Gamete membrane microdomains and their associated molecules in fertilization signaling

Molecular Reproduction and Development

Volumn 78, Issue 10-11, 2011, Pages 814-830

  Hasan, A K M Mahbub ^a   Fukami, Yasuo ^b   Sato, Ken ichi ^a  

^a KYOTO SANGYO UNIVERSITY   (Japan)

^b KOBE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CATHEPSIN B; DIPEPTIDYL CARBOXYPEPTIDASE; FILIPIN; GANGLIOSIDE GM1; GLYCOLIPID; GLYCOPROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; METHYL BETA CYCLODEXTRIN; PROTEIN TYROSINE KINASE; TETRASPANIN; UROPLAKIN;

ALGA; ARTIFICIAL INSEMINATION; B LYMPHOCYTE; BINDING SITE; CALCIUM CELL LEVEL; CELL DEATH; CELL DIVISION; CELL FUNCTION; CELL INTERACTION; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL SURFACE; CELL TRANSPORT; CYTOPLASM; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; FEMALE GENITAL SYSTEM; FERTILIZATION; FLAGELLUM; GAMETE; IN VITRO STUDY; LIPID COMPOSITION; MOLECULAR INTERACTION; NEWBORN; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REPRODUCTION; REVIEW; SIGNAL TRANSDUCTION; SPERM; SPERMATOZOON CAPACITATION; T LYMPHOCYTE; XENOPUS LAEVIS; ZONA PELLUCIDA; ZYGOTE;

ANIMALS; FEMALE; FERTILIZATION; GERM CELLS; MALE; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; OVUM; SIGNAL TRANSDUCTION; SPERM-OVUM INTERACTIONS; SPERMATOZOA;

ALGAE; ANIMALIA; XENOPUS LAEVIS;

EID: 80054761331     PISSN: 1040452X     EISSN: 10982795     Source Type: Journal    
DOI: 10.1002/mrd.21336     Document Type: Review

References (214)

1. Abassi YA, Foltz KR. 1994. Tyrosine phosphorylation of the egg receptor for sperm at fertilization. Dev Biol 164: 430-443.
2. Abassi YA, Carroll DJ, Giusti AF, Belton RJ, Jr., Foltz KR. 2000. Evidence that Src-type tyrosine kinase activity is necessary for initiation of calcium release at fertilization in sea urchin eggs. Dev Biol 218: 206-219.
3. Abram CL, Courtneidge SA. 2000. Src family tyrosine kinases and growth factor signaling. Exp Cell Res 254: 1-13.
4. Ackermann F, Zitranski N, Heydecke D, Wilhelm B, Gudermann T, Boekhoff I. 2008. The multi-PDZ domain protein MUPP1 as a lipid raft-associated scaffolding protein controlling the acrosome reaction in mammalian spermatozoa. J Cell Physiol 214: 757-768.
5. Adachi W, Okubo K, Kinoshita S. 2000. Human uroplakin Ib in ocular surface epithelium. Invest Ophthalmol Vis Sci 41: 2900-2905.
6. Anderson RG. 1998. The caveolae membrane system. Annu Rev Biochem 67: 199-225.
7. Aoto M, Sato K, Takeba S, Horiuchi Y, Iwasaki T, Tokmakov AA, Fukami Y. 1999. A 58-kDa Shc protein is present in Xenopus eggs and is phosphorylated on tyrosine residues upon egg activation. Biochem Biophys Res Commun 258: 265-270.
8. Asano A, Selvaraj V, Buttke DE, Nelson JL, Green KM, Evans JE, Travis AJ. 2009. Biochemical characterization of membrane fractions in murine sperm: Identification of three distinct sub-types of membrane rafts. J Cell Physiol 218: 537-548.
9. Asano A, Nelson JL, Zhang S, Travis AJ. 2010. Characterization of the proteomes associating with three distinct membrane raft sub-types in murine sperm. Proteomics 10: 3494-3505.
10. Belton RJ, Jr., Adams NL, Foltz KR. 2001. Isolation and characterization of sea urchin egg lipid rafts and their possible function during fertilization. Mol Reprod Dev 59: 294-305.
11. Ben-Yosef D, Talmor A, Shwartz L, Granot Y, Shalgi R. 1998. Tyrosyl-phosphorylated proteins are involved in regulation of meiosis in the rat egg. Mol Reprod Dev 49: 176-185.
12. Botto L, Bernabo N, Palestini P, Barboni B. 2010. Bicarbonate induces membrane reorganization and CBR1 and TRPV1 endocannabinoid receptor migration in lipid microdomains in capacitating boar spermatozoa. J Membr Biol 238: 33-41.
13. Bou Khalil M, Chakrabandhu K, Xu H, Weerachatyanukul W, Buhr M, Berger T, Carmona E, Vuong N, Kumarathasan P, Wong PT, Carrier D, Tanphaichitr N. 2006. Sperm capacitation induces an increase in lipid rafts having zona pellucida binding ability and containing sulfogalactosylglycerolipid. Dev Biol 290: 220-235.
14. Brisson A, Wade RH. 1983. Three-dimensional structure of luminal plasma membrane protein from urinary bladder. J Mol Biol 166: 21-36.
15. Brown DA. 2001. Seeing is believing: Visualization of rafts in model membranes. Proc Natl Acad Sci USA 98: 10517-10518.
16. Brown DA. 2006. Lipid rafts, detergent-resistant membranes, and raft targeting signals. Physiology (Bethesda) 21: 430-439.
17. Brown MT, Cooper JA. 1996. Regulation, substrates and functions of src. Biochim Biophys Acta 1287: 121-149.
18. Brown DA, London E. 1997. Structure of detergent-resistant membrane domains: Does phase separation occur in biological membranes? Biochem Biophys Res Commun 240: 1-7.
19. Brown DA, London E. 1998. Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol 14: 111-136.
20. Brown DA, London E. 2000. Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J Biol Chem 275: 17221-17224.
21. Brown DA, Rose JK. 1992. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68: 533-544.
22. Buschiazzo J, Bonini IC, Alonso TS. 2008. Inhibition of Bufo arenarum oocyte maturation induced by cholesterol depletion by methyl-beta-cyclodextrin. Role of low-density caveolae-like membranes. Biochim Biophys Acta 1778: 1398-1406.
