Aminomethylpyridines as DPP-IV inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 13, 2004, Pages 3579-3580

  Peters, Jens Uwe ^a   Weber, Silja ^a   Kritter, Stéphane ^a   Weiss, Peter ^a   Wallier, Angelina ^a   Zimmerli, Daniel ^a   Boehringer, Markus ^a   Steger, Matthias ^a,b   Loeffler, Bernd Michael ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b ACTELION PHARMACEUTICALS LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOMETHYLPYRIDINE DERIVATIVE; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; ENZYME INHIBITOR; PICOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING;

AMINES; ANTIGENS, CD26; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; ENZYME INHIBITORS; HYDROCARBONS, AROMATIC; INHIBITORY CONCENTRATION 50; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2942532819     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.04.049     Document Type: Article

References (19)

1. For reviews, see: Drucker D.J. Diabetes Care. 26:2003;2929
2. Holst J.J., Orskov C. Scand. J. Clin. Lab. Invest. 61(Suppl. 234):2001;75
3. Creutzfeldt W. Exp. Clin. Endocrinol. Diabetes. 109(Suppl. 2):2001;S288
4. Mojsov S., Weir G.C., Habener J.F. J. Clin. Invest. 79:1987;616
5. Drucker D.J., Philippe J., Mojsov S., Chick W.L., Habener J.F. Proc. Natl. Acad. Sci. U.S.A. 84:1987;3434
6. Orskov C., Holst J.J., Nielsen O.V. Endocrinology. 123:1988;2009
7. Nauck M.A., Heimesaat M.M., Örskov C., Holst J.J., Ebert R., Creutzfeldt W. J. Clin. Invest. 91:1993;301
8. Pauly R.P., Demuth H.U., Rosche F., Schmidt J., White H.A., Lynn F., McIntosh C.H., Pederson R.A. Metab.: Clin. Exp. 48:1999;385
9. Mentlein R., Gallwitz B., Schmidt E. Eur. J. Biochem. 214:1993;829
10. Kiefer T.J., McIntosh C.H.S., Pederson R.A. Endocrinology. 136:1998;3585
11. For reviews, see: Augustyns K., Van der Veken P., Senten K., Haerners A. Expert Opin. Ther. Pat. 13:2003;499
12. Drucker D.J. Expert Opin. Invest. Drugs. 12:2003;87
13. Rosenblum J.S., Kozarich J.W. Curr. Opin. Chem. Biol. 7:2003;496
14. 50 ( x ) measured for NVP-DPP728 in the assay was 11
15. Peters J.-U., Weber S., Kritter S., Weiss P., Wallier A., Boehringer M., Hennig M., Kuhn B., Loeffler B.-M. Bioorg. Med. Chem. Lett. 14:2004;1491
16. Gerber P.R., Müller K. J. Comput. Aided Mol. Des. 9:1995;251
17. Kambe S., Saito K., Sakurai A., Midorikawa H. Synthesis. 1980;366
18. For detailed procedures, see: (a) Boehringer, M.; Loeffler, B.-M.; Peters, J.-U.; Riemer, C.; Weiss, P. International Patent Application WO 03/68748, 2003 (b) Boehringer, M.; Loeffler, B.-M.; Peters, J.-U.; Steger, M.; Weiss, P. International Patent Application WO 03/68757, 2003
19. For detailed procedures, see: (a) Boehringer, M.; Loeffler, B.-M.; Peters, J.-U.; Riemer, C.; Weiss, P. International Patent Application WO 03/68748, 2003 (b) Boehringer, M.; Loeffler, B.-M.; Peters, J.-U.; Steger, M.; Weiss, P. International Patent Application WO 03/68757, 2003