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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 22, 2011, Pages 6646-6651

7-Oxopyrrolopyridine-derived DPP4 inhibitors - Mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site

(17) Wang, Wei a Devasthale, Pratik a Wang, Aiying a Harrity, Tom a Egan, Don a Morgan, Nathan a Cap, Michael a Fura, Aberra a Klei, Herbert E a Kish, Kevin a Weigelt, Carolyn a Sun, Lucy a Levesque, Paul a Li, Yi Xin a Zahler, Robert a Kirby, Mark S a Hamann, Lawrence G a,b

a BRISTOL MYERS SQUIBB (United States)

b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH (United States)

Author keywords

7 Oxopyrrolopyridines; Atropisomers; Diabetes mellitus; DPP4 inhibitors

Indexed keywords

7 OXOPYRROLOPYRIDINE DERIVATIVE; ANTIDIABETIC AGENT; CYTOCHROME P450 3A4; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; POTASSIUM CHANNEL HERG; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; INSULIN RESPONSE; MOUSE; NONHUMAN; POLARIZATION; RAT; STEREOCHEMISTRY;

ANIMALS; CATALYTIC DOMAIN; CYTOCHROME P-450 CYP3A; DIABETES MELLITUS; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; INSULIN; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; PYRIDINES; PYRROLES; RATS; STEREOISOMERISM;

MUS;

EID: 80054734762 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.09.074 Document Type: Article

Times cited : (20)

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