23. Carroll DJ, Ramarao CS, Mehlmann LM, Roche S, Terasaki M, Jaffe LA. 1997. Calcium release at fertilization in starfish eggs is mediated by phospholipase Cgamma. J Cell Biol 138: 1303-1311.
24. Carroll DJ, Albay DT, Terasaki M, Jaffe LA, Foltz KR. 1999. Identification of PLCgamma-dependent and -independent events during fertilization of sea urchin eggs. Dev Biol 206: 232-247.
25. Charrin S, Manie S, Billard M, Ashman L, Gerlier D, Boucheix C, Rubinstein E. 2003a. Multiple levels of interactions within the tetraspanin web. Biochem Biophys Res Commun 304: 107-112.
26. Charrin S, Manie S, Thiele C, Billard M, Gerlier D, Boucheix C, Rubinstein E. 2003b. A physical and functional link between cholesterol and tetraspanins. Eur J Immunol 33: 2479-2489.
27. Ciapa B, Epel D. 1991. A rapid change in phosphorylation on tyrosine accompanies fertilization of sea urchin eggs. FEBS Lett 295: 167-170.
28. Comiskey M, Warner CM. 2007. Spatio-temporal localization of membrane lipid rafts in mouse oocytes and cleaving preimplantation embryos. Dev Biol 303: 727-739.
29. Companyo M, Iborra A, Villaverde J, Martinez P, Morros A. 2007. Membrane fluidity changes in goat sperm induced by cholesterol depletion using beta-cyclodextrin. Biochim Biophys Acta 1768: 2246-2255.
30. Cormier EG, Tsamis F, Kajumo F, Durso RJ, Gardner JP, Dragic T. 2004. CD81 is an entry coreceptor for hepatitis C virus. Proc Natl Acad Sci USA 101: 7270-7274.
31. Cross NL. 2004. Reorganization of lipid rafts during capacitation of human sperm. Biol Reprod 71: 1367-1373.
32. Dasgupta JD, Garbers DL. 1983. Tyrosine protein kinase activity during embryogenesis. J Biol Chem 258: 6174-6178.
33. Deng FM, Liang FX, Tu L, Resing KA, Hu P, Supino M, Hu CC, Zhou G, Ding M, Kreibich G, Sun TT. 2002. Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly. J Cell Biol 159: 685-694.
34. Duncan MJ, Li G, Shin JS, Carson JL, Abraham SN. 2004. Bacterial penetration of bladder epithelium through lipid rafts. J Biol Chem 279: 18944-18951.
35. Espenel C, Margeat E, Dosset P, Arduise C, Le Grimellec C, Royer CA, Boucheix C, Rubinstein E, Milhiet PE. 2008. Single-molecule analysis of CD9 dynamics and partitioning reveals multiple modes of interaction in the tetraspanin web. J Cell Biol 182: 765-776.
36. Evans JP, Florman HM. 2002. The state of the union: The cell biology of fertilization. Nat Cell Biol 4: s57-s63.
37. Ferrell JE, Jr., Wu M, Gerhart JC, Martin GS. 1991. Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs. Mol Cell Biol 11: 1965-1971.
38. Fishman PH. 1982. Role of membrane gangliosides in the binding and action of bacterial toxins. J Membr Biol 69: 85-97.
39. Flesch FM, Brouwers JF, Nievelstein PF, Verkleij AJ, van Golde LM, Colenbrander B, Gadella BM. 2001. Bicarbonate stimulated phospholipid scrambling induces cholesterol redistribution and enables cholesterol depletion in the sperm plasma membrane. J Cell Sci 114: 3543-3555.
40. Garcia-Espana A, Chung PJ, Zhao X, Lee A, Pellicer A, Yu J, Sun TT, Desalle R. 2006. Origin of the tetraspanin uroplakins and their co-evolution with associated proteins: Implications for uroplakin structure and function. Mol Phylogenet Evol 41: 355-367.
41. Giusti AF, Carroll DJ, Abassi YA, Foltz KR. 1999a. Evidence that a starfish egg Src family tyrosine kinase associates with PLC-gamma1 SH2 domains at fertilization. Dev Biol 208: 189-199.
42. Giusti AF, Carroll DJ, Abassi YA, Terasaki M, Foltz KR, Jaffe LA. 1999b. Requirement of a Src family kinase for initiating calcium release at fertilization in starfish eggs. J Biol Chem 274: 29318-29322.
43. Giusti AF, Xu W, Hinkle B, Terasaki M, Jaffe LA. 2000. Evidence that fertilization activates starfish eggs by sequential activation of a Src-like kinase and phospholipase cgamma. J Biol Chem 275: 16788-16794.
44. Giusti AF, O'Neill FJ, Yamasu K, Foltz KR, Jaffe LA. 2003. Function of a sea urchin egg Src family kinase in initiating Ca2+ release at fertilization. Dev Biol 256: 367-378.
45. Glahn D, Mark SD, Behr RK, Nuccitelli R. 1999. Tyrosine kinase inhibitors block sperm-induced egg activation in Xenopus laevis Dev Biol 205: 171-180.
46. Haley SA, Wessel GM. 2004. Proteolytic cleavage of the cell surface protein p160 is required for detachment of the fertilization envelope in the sea urchin. Dev Biol 272: 191-202.
47. Harada Y, Sawada H. 2008. Allorecognition mechanisms during ascidian fertilization. Int J Dev Biol 52: 637-645.
48. Harada Y, Takagaki Y, Sunagawa M, Saito T, Yamada L, Taniguchi H, Shoguchi E, Sawada H. 2008. Mechanism of self-sterility in a hermaphroditic chordate. Science 320: 548-550.
49. He HT, Marguet D. 2010. Detecting nanodomains in living cell membrane by fluorescence correlation spectroscopy. Annu Rev Phys Chem 62: 417-436.
