β-blockers protect against dispersion of repolarization during exercise in congenital long-QT syndrome type 1

Journal of Cardiovascular Electrophysiology

Volumn 22, Issue 10, 2011, Pages 1141-1146

  Gemma, Lee W ^a   Ward, Gregory M ^a   Dettmer, Mary M ^a   Ball, Jennifer L ^a   Leo, Peter J ^a   Doria, Danielle N ^a   Kaufman, Elizabeth S ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

blocker therapy; dispersion of ventricular repolarization; long QT syndrome; sudden death; T peak end

Indexed keywords

ATENOLOL; METOPROLOL SUCCINATE; NADOLOL; PROPRANOLOL;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EXERCISE ELECTROCARDIOGRAPHY; EXERCISE TEST; FEMALE; HEART REPOLARIZATION; HUMAN; LONG QT SYNDROME; MALE; PRIORITY JOURNAL; QT DISPERSION; QT INTERVAL; QT PROLONGATION; RANDOMIZED CONTROLLED TRIAL;

ADRENERGIC BETA-ANTAGONISTS; ADULT; DEATH, SUDDEN, CARDIAC; DOUBLE-BLIND METHOD; ELECTROCARDIOGRAPHY; EXERCISE; FEMALE; HEART CONDUCTION SYSTEM; HEART RATE; HUMANS; MALE; MIDDLE AGED; OHIO; PROPRANOLOL; ROMANO-WARD SYNDROME; SYNCOPE; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 80054732661     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/j.1540-8167.2011.02091.x     Document Type: Article

References (33)

