Specific residues of the cytoplasmic domains of cardiac inward rectifier potassium channels are effective antifibrillatory targets

FASEB Journal

Volumn 24, Issue 11, 2010, Pages 4302-4312

  Noujaim, Sami F ^a   Stuckey, Jeanne A ^a   Ponce Balbuena, Daniela ^b   Ferrer Villada, Tania ^b   López Izquierdo, Angelica ^b   Pandit, Sandeep ^a   Calvo, Conrado J ^a   Grzeda, Krzysztof R ^a   Berenfeld, Omer ^a   Chapula, José A Sánchez ^b   Jalife, José ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSIDAD DE COLIMA   (Mexico)

Author keywords

Chloroquine; Fibrillation; IK1; IKAch; IKATP

Indexed keywords

AMINO ACID; CHLOROQUINE; CYTOPLASM PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR3.1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; ION; LIGAND; PINACIDIL; POTASSIUM; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENCY; DRUG PROTEIN BINDING; HEART; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART VENTRICLE FIBRILLATION; INTRACELLULAR MEMBRANE; INTRACORONARY INFUSION; ION PERMEABILITY; ISOLATED HEART; LIGAND BINDING; MAMMAL; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN DOMAIN; RABBIT; SHEEP; SINUS RHYTHM; VESTIBULE;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CHLOROQUINE; CYTOPLASM; HEART; MICE; MODELS, MOLECULAR; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RABBITS; RECEPTORS, KIR; SHEEP; TACHYCARDIA, VENTRICULAR; VENTRICULAR FIBRILLATION;

MAMMALIA;

EID: 78649856686     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-163246     Document Type: Article

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