50. Heerklotz H. 2002. Triton promotes domain formation in lipid raft mixtures. Biophys J 83: 2693-2701.
51. Hemler ME. 2003. Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. Annu Rev Cell Dev Biol 19: 397-422.
52. Hemler ME. 2005. Tetraspanin functions and associated microdomains. Nat Rev Mol Cell Biol 6: 801-811.
53. Hicks RM, Ketterer B. 1969. Hexagonal lattice of subunits in the thick luminal membrane of the rat urinary bladder. Nature 224: 1304-1305.
54. Hicks RM, Ketterer B. 1970. Isolation of the plasma membrane of the luminal surface of rat bladder epithelium, and the occurrence of a hexagonal lattice of subunits both in negatively stained whole mounts and in sectioned membranes. J Cell Biol 45: 542-553.
55. Hicks RM, Ketterer B, Warren RC. 1974. The ultrastructure and chemistry of the luminal plasma membrane of the mammalian urinary bladder: A structure with low permeability to water and ions. Philos Trans R Soc Lond B Biol Sci 268: 23-38.
56. Honda A, Yamagata K, Sugiura S, Watanabe K, Baba T. 2002. A mouse serine protease TESP5 is selectively included into lipid rafts of sperm membrane presumably as a glycosylphosphatidylinositol-anchored protein. J Biol Chem 277: 16976-16984.
57. Hooper NM. 1999. Detergent-insoluble glycosphingolipid/cholesterol-rich membrane domains, lipid rafts and caveolae (review). Mol Membr Biol 16: 145-156.
58. Hu P, Deng FM, Liang FX, Hu CM, Auerbach AB, Shapiro E, Wu XR, Kachar B, Sun TT. 2000. Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux. J Cell Biol 151: 961-972.
59. Hu CC, Liang FX, Zhou G, Tu L, Tang CH, Zhou J, Kreibich G, Sun TT. 2005. Assembly of urothelial plaques: Tetraspanin function in membrane protein trafficking. Mol Biol Cell 16: 3937-3950.
60. Hunter T. 2009. Tyrosine phosphorylation: Thirty years and counting. Curr Opin Cell Biol 21: 140-146.
61. Inoue N, Ikawa M, Isotani A, Okabe M. 2005. The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature 434: 234-238.
62. Inoue N, Ikawa M, Okabe M. 2010. The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion. Asian J Androl 13: 81-87.
63. Ishitsuka R, Sato SB, Kobayashi T. 2005. Imaging lipid rafts. J Biochem 137: 249-254.
64. Iwasaki T, Koretomo Y, Fukuda T, Paronetto MP, Sette C, Fukami Y, Sato K. 2008. Expression, phosphorylation, and mRNA-binding of heterogeneous nuclear ribonucleoprotein K in Xenopus oocytes, eggs, and early embryos. Dev Growth Differ 50: 23-40.
65. Janes PW, Ley SC, Magee AI. 1999. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J Cell Biol 147: 447-461.
66. Jenkins D, Woolf AS. 2007. Uroplakins: New molecular players in the biology of urinary tract malformations. Kidney Int 71: 195-200.
67. Jones R, Howes E, Dunne PD, James P, Bruckbauer A, Klenerman D. 2010. Tracking diffusion of GM1 gangliosides and zona pellucida binding molecules in sperm plasma membranes following cholesterol efflux. Dev Biol 339: 398-406.
68. Jove R, Hanafusa H. 1987. Cell transformation by the viral src oncogene. Annu Rev Cell Biol 3: 31-56.
69. Kachar B, Liang F, Lins U, Ding M, Wu XR, Stoffler D, Aebi U, Sun TT. 1999. Three-dimensional analysis of the 16nm urothelial plaque particle: Luminal surface exposure, preferential head-to-head interaction, and hinge formation. J Mol Biol 285: 595-608.
70. Kaji K, Oda S, Shikano T, Ohnuki T, Uematsu Y, Sakagami J, Tada N, Miyazaki S, Kudo A. 2000. The gamete fusion process is defective in eggs of Cd9-deficient mice. Nat Genet 24: 279-282.
71. Kalma Y, Granot I, Gnainsky Y, Or Y, Czernobilsky B, Dekel N, Barash A. 2009. Endometrial biopsy-induced gene modulation: First evidence for the expression of bladder-transmembranal uroplakin Ib in human endometrium. Fertil Steril 91: 1042-1049, 1049 e1041-e1049.
72. Kamei N, Glabe CG. 2003. The species-specific egg receptor for sea urchin sperm adhesion is EBR1, a novel ADAMTS protein. Genes Dev 17: 2502-2507.
73. Kamel C, Veno PA, Kinsey WH. 1986. Quantitation of a src-like tyrosine protein kinase during fertilization of the sea urchin egg. Biochem Biophys Res Commun 138: 349-355.
74. Ketterer B, Hicks RM, Christodoulides L, Beale D. 1973. Studies of the chemistry of the luminal plasma membrane of rat bladder epithelial cells. Biochim Biophys Acta 311: 180-190.
75. Khandelwal P, Abraham SN, Apodaca G. 2009. Cell biology and physiology of the uroepithelium. Am J Physiol Renal Physiol 297: F1477-F1501.
76. Kinsey WH. 1984. Regulation of tyrosine-specific kinase activity at fertilization. Dev Biol 105: 137-143.
77. Kinsey WH. 1996. Biphasic activation of Fyn kinase upon fertilization of the sea urchin egg. Dev Biol 174: 281-287.
78. Kinsey WH. 1997. Tyrosine kinase signaling at fertilization. Biochem Biophys Res Commun 240: 519-522.
79. Kinsey WH, Shen SS. 2000. Role of the Fyn kinase in calcium release during fertilization of the sea urchin egg. Dev Biol 225: 253-264.
80. Kinsey WH, Wu W, Macgregor E. 2003. Activation of Src-family PTK activity at fertilization: Role of the SH2 domain. Dev Biol 264: 255-262.