1. Swan H, Toivonen L, Viitasalo M,: Rate adaptation of QT intervals during and after exercise in children with congenital long QT syndrome. Eur Heart J 1998; 19: 508-513. (Pubitemid 28120732)
2. Swan H, Viitasalo M, Piippo K, Laitinen P, Kontula K, Toivonen L,: Sinus node function and ventricular repolarization during exercise stress test in long QT syndrome patients with KvLQT1 and HERG potassium channel defects. J Am Coll Cardiol 1999; 34: 823-829. (Pubitemid 29436190)
3. Shimizu W, Ohe T, Kurita T, Shimomura K,: Differential response of QTU interval to exercise, isoproterenol, and atrial pacing in patients with congenital long QT syndrome. Pacing Clin Electrophysiol 1991; 14: 1966-1970.
4. Ackerman MJ, Khositseth A, Tester DJ, Hejlik JB, Shen WK, Porter CB,: Epinephrine-induced QT interval prolongation: A gene-specific paradoxical response in congenital long QT syndrome. Mayo Clin Proc 2002; 77: 413-421. (Pubitemid 34465148)
5. Shimizu W, Noda T, Takaki H, Kurita T, Nagaya N, Satomi K, Suyama K, Aihara N, Kamakura S, Sunagawa K, Echigo S, Nakamura K, Ohe T, Towbin JA, Napolitano C, Priori SG,: Epinephrine unmasks latent mutation carriers with LQT1 form of congenital long-QT syndrome. J Am Coll Cardiol 2003; 41: 633-642. (Pubitemid 36223330)
6. Kaufman ES, Gorodeski EZ, Dettmer MM, Dikshteyn M,: Use of autonomic maneuvers to probe phenotype/genotype discordance in congenital long QT syndrome. Am J Cardiol 2005; 96: 1425-1430. (Pubitemid 41566626)
7. Vyas H, Hejlik J, Ackerman MJ,: Epinephrine QT stress testing in the evaluation of congenital long-QT syndrome: Diagnostic accuracy of the paradoxical QT response. Circulation 2006; 113: 1385-1392. (Pubitemid 43739434)
8. Schwartz PJ, Locati E,: The idiopathic long QT syndrome: Pathogenetic mechanisms and therapy. Eur Heart J 1985; 6 (Suppl D): 103-114. (Pubitemid 16172260)
9. Priori SG, Napolitano C, Schwartz PJ, Grillo M, Bloise R, Ronchetti E, Moncalvo C, Tulipani C, Veia A, Bottelli G, Nastoli J,: Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers. JAMA 2004; 292: 1341-1344. (Pubitemid 39223225)
10. Goldenberg I, Bradley J, Moss A, McNitt S, Polonsky S, Robinson JL, Andrews M, Zareba W,: International LQTS Registry Investigators: Beta-blocker efficacy in high-risk patients with the congenital long-QT syndrome types 1 and 2: implications for patient management. J Cardiovasc Electrophysiol 2010; 21: 893-901.
11. Moss AJ, Zareba W, Hall WJ, Schwartz PJ, Crampton RS, Benhorin J, Vincent GM, Locati EH, Priori SG, Napolitano C, Medina A, Zhang L, Robinson JL, Timothy K, Towbin JA, Andrews ML,: Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome. Circulation 2000; 101: 616-623. (Pubitemid 30094732)
12. Kaltman JR, Ro PS, Stephens P, McBride MG, Cohen MI, Tanel RE, Vetter VL, Rhodes LA,: Effects of beta-adrenergic antagonists on the QT measurements from exercise stress tests in pediatric patients with long QT syndrome. Pediatr Cardiol 2003; 24: 553-558. (Pubitemid 37474378)
13. Wong JA, Gula LJ, Klein GJ, Yee R, Skanes AC, Krahn AD,: Utility of treadmill testing in identification and genotype prediction in long-QT syndrome. Circ Arrhythm Electrophysiol 2010; 3: 120-125.
14. Yan GX, Antzelevitch C,: Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. Circulation 1998; 98: 1928-1936. (Pubitemid 28509291)
15. Antzelevitch C,: T peak-Tend interval as an index of transmural dispersion of repolarization. Eur J Clin Invest 2001; 31: 555-557. (Pubitemid 32642882)
16. Yan GX, Martin J,: Electrocardiographic T wave: A symbol of transmural dispersion of repolarization in the ventricles. J Cardiovasc Electrophysiol 2003; 14: 639-640. (Pubitemid 36724390)
17. end interval as an index of global dispersion of ventricular repolarization: Evaluations using monophasic action potential mapping of the epi- and endocardium in swine. J Interv Card Electrophysiol 2005; 14: 79-87. (Pubitemid 43004736)
18. Xia Y, Liang Y, Kongstad O, Liao Q, Holm M, Olsson B, Yuan S,: In vivo validation of the coincidence of the peak and end of the T wave with full repolarization of the epicardium and endocardium in swine. Heart Rhythm 2005; 2: 162-169. (Pubitemid 40220820)
19. end provide an index of transmural dispersion of repolarization? Heart Rhythm 2007; 4: 1114-1116; author reply 1116-1119. (Pubitemid 47163756)
20. p-e interval does not reflect transmural dispersion. Heart Rhythm 2007; 4: 341-348. (Pubitemid 46323467)
21. Watanabe N, Kobayashi Y, Tanno K, Miyoshi F, Asano T, Kawamura M, Mikami Y, Adachi T, Ryu S, Miyata A, Katagiri T,: Transmural dispersion of repolarization and ventricular tachyarrhythmias. J Electrocardiol 2004; 37: 191-200. (Pubitemid 39013355)
22. Lubinski A, Lewicka-Nowak E, Kempa M, Baczynska AM, Romanowska I, Swiatecka G,: New insight into repolarization abnormalities in patients with congenital long QT syndrome: The increased transmural dispersion of repolarization. Pacing Clin Electrophysiol 1998; 21: 172-175.
23. Tanabe Y, Inagaki M, Kurita T, Nagaya N, Taguchi A, Suyama K, Aihara N, Kamakura S, Sunagawa K, Nakamura K, Ohe T, Towbin JA, Priori SG, Shimizu W,: Sympathetic stimulation produces a greater increase in both transmural and spatial dispersion of repolarization in LQT1 than LQT2 forms of congenital long QT syndrome. J Am Coll Cardiol 2001; 37: 911-919. (Pubitemid 32202463)
24. Takenaka K, Ai T, Shimizu W, Kobori A, Ninomiya T, Otani H, Kubota T, Takaki H, Kamakura S, Horie M,: Exercise stress test amplifies genotype-phenotype correlation in the LQT1 and LQT2 forms of the long-QT syndrome. Circulation 2003; 107: 838-844. (Pubitemid 36241041)
25. Viitasalo M, Oikarinen L, Swan H, Vaananen H, Glatter K, Laitinen PJ, Kontula K, Barron HV, Toivonen L, Scheinman MM,: Ambulatory electrocardiographic evidence of transmural dispersion of repolarization in patients with long-QT syndrome type 1 and 2. Circulation 2002; 106: 2473-2478. (Pubitemid 35278804)
26. Shimizu W, Tanabe Y, Aiba T, Inagaki M, Kurita T, Suyama K, Nagaya N, Taguchi A, Aihara N, Sunagawa K, Nakamura K, Ohe T, Towbin JA, Priori SG, Kamakura S,: Differential effects of beta-blockade on dispersion of repolarization in the absence and presence of sympathetic stimulation between the LQT1 and LQT2 forms of congenital long QT syndrome. J Am Coll Cardiol 2002; 39: 1984-1991. (Pubitemid 34628279)
27. Yamaguchi M, Shimizu M, Ino H, Terai H, Uchiyama K, Oe K, Mabuchi T, Konno T, Kaneda T, Mabuchi H,: T wave peak-to-end interval and QT dispersion in acquired long QT syndrome: A new index for arrhythmogenicity. Clin Sci (Lond) 2003; 105: 671-676. (Pubitemid 38002357)
28. Kannankeril PJ, Harris PA, Norris KJ, Warsy I, Smith PD, Roden DM,: Rate-independent QT shortening during exercise in healthy subjects: Terminal repolarization does not shorten with exercise. J Cardiovasc Electrophysiol 2008; 19: 1284-1288.
29. Gupta P, Patel C, Patel H, Narayanaswamy S, Malhotra B, Green JT, Yan GX,: T(p-e)/QT ratio as an index of arrhythmogenesis. J Electrocardiol 2008; 41: 567-574.
30. Sy RW, Chattha IS, Klein GJ, Gula LJ, Skanes AC, Yee R, Bennett MT, Krahn AD,: Repolarization dynamics during exercise discriminates between LQT1 and LQT2 genotypes. J Cardiovasc Electrophysiol 2010; 21: 1242-1246.
31. Albert CM, Mittleman MA, Chae CU, Lee IM, Hennekens CH, Manson JE,: Triggering of sudden death from cardiac causes by vigorous exertion. N Engl J Med 2000; 343: 1355-1361.
32. Mittleman MA, Siscovick DS,: Physical exertion as a trigger of myocardial infarction and sudden cardiac death. Cardiol Clin 1996; 14: 263-270. (Pubitemid 26153999)
33. Shimizu W, Antzelevitch C,: Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome. J Am Coll Cardiol 2000; 35: 778-786. (Pubitemid 30167037)