TGF-β regulation of focal adhesion proteins and motility of premalignant oral lesions via protein phosphatase 1

Anticancer Research

Volumn 31, Issue 10, 2011, Pages 3159-3164

  Walsh, Jarrett E ^a,b,c   Young, M Rita I ^a,b  

^a RALPH H JOHNSON VA MEDICAL CENTER   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

Cytoskeleton; Paxillin; Phosphatase; PP 1; TGF

Indexed keywords

ACTIN; FOCAL ADHESION KINASE; PAXILLIN; PHOSPHOPROTEIN PHOSPHATASE 1; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER GROWTH; CELL MOTILITY; ENZYME ACTIVITY; LEUKOPLAKIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ACTINS; ANIMALS; CELL MOVEMENT; FOCAL ADHESIONS; HUMANS; MICE; MICE, INBRED C57BL; MOUTH NEOPLASMS; PAXILLIN; PHOSPHORYLATION; PROTEIN PHOSPHATASE 1; PROTEIN TRANSPORT; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 80054729997     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Rees JR, Onwuegbusi BA, Save VE, Alderson D and Fitzgerald RC: In vivo and in vitro evidence for transforming growth factor-β1-mediated epithelial to mesenchymal transition in esophageal adenocarcinoma. Cancer Res 66: 9583-9590, 2006. (Pubitemid 44623657)
2. Ao M, Williams K, Bhowmick NA and Hayward SW: Transforming growth factor-β promotes invasion in tumorigenic but not in nontumorigenic human prostatic epithelial cells. Cancer Res 66: 8007-8016, 2006. (Pubitemid 44299165)
3. Li Y, Yang K, Mao Q, Zheng X, Kong D and Xie L: Inhibition of TGF-β receptor I by siRNA suppresses the motility and invasiveness of T24 bladder cancer cells via modulation of integrins and matrix metalloproteinase. Int Urol Nephrol 42: 315-323, 2010.
4. Chow JYC, Dong H, Quach KT, Van Nguyen PN, Chen K and Carethers JM: TGF-β mediates PTEN suppression and cell motility through calcium-dependent PKC-α activation in pancreatic cancer cells. Am J Physiol Gastrointest Liver Physiol 294: G899-G905, 2008. (Pubitemid 351520064)
5. Kim ES, Kim JS, Kim SG, Hwang S, Lee CH and Moon A: Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-Gαq coupling. J Cell Sci 124: 2220-2230, 2011.
6. Young MRI, Liu SW and Meisinger J: Differences in association of the serine/threonine protein phosphatase PP-2A with microtubules of metastatic and nonmetastatic tumor cells. Clin Exp Metastasis 18: 407-413, 2001. (Pubitemid 32588621)
7. Schonrath K, Pan W, Klein-Szanto AJ and Braunewell KH: Involvement of VILIP-1 (visinin-like protein) and opposite roles of cyclic AMP and GMP signaling in in vitro cell migration of murine skin squamous cell carcinoma. Mol Carcinog 50: 319-333, 2011.
8. Crosswell HE, Dasgupta A, Alvarado CS, Watt T, Christensen JG, De P, Durden DL and