81. Kondoh G, Tojo H, Nakatani Y, Komazawa N, Murata C, Yamagata K, Maeda Y, Kinoshita T, Okabe M, Taguchi R, Takeda J. 2005. Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. Nat Med 11: 160-166.
82. Kong XT, Deng FM, Hu P, Liang FX, Zhou G, Auerbach AB, Genieser N, Nelson PK, Robbins ES, Shapiro E, Kachar B, Sun TT. 2004. Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases. J Cell Biol 167: 1195-1204.
83. Konno A, Padma P, Ushimaru Y, Inaba K. 2010. Multidimensional analysis of uncharacterized sperm proteins in Ciona intestinalis: EST-based analysis and functional immunoscreening of testis-expressed genes. Zoolog Sci 27: 204-215.
84. Krylov AV, Pohl P, Zeidel ML, Hill WG. 2001. Water permeability of asymmetric planar lipid bilayers: Leaflets of different composition offer independent and additive resistances to permeation. J Gen Physiol 118: 333-340.
85. Kubo H, Shiga K, Harada Y, Iwao Y. 2010. Analysis of a sperm surface molecule that binds to a vitelline envelope component of Xenopus laevis eggs. Mol Reprod Dev 77: 728-735.
86. Kurokawa M, Sato K, Smyth J, Wu H, Fukami K, Takenawa T, Fissore RA. 2004. Evidence that activation of Src family kinase is not required for fertilization-associated [Ca2+]i oscillations in mouse eggs. Reproduction 127: 441-454.
87. Kusumi A, Ike H, Nakada C, Murase K, Fujiwara T. 2005a. Single-molecule tracking of membrane molecules: Plasma membrane compartmentalization and dynamic assembly of raft-philic signaling molecules. Semin Immunol 17: 3-21.
88. Kusumi A, Nakada C, Ritchie K, Murase K, Suzuki K, Murakoshi H, Kasai RS, Kondo J, Fujiwara T. 2005b. Paradigm shift of the plasma membrane concept from the two-dimensional continuum fluid to the partitioned fluid: High-speed single-molecule tracking of membrane molecules. Annu Rev Biophys Biomol Struct 34: 351-378.
89. Lagerholm BC, Weinreb GE, Jacobson K, Thompson NL. 2005. Detecting microdomains in intact cell membranes. Annu Rev Phys Chem 56: 309-336.
90. Lande MB, Donovan JM, Zeidel ML. 1995. The relationship between membrane fluidity and permeabilities to water, solutes, ammonia, and protons. J Gen Physiol 106: 67-84.
91. Le Naour F, Rubinstein E, Jasmin C, Prenant M, Boucheix C. 2000. Severely reduced female fertility in CD9-deficient mice. Science 287: 319-321.
92. Levi M, Shalgi R. 2010. The role of Fyn kinase in the release from metaphase in mammalian oocytes. Mol Cell Endocrinol 314: 228-233.
93. Levy S, Shoham T. 2005. The tetraspanin web modulates immune-signalling complexes. Nat Rev Immunol 5: 136-148.
94. Liang F, Kachar B, Ding M, Zhai Z, Wu XR, Sun TT. 1999. Urothelial hinge as a highly specialized membrane: Detergent-insolubility, urohingin association, and in vitro formation. Differentiation 65: 59-69.
95. Liang FX, Riedel I, Deng FM, Zhou G, Xu C, Wu XR, Kong XP, Moll R, Sun TT. 2001. Organization of uroplakin subunits: Transmembrane topology, pair formation and plaque composition. Biochem J 355: 13-18.
96. Lin JH, Wu XR, Kreibich G, Sun TT. 1994. Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membrane. J Biol Chem 269: 1775-1784.
97. Liu Y, Misamore MJ, Snell WJ. 2010. Membrane fusion triggers rapid degradation of two gamete-specific, fusion-essential proteins in a membrane block to polygamy in Chlamydomonas. Development 137: 1473-1481.
98. Luria A, Vegelyte-Avery V, Stith B, Tsvetkova NM, Wolkers WF, Crowe JH, Tablin F, Nuccitelli R. 2002. Detergent-free domain isolated from Xenopus egg plasma membrane with properties similar to those of detergent-resistant membranes. Biochemistry 41: 13189-13197.
99. Maehashi E, Sato C, Ohta K, Harada Y, Matsuda T, Hirohashi N, Lennarz WJ, Kitajima K. 2003. Identification of the sea urchin 350-kDa sperm-binding protein as a new sialic acid-binding lectin that belongs to the heat shock protein 110 family: Implication of its binding to gangliosides in sperm lipid rafts in fertilization. J Biol Chem 278: 42050-42057.
100. Mahbub Hasan AK, Sato K, Sakakibara K, Ou Z, Iwasaki T, Ueda Y, Fukami Y. 2005. Uroplakin III, a novel Src substrate in Xenopus egg rafts, is a target for sperm protease essential for fertilization. Dev Biol 286: 483-492.
101. Mahbub Hasan AK, Ou Z, Sakakibara K, Hirahara S, Iwasaki T, Sato K, Fukami Y. 2007. Characterization of Xenopus egg membrane microdomains containing uroplakin Ib/III complex: Roles of their molecular interactions for subcellular localization and signal transduction. Genes Cells 12: 251-267.
102. Mammadova G, Iwasaki T, Tokmakov AA, Fukami Y, Sato K. 2009. Evidence that phosphatidylinositol 3-kinase is involved in sperm-induced tyrosine kinase signaling in Xenopus egg fertilization. BMC Dev Biol 9: 68.
103. Martin GS. 2001. The hunting of the Src. Nat Rev Mol Cell Biol 2: 467-475.
104. McGinnis LK, Albertini DF, Kinsey WH. 2007. Localized activation of Src-family protein kinases in the mouse egg. Dev Biol 306: 241-254.
105. McGinnis LK, Kinsey WH, Albertini DF. 2009. Functions of Fyn kinase in the completion of meiosis in mouse oocytes. Dev Biol 327: 280-287.
106. Mehlmann LM, Jaffe LA. 2005. SH2 domain-mediated activation of an SRC family kinase is not required to initiate Ca2+ release at fertilization in mouse eggs. Reproduction 129: 557-564.
