Synthesis, SAR, and atropisomerism of imidazolopyrimidine DPP4 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 21, 2010, Pages 6273-6276

  O'Connor, Stephen P ^a   Wang, Ying ^a   Simpkins, Ligaya M ^a   Brigance, Robert P ^a   Meng, Wei ^a   Wang, Aiying ^a   Kirby, Mark S ^a   Weigelt, Carolyn A ^a   Hamann, Lawrence G ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Atropisomerism; Dipeptidyl peptidase 4; DPP4

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; IMIDAZOLOPYRIMIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ATROPISOMERISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

CATALYTIC DOMAIN; DIPEPTIDASES; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; IMIDAZOLES; INDICATORS AND REAGENTS; ISOMERISM; KINETICS; MODELS, MOLECULAR; PYRIMIDINES; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77957887651     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.090     Document Type: Article

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