Mechanisms for Kir channel inhibition by quinacrine: Acute pore block of Kir2.x channels and interference in PIP 2 interaction with Kir2.x and Kir6.2 channels

Pflugers Archiv European Journal of Physiology

Volumn 462, Issue 4, 2011, Pages 505-517

  López Izquierdo, Angélica ^a   Aréchiga Figueroa, Iván A ^a   Moreno Galindo, Eloy G ^a   Ponce Balbuena, Daniela ^a   Rodríguez Martínez, Martín ^a   Ferrer Villada, Tania ^a   Rodríguez Menchaca, Aldo A ^c   Van Der Heyden, Marcel A G ^b   Sánchez Chapula, José A ^a  

^a UNIVERSIDAD DE COLIMA   (Mexico)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

Author keywords

Inward rectifier potassium channels; Kir2.1; Kir2.3; Kir6.2; Phosphatidylinositol 4,5 bisphosphate, PIP 2; Quinacrine

Indexed keywords

INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.X; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; MEPACRINE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELLULAR DISTRIBUTION; CHANNEL GATING; CONTROLLED STUDY; DRUG MECHANISM; DRUG SENSITIVITY; DRUG TARGETING; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IC 50; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RESIDUE ANALYSIS; SENSITIVITY ANALYSIS;

HEK293 CELLS; HUMANS; MYOCYTES, CARDIAC; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; POTASSIUM CHANNELS, INWARDLY RECTIFYING; QUINACRINE;

EID: 80054748048     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-011-0995-5     Document Type: Article

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