107. Mehlmann LM, Chattopadhyay A, Carpenter G, Jaffe LA. 2001. Evidence that phospholipase C from the sperm is not responsible for initiating Ca(2+) release at fertilization in mouse eggs. Dev Biol 236: 492-501.
108. Min G, Stolz M, Zhou G, Liang F, Sebbel P, Stoffler D, Glockshuber R, Sun TT, Aebi U, Kong XP. 2002. Localization of uroplakin Ia, the urothelial receptor for bacterial adhesin FimH, on the six inner domains of the 16nm urothelial plaque particle. J Mol Biol 317: 697-706.
109. Min G, Wang H, Sun TT, Kong XP. 2006. Structural basis for tetraspanin functions as revealed by the cryo-EM structure of uroplakin complexes at 6-A resolution. J Cell Biol 173: 975-983.
110. Miranda PV, Allaire A, Sosnik J, Visconti PE. 2009. Localization of low-density detergent-resistant membrane proteins in intact and acrosome-reacted mouse sperm. Biol Reprod 80: 897-904.
111. Miyado K, Yamada G, Yamada S, Hasuwa H, Nakamura Y, Ryu F, Suzuki K, Kosai K, Inoue K, Ogura A, Okabe M, Mekada E. 2000. Requirement of CD9 on the egg plasma membrane for fertilization. Science 287: 321-324.
112. Miyado K, Yoshida K, Yamagata K, Sakakibara K, Okabe M, Wang X, Miyamoto K, Akutsu H, Kondo T, Takahashi Y, Ban T, Ito C, Toshimori K, Nakamura A, Ito M, Miyado M, Mekada E, Umezawa A. 2008. The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice. Proc Natl Acad Sci USA 105: 12921-12926.
113. Mizote A, Okamoto S, Iwao Y. 1999. Activation of Xenopus eggs by proteases: Possible involvement of a sperm protease in fertilization. Dev Biol 208: 79-92.
114. Moore KL, Kinsey WH. 1995. Effects of protein tyrosine kinase inhibitors on egg activation and fertilization-dependent protein tyrosine kinase activity. Dev Biol 168: 1-10.
115. Mori T, Kuroiwa H, Higashiyama T, Kuroiwa T. 2006. Generative cell specific 1 is essential for angiosperm fertilization. Nat Cell Biol 8: 64-71.
116. Mori T, Hirai M, Kuroiwa T, Miyagishima SY. 2010. The functional domain of GCS1-based gamete fusion resides in the amino terminus in plant and parasite species. PLoS ONE 5: e15957.
117. Munro S. 2003. Lipid rafts: Elusive or illusive? Cell 115: 377-388.
118. Nagai K, Ishida T, Hashimoto T, Harada Y, Ueno S, Ueda Y, Kubo H, Iwao Y. 2009. The sperm-surface glycoprotein, SGP, is necessary for fertilization in the frog, Xenopus laevis. Dev Growth Differ 51: 499-510.
119. Naruse M, Suetomo H, Matsubara T, Sato T, Yanagawa H, Hoshi M, Matsumoto M. 2010. Acrosome reaction-related steroidal saponin, Co-ARIS, from the starfish induces structural changes in microdomains. Dev Biol 347: 147-153.
120. Nishimura H, Cho C, Branciforte DR, Myles DG, Primakoff P. 2001. Analysis of loss of adhesive function in sperm lacking cyritestin or fertilin beta. Dev Biol 233: 204-213.
121. Nishimura H, Myles DG, Primakoff P. 2007. Identification of an ADAM2-ADAM3 complex on the surface of mouse testicular germ cells and cauda epididymal sperm. J Biol Chem 282: 17900-17907.
122. Nixon B, Bielanowicz A, McLaughlin EA, Tanphaichitr N, Ensslin MA, Aitken RJ. 2009. Composition and significance of detergent resistant membranes in mouse spermatozoa. J Cell Physiol 218: 122-134.
123. Nixon B, Mitchell LA, Anderson A, McLaughlin EA, O'Bryan MK, Aitken RJ. 2010. Proteomic and functional analysis of human sperm detergent resistant membranes. J Cell Physiol: in press.
124. Ohta K, Sato C, Matsuda T, Toriyama M, Lennarz WJ, Kitajima K. 1999. Isolation and characterization of low density detergent-insoluble membrane (LD-DIM) fraction from sea urchin sperm. Biochem Biophys Res Commun 258: 616-623.
125. Ohta K, Sato C, Matsuda T, Toriyama M, Vacquier VD, Lennarz WJ, Kitajima K. 2000. Co-localization of receptor and transducer proteins in the glycosphingolipid-enriched, low density, detergent-insoluble membrane fraction of sea urchin sperm. Glycoconj J 17: 205-214.
126. Olsburgh J, Harnden P, Weeks R, Smith B, Joyce A, Hall G, Poulsom R, Selby P, Southgate J. 2003. Uroplakin gene expression in normal human tissues and locally advanced bladder cancer. J Pathol 199: 41-49.
127. O'Neill FJ, Gillett J, Foltz KR. 2004. Distinct roles for multiple Src family kinases at fertilization. J Cell Sci 117: 6227-6238.
128. Parton RG, Simons K. 1995. Digging into caveolae. Science 269: 1398-1399.
129. Pike LJ. 2006. Rafts defined: A report on the keystone symposium on lipid rafts and cell function. J Lipid Res 47: 1597-1598.
130. Pike LJ. 2009. The challenge of lipid rafts. J Lipid Res 50: S323-S328.
131. Primakoff P, Myles DG. 2002. Penetration, adhesion, and fusion in mammalian sperm-egg interaction. Science 296: 2183-2185.
132. Qi JC, Wang J, Mandadi S, Tanaka K, Roufogalis BD, Madigan MC, Lai K, Yan F, Chong BH, Stevens RL, Krilis SA. 2006. Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor. Blood 107: 135-142.
133. Resh MD. 1999. Fatty acylation of proteins: New insights into membrane targeting of myristoylated and palmitoylated proteins. Biochim Biophys Acta 1451: 1-16.
