschläger W Stremmel J Encke 2009 Adverse drug reactions and deliberate self-poisoning as cause of admission to the intensive care unit: a 1-year prospective observational cohort study Intensive Care Med 35 266 274 10.1007/s00134-008-1250-1 18696050
27. AX Garg NK Adhikari H McDonald MP Rosas-Arellano PJ Devereaux J Beyene J Sam RB Haynes 2005 Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: a systematic review JAMA 293 1223 1238 10.1001/jama.293.10.1223 1:CAS:528:DC%2BD2MXit1WktLY%3D 15755945 (Pubitemid 40327908)
28. RS Evans SL Pestotnik DC Classen TP Clemmer LK Weaver JF Orme Jr JF Lloyd JP Burke 1998 A computer-assisted management program for antibiotics and other antiinfective agents N Engl J Med 338 232 238 10.1056/NEJM199801223380406 1:STN:280:DyaK1c%2FosVehtg%3D%3D 9435330 (Pubitemid 28047578)
29. A Rivkin 2007 Admissions to a medical intensive care unit related to adverse drug reactions Am J Health Syst Pharm 64 1840 1843 10.2146/ajhp060641 17724366 (Pubitemid 350202217)
30. HC Bazett 1920 An analysis of the time-relations of electrocardiograms Heart 7 353 370
31. AS Levey JP Bosch JB Lewis T Greene N Rogers D Roth 1999 A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group Ann Intern Med 130 461 470 1:CAS:528:DyaK1MXitFChs7k%3D 10075613
32. AS Levey J Coresh T Greene J Marsh LA Stevens JW Kusek F Van Lente Chronic Kidney Disease Epidemiology Collaboration 2007 Expressing the modification of diet in renal disease study equation for estimating glomerular filtration rate with standardized serum creatinine values Clin Chem 53 766 772 10.1373/clinchem.2006.077180 1:CAS:528:DC%2BD2sXksFWhurs%3D 17332152 (Pubitemid 46580250)