SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors

Cancer Chemotherapy and Pharmacology

Volumn 68, Issue 4, 2011, Pages 923-933

  Basso, Andrea D ^a   Liu, Ming ^a   Gray, Kimberly ^a   Tevar, Seema ^a   Lee, Suining ^a   Liang, Lianzhu ^a   Ponery, Abdul ^a   Smith, Elizabeth B ^a   Monsma Jr , Frederick J ^a   Yu, Tao ^a   Zhang, Yonglian ^a   Kerekes, Angela D ^a   Esposite, Sara ^a   Xiao, Yushi ^a   Tagat, Jayaram R ^a   Hicklin, Daniel J ^a   Kirschmeier, Paul ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aurora; KSP; Taxane

Indexed keywords

AURORA A KINASE; AURORA B KINASE; AURORA KINASE INHIBITOR; CELL DNA; DOCETAXEL; HISTONE H3; ISPINESIB; PACLITAXEL; SCH 1473759; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CONTENT; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSAGE FORM COMPARISON; DRUG DOSE COMPARISON; DRUG DOSE REGIMEN; DRUG DOSE SEQUENCE; DRUG EFFICACY; DRUG INTERMITTENT THERAPY; DRUG POTENCY; DRUG POTENTIATION; DRUG SENSITIVITY; DRUG TOLERABILITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; MAXIMUM TOLERATED DOSE; MITOSIS INHIBITION; MONOTHERAPY; MOUSE; NONHUMAN; OVARY TUMOR; PHARMACODYNAMICS; PRIORITY JOURNAL; PROSTATE TUMOR; PROTEIN PHOSPHORYLATION; SINGLE DRUG DOSE; TUMOR CELL LINE; TUMOR VOLUME; TUMOR XENOGRAFT; WEIGHT GAIN;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL LINE, TUMOR; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; IMIDAZOLES; KINESIN; MALE; MICE; MICE, NUDE; NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PYRAZINES; TAXOIDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80054735812     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-011-1568-1     Document Type: Article

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