134. Ribot HD, Jr., Eisenman EA, Kinsey WH. 1984. Fertilization results in increased tyrosine phosphorylation of egg proteins. J Biol Chem 259: 5333-5338.
135. Rubinstein E, Ziyyat A, Prenant M, Wrobel E, Wolf JP, Levy S, Le Naour F, Boucheix C. 2006. Reduced fertility of female mice lacking CD81. Dev Biol 290: 351-358.
136. Runft LL, Jaffe LA. 2000. Sperm extract injection into ascidian eggs signals Ca(2+) release by the same pathway as fertilization. Development 127: 3227-3236.
137. Runft LL, Watras J, Jaffe LA. 1999. Calcium release at fertilization of Xenopus eggs requires type I IP(3) receptors, but not SH2 domain-mediated activation of PLCgamma or G(q)-mediated activation of PLCbeta. Dev Biol 214: 399-411.
138. Sadler SE. 2001. Low-density caveolae-like membrane from Xenopus laevis oocytes is enriched in Ras. J Cell Biochem 83: 21-32.
139. Sakakibara K, Sato K, Yoshino K, Oshiro N, Hirahara S, Mahbub Hasan AK, Iwasaki T, Ueda Y, Iwao Y, Yonezawa K, Fukami Y. 2005. Molecular identification and characterization of Xenopus egg uroplakin III, an egg raft-associated transmembrane protein that is tyrosine-phosphorylated upon fertilization. J Biol Chem 280: 15029-15037.
140. Sato K, Aoto M, Mori K, Akasofu S, Tokmakov AA, Sahara S, Fukami Y. 1996. Purification and characterization of a Src-related p57 protein-tyrosine kinase from Xenopus oocytes. Isolation of an inactive form of the enzyme and its activation and translocation upon fertilization. J Biol Chem 271: 13250-13257.
141. Sato K, Iwasaki T, Tamaki I, Aoto M, Tokmakov AA, Fukami Y. 1998. Involvement of protein-tyrosine phosphorylation and dephosphorylation in sperm-induced Xenopus egg activation. FEBS Lett 424: 113-118.
142. Sato K, Iwao Y, Fujimura T, Tamaki I, Ogawa K, Iwasaki T, Tokmakov AA, Hatano O, Fukami Y. 1999. Evidence for the involvement of a Src-related tyrosine kinase in Xenopus egg activation. Dev Biol 209: 308-320.
143. Sato K, Tokmakov AA, Fukami Y. 2000a. Fertilization signalling and protein-tyrosine kinases. Comp Biochem Physiol B Biochem Mol Biol 126: 129-148.
144. Sato K, Tokmakov AA, Iwasaki T, Fukami Y. 2000b. Tyrosine kinase-dependent activation of phospholipase Cgamma is required for calcium transient in Xenopus egg fertilization. Dev Biol 224: 453-469.
145. Sato K, Iwasaki T, Ogawa K, Konishi M, Tokmakov AA, Fukami Y. 2002. Low density detergent-insoluble membrane of Xenopus eggs: Subcellular microdomain for tyrosine kinase signaling in fertilization. Development 129: 885-896.
146. Sato K, Tokmakov AA, He CL, Kurokawa M, Iwasaki T, Shirouzu M, Fissore RA, Yokoyama S, Fukami Y. 2003. Reconstitution of Src-dependent phospholipase Cgamma phosphorylation and transient calcium release by using membrane rafts and cell-free extracts from Xenopus eggs. J Biol Chem 278: 38413-38420.
147. Sato K, Fukami Y, Stith BJ. 2006a. Signal transduction pathways leading to Ca2+ release in a vertebrate model system: Lessons from Xenopus eggs. Semin Cell Dev Biol 17: 285-292.
148. Sato K, Yoshino K, Tokmakov AA, Iwasaki T, Yonezawa K, Fukami Y. 2006b. Studying fertilization in cell-free extracts: Focusing on membrane/lipid raft functions and proteomics. Methods Mol Biol 322: 395-411.
149. Schroeder R, London E, Brown D. 1994. Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior. Proc Natl Acad Sci USA 91: 12130-12134.
150. Selvaraj V, Asano A, Buttke DE, McElwee JL, Nelson JL, Wolff CA, Merdiushev T, Fornes MW, Cohen AW, Lisanti MP, Rothblat GH, Kopf GS, Travis AJ. 2006. Segregation of micron-scale membrane sub-domains in live murine sperm. J Cell Physiol 206: 636-646.
151. Selvaraj V, Asano A, Buttke DE, Sengupta P, Weiss RS, Travis AJ. 2009. Mechanisms underlying the micron-scale segregation of sterols and GM1 in live mammalian sperm. J Cell Physiol 218: 522-536.
152. Sette C, Paronetto MP, Barchi M, Bevilacqua A, Geremia R, Rossi P. 2002. Tr-kit-induced resumption of the cell cycle in mouse eggs requires activation of a Src-like kinase. EMBO J 21: 5386-5395.
153. Shadan S, James PS, Howes EA, Jones R. 2004. Cholesterol efflux alters lipid raft stability and distribution during capacitation of boar spermatozoa. Biol Reprod 71: 253-265.
154. Shapiro E, Huang HY, Wu XR. 2000. Uroplakin and androgen receptor expression in the human fetal genital tract: Insights into the development of the vagina. J Urol 164: 1048-1051.
155. Sharma D, Kinsey WH. 2006. Fertilization triggers localized activation of Src-family protein kinases in the zebrafish egg. Dev Biol 295: 604-614.
156. Shearer J, De Nadai C, Emily-Fenouil F, Gache C, Whitaker M, Ciapa B. 1999. Role of phospholipase Cgamma at fertilization and during mitosis in sea urchin eggs and embryos. Development 126: 2273-2284.
157. Shilling FM, Kratzschmar J, Cai H, Weskamp G, Gayko U, Leibow J, Myles DG, Nuccitelli R, Blobel CP. 1997. Identification of metalloprotease/disintegrins in Xenopus laevis testis with a potential role in fertilization. Dev Biol 186: 155-164.
