Repolarization dynamics during exercise discriminate between LQT1 and LQT2 genotypes

Journal of Cardiovascular Electrophysiology

Volumn 21, Issue 11, 2010, Pages 1242-1246

  Sy, Raymond W ^a   Chattha, Ishvinder S ^a   Klein, George J ^a   Gula, Lorne J ^a   Skanes, Allan C ^a   Yee, Raymond ^a   Bennett, Matthew T ^a   Krahn, Andrew D ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Exercise; Genetic; Long QT syndrome; QT interval; Repolarization

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ADULT; ARTICLE; BICYCLE; CONTROLLED STUDY; EXERCISE TEST; FEMALE; GENE EXPRESSION PROFILING; GENOTYPE; HEART RATE; HEART REPOLARIZATION; HUMAN; LONG QT SYNDROME; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QT PROLONGATION;

ADULT; ELECTROCARDIOGRAPHY; EXERCISE TEST; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEART CONDUCTION SYSTEM; HEART RATE; HUMANS; LONG QT SYNDROME; MALE; PHYSICAL EXERTION; POTASSIUM CHANNELS;

EID: 78249267576     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/j.1540-8167.2010.01788.x     Document Type: Article

References (23)

1. Schwartz PJ, Priori SG, Spazzolini C, Moss AJ, Vincent GM, Napolitano C, Denjoy I, Guicheney P, Breithardt G, Keating MT, Towbin JA, Beggs AH, Brink P, Wilde AA, Toivonen L, Zareba W, Robinson JL, Timothy KW, Corfield V, Wattanasirichaigoon D, Corbett C, Haverkamp W, Schulze-Bahr E, Lehmann MH, Schwartz K, Coumel P, Bloise R,: Genotype-phenotype correlation in the long-QT syndrome: Gene-specific triggers for life-threatening arrhythmias. Circulation 2001; 103: 89 -95.
2. Chauhan VS, Krahn AD, Mitoff P, Klein GJ, Skanes AC, Yee R,: Sudden intense exercise increases QT heart rate slope and T wave complexity in long QT syndrome and normal subjects. Pacing Clin Electrophysiol 2004; 27: 1415 -1423.
3. Takenaka K, Ai T, Shimizu W, Kobori A, Ninomiya T, Otani H, Kubota T, Takaki H, Kamakura S, Horie M,: Exercise stress test amplifies genotype-phenotype correlation in the LQT1 and LQT2 forms of the long-QT syndrome. Circulation 2003; 107: 838 -844.
4. Roden DM,: Clinical practice. Long-QT syndrome. N Engl J Med 2008; 358: 169 -176.
5. Ruan Y, Liu N, Napolitano C, Priori S,: Therapeutic strategies for long-QT Syndrome: Does the molecular substrate matter? Circ Arrhythmia Electrophysiol 2008; 1: 290 -297.
6. Schwartz PJ, Priori SG, Locati EH, Napolitano C, Cantu F, Towbin JA, Keating MT, Hammoude H, Brown AM, Chen LS,: Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy. Circulation 1995; 92: 3381 -3386.
7. Swan H, Viitasalo M, Piippo K, Laitinen P, Kontula K, Toivonen L,: Sinus node function and ventricular repolarization during exercise stress test in long QT syndrome patients with KvLQT1 and HERG potassium channel defects. J Am Coll Cardiol 1999; 34: 823 -829.
8. Chauhan V, Krahn A, Walker BD, Klein G, Skanes A, Yee R,: Sex differences in QTc interval and QT dispersion: Dynamics during exercise and recovery in healthy subjects. Am Heart J 2002; 144: 858 -864.
9. Schwartz PJ,: The congenital long QT syndromes from genotype to phenotype: clinical implications. J Intern Med 2006; 259: 39 -47.
10. Walker BD, Krahn AD, Klein GJ, Skanes AC, Yee R,: Burst bicycle exercise facilitates diagnosis of latent long QT syndrome. Am Heart J 2005; 150: 1059 -1063.
11. Astrand PO, Ryhming I,: A nomogram for calculation of aerobic capacity (physical fitness) from pulse rate during sub-maximal work. J Appl Physiol 1954; 7: 218 -221.
12. Maeder M, Wolber T, Atefy R, Gadza M, Ammann P, Myers J, Rickli H,: Impact of the exercise mode on exercise capacity: Bicycle testing revisited. Chest 2005; 128: 2804 -2811.
13. Anderson ME, Al-Khatib SM, Roden DM, Califf RM,: Cardiac repolarization: Current knowledge, critical gaps, and new approaches to drug development and patient management. Am Heart J 2002; 144: 769 -781.
14. Bazett H,: An analysis of the time relations of electrocardiograms. Heart 1920; 7: 353 -370.
15. Hammond HK, Froelicher VF,: Normal and abnormal heart rate responses to exercise. Prog Cardiovasc Dis 1985; 27: 271 -296.
16. Sanguinetti MC, Jurkiewicz NK,: Two components of cardiac delayed rectifier K +current. Differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol 1990; 96: 195 -215.
17. Kass RS, Wiegers SE,: The ionic basis of concentration-related effects of noradrenaline on the action potential of calf cardiac purkinje fibres. J Physiol 1982; 322: 541 -558.
18. Splawski I, Shen J, Timothy KW, Lehmann MH, Priori S, Robinson JL, Moss AJ, Schwartz PJ, Towbin JA, Vincent GM, Keating MT,: Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation 2000; 102: 1178 -1185.
19. Luo S, Michler K, Johnston P, Macfarlane PW,: A comparison of commonly used QT correction formulae: The effect of heart rate on the QTc of normal ECGs. J Electrocardiol 2004; 37 (Suppl): 81 -90.
20. Hodges M, Salerno D, Erlien D,: Bazett's QT correction reviewed: Evidence that a linear QT correction for heart rate is better. J Am Coll Cardiol 1983; 1: 694.
21. Malik M, Farbom P, Batchvarov V, Hnatkova K, Camm AJ,: Relation between QT and RR intervals is highly individual among healthy subjects: Implications for heart rate correction of the QT interval. Heart 2002; 87: 220 -228.
22. Tester DJ, Will ML, Haglund CM, Ackerman MJ,: Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing. Heart Rhythm 2005; 2: 507 -517.
23. Priori SG, Napolitano C, Schwartz PJ,: Low penetrance in the long-QT syndrome: Clinical impact. Circulation 1999; 99: 529 -533.