158. Shilling FM, Magie CR, Nuccitelli R. 1998. Voltage-dependent activation of frog eggs by a sperm surface disintegrin peptide. Dev Biol 202: 113-124.
159. Shoeb M, Laloraya M, Kumar PG. 2004. Formation and dynamic alterations of horizontal microdomains in sperm membranes during progesterone-induced acrosome reaction. Biochem Biophys Res Commun 315: 763-770.
160. Shogomori H, Brown DA. 2003. Use of detergents to study membrane rafts: The good, the bad, and the ugly. Biol Chem 384: 1259-1263.
161. Simons K, Gerl MJ. 2010. Revitalizing membrane rafts: New tools and insights. Nat Rev Mol Cell Biol 11: 688-699.
162. Simons K, Ikonen E. 1997. Functional rafts in cell membranes. Nature 387: 569-572.
163. Simons K, Toomre D. 2000. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1: 31-39.
164. Singer SJ, Nicolson GL. 1972. The fluid mosaic model of the structure of cell membranes. Science 175: 720-731.
165. Sleight SB, Miranda PV, Plaskett NW, Maier B, Lysiak J, Scrable H, Herr JC, Visconti PE. 2005. Isolation and proteomic analysis of mouse sperm detergent-resistant membrane fractions: Evidence for dissociation of lipid rafts during capacitation. Biol Reprod 73: 721-729.
166. Staehelin LA, Chlapowski FJ, Bonneville MA. 1972. Lumenal plasma membrane of the urinary bladder. I. Three-dimensional reconstruction from freeze-etch images. J Cell Biol 53: 73-91.
167. Steele RE, Dana CE. 2009. Evolutionary history of the HAP2/GCS1 gene and sexual reproduction in metazoans. PLoS ONE 4: e7680.
168. Stipp CS, Kolesnikova TV, Hemler ME. 2003. Functional domains in tetraspanin proteins. Trends Biochem Sci 28: 106-112.
169. Sun TT. 2006. Altered phenotype of cultured urothelial and other stratified epithelial cells: Implications for wound healing. Am J Physiol Renal Physiol 291: F9-F21.
170. Suzuki KG, Fujiwara TK, Edidin M, Kusumi A. 2007a. Dynamic recruitment of phospholipase C gamma at transiently immobilized GPI-anchored receptor clusters induces IP3-Ca2+ signaling: Single-molecule tracking study 2. J Cell Biol 177: 731-742.
171. Suzuki KG, Fujiwara TK, Sanematsu F, Iino R, Edidin M, Kusumi A. 2007b. GPI-anchored receptor clusters transiently recruit Lyn and G alpha for temporary cluster immobilization and Lyn activation: Single-molecule tracking study 1. J Cell Biol 177: 717-730.
172. Talmor-Cohen A, Tomashov-Matar R, Eliyahu E, Shapiro R, Shalgi R. 2004. Are Src family kinases involved in cell cycle resumption in rat eggs? Reproduction 127: 455-463.
173. Tanphaichitr N, Carmona E, Bou Khalil M, Xu H, Berger T, Gerton GL. 2007. New insights into sperm-zona pellucida interaction: Involvement of sperm lipid rafts. Front Biosci 12: 1748-1766.
174. Taylor KA, Robertson JD. 1984. Analysis of the three-dimensional structure of the urinary bladder epithelial cell membranes. J Ultrastruct Res 87: 23-30.
175. Thaler CD, Thomas M, Ramalie JR. 2006. Reorganization of mouse sperm lipid rafts by capacitation. Mol Reprod Dev 73: 1541-1549.
176. Thomas SM, Brugge JS. 1997. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 13: 513-609.
177. Thumbikat P, Berry RE, Schaeffer AJ, Klumpp DJ. 2009a. Differentiation-induced uroplakin III expression promotes urothelial cell death in response to uropathogenic E. coli Microbes Infect 11: 57-65.
178. Thumbikat P, Berry RE, Zhou G, Billips BK, Yaggie RE, Zaichuk T, Sun TT, Schaeffer AJ, Klumpp DJ. 2009b. Bacteria-induced uroplakin signaling mediates bladder response to infection. PLoS Pathog 5: e1000415.
179. Townley IK, Roux MM, Foltz KR. 2006. Signal transduction at fertilization: The Ca2+ release pathway in echinoderms and other invertebrate deuterostomes. Semin Cell Dev Biol 17: 293-302.
180. Townley IK, Schuyler E, Parker-Gur M, Foltz KR. 2009. Expression of multiple Src family kinases in sea urchin eggs and their function in Ca2+ release at fertilization. Dev Biol 327: 465-477.
181. Travis AJ, Merdiushev T, Vargas LA, Jones BH, Purdon MA, Nipper RW, Galatioto J, Moss SB, Hunnicutt GR, Kopf GS. 2001. Expression and localization of caveolin-1, and the presence of membrane rafts, in mouse and Guinea pig spermatozoa. Dev Biol 240: 599-610.
182. Trevino CL, Serrano CJ, Beltran C, Felix R, Darszon A. 2001. Identification of mouse trp homologs and lipid rafts from spermatogenic cells and sperm. FEBS Lett 509: 119-125.
183. Tu L, Sun TT, Kreibich G. 2002. Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum. Mol Biol Cell 13: 4221-4230.
184. Tutuncu L, Stein P, Ord TS, Jorgez CJ, Williams CJ. 2004. Calreticulin on the mouse egg surface mediates transmembrane signaling linked to cell cycle resumption. Dev Biol 270: 246-260.
185. Ueki K, Yokosawa H. 1997. Evidence for an erbstatin-sensitive tyrosine kinase functioning in ascidian egg activation. Biochem Biophys Res Commun 238: 130-133.
186. Urayama S, Harada Y, Nakagawa Y, Ban S, Akasaka M, Kawasaki N, Sawada H. 2008. Ascidian sperm glycosylphosphatidylinositol-anchored CRISP-like protein as a binding partner for an allorecognizable sperm receptor on the vitelline coat. J Biol Chem 283: 21725-21733.
187. Van Heyningen WE, Van Heyningen S, King CA. 1976. The nature and action of cholera toxin. Ciba Found Symp 42: 73-88.
188. van Zanten TS, Cambi A, Koopman M, Joosten B, Figdor CG, Garcia-Parajo MF. 2009. Hotspots of GPI-anchored proteins and integrin nanoclusters function as nucleation sites for cell adhesion. Proc Natl Acad Sci USA 106: 18557-18562.
189. Vergara J, Zambrano F, Robertson JD, Elrod H. 1974. Isolation and characterization of luminal membranes from urinary bladder. J Cell Biol 61: 83-94.
190. Visconti PE, Kopf GS. 1998. Regulation of protein phosphorylation during sperm capacitation. Biol Reprod 59: 1-6.
191. Visconti PE, Bailey JL, Moore GD, Pan D, Olds-Clarke P, Kopf GS. 1995a. Capacitation of mouse spermatozoa. I. Correlation between the capacitation state and protein tyrosine phosphorylation. Development 121: 1129-1137.
192. Visconti PE, Moore GD, Bailey JL, Leclerc P, Connors SA, Pan D, Olds-Clarke P, Kopf GS. 1995b. Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway. Development 121: 1139-1150.
193. Visconti PE, Galantino-Homer H, Ning X, Moore GD, Valenzuela JP, Jorgez CJ, Alvarez JG, Kopf GS. 1999a. Cholesterol efflux-mediated signal transduction in mammalian sperm. beta-cyclodextrins initiate transmembrane signaling leading to an increase in protein tyrosine phosphorylation and capacitation. J Biol Chem 274: 3235-3242.
194. Visconti PE, Ning X, Fornes MW, Alvarez JG, Stein P, Connors SA, Kopf GS. 1999b. Cholesterol efflux-mediated signal transduction in mammalian sperm: Cholesterol release signals an increase in protein tyrosine phosphorylation during mouse sperm capacitation. Dev Biol 214: 429-443.
195. Walz T, Haner M, Wu XR, Henn C, Engel A, Sun TT, Aebi U. 1995. Towards the molecular architecture of the asymmetric unit membrane of the mammalian urinary bladder epithelium: A closed "twisted ribbon" structure. J Mol Biol 248: 887-900.
196. Waugh MG, Lawson D, Hsuan JJ. 1999. Epidermal growth factor receptor activation is localized within low-buoyant density, non-caveolar membrane domains. Biochem J 337: 591-597.
197. Weerachatyanukul W, Probodh I, Kongmanas K, Tanphaichitr N, Johnston LJ. 2007. Visualizing the localization of sulfoglycolipids in lipid raft domains in model membranes and sperm membrane extracts. Biochim Biophys Acta 1768: 299-310.
198. Wessel GM, Wong JL. 2009. Cell surface changes in the egg at fertilization. Mol Reprod Dev 76: 942-953.
199. Wong JL, Johnson MA. 2010. Is HAP2-GCS1 an ancestral gamete fusogen? Trends Cell Biol 20: 134-141.
200. Wong JL, Wessel GM. 2008. Renovation of the egg extracellular matrix at fertilization. Int J Dev Biol 52: 545-550.
201. Wu W, Kinsey WH. 2000. Fertilization triggers activation of Fyn kinase in the zebrafish egg. Int J Dev Biol 44: 837-841.
202. Wu XR, Sun TT. 1993. Molecular cloning of a 47kDa tissue-specific and differentiation-dependent urothelial cell surface glycoprotein. J Cell Sci 106: 31-43.
203. Wu XR, Manabe M, Yu J, Sun TT. 1990. Large scale purification and immunolocalization of bovine uroplakins I, II, and III. Molecular markers of urothelial differentiation. J Biol Chem 265: 19170-19179.
204. Wu XR, Lin JH, Walz T, Haner M, Yu J, Aebi U, Sun TT. 1994. Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins. J Biol Chem 269: 13716-13724.
205. Wu XR, Medina JJ, Sun TT. 1995. Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells. J Biol Chem 270: 29752-29759.
206. Wu XR, Kong XP, Pellicer A, Kreibich G, Sun TT. 2009. Uroplakins in urothelial biology, function, and disease. Kidney Int 75: 1153-1165.
207. Xie B, Zhou G, Chan SY, Shapiro E, Kong XP, Wu XR, Sun TT, Costello CE. 2006. Distinct glycan structures of uroplakins Ia and Ib: Structural basis for the selective binding of FimH adhesin to uroplakin Ia. J Biol Chem 281: 14644-14653.
208. Yamada E. 1955. The fine structure of the gall bladder epithelium of the mouse. J Biophys Biochem Cytol 1: 445-458.
209. Yanagimachi R. 1994. Mammalian fertilization. In: Knobil E, Neil J, editors. The physiology of reproduction. New York: Raven Press. p 135-185.
210. Yim DL, Opresko LK, Wiley HS, Nuccitelli R. 1994. Highly polarized EGF receptor tyrosine kinase activity initiates egg activation in Xenopus. Dev Biol 162: 41-55.
211. Yu J, Lin JH, Wu XR, Sun TT. 1994. Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins. J Cell Biol 125: 171-182.
212. Zee YP, Holt WV, Allen CD, Nicolson V, Burridge M, Lisle A, Carrick FN, Johnston SD. 2007. Effects of cryopreservation on mitochondrial function and heterogeneity, lipid raft stability and phosphatidylserine translocation in koala (Phascolarctos cinereus) spermatozoa. Reprod Fertil Dev 19: 850-860.
213. Zhou G, Mo WJ, Sebbel P, Min G, Neubert TA, Glockshuber R, Wu XR, Sun TT, Kong XP. 2001. Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: Evidence from in vitro FimH binding. J Cell Sci 114: 4095-4103.
214. Zhou GB, Liu GS, Meng QG, Liu Y, Hou YP, Wang XX, Li N, Zhu SE. 2009. Tetraspanin CD9 in bovine oocytes and its role in fertilization. J Reprod Dev 55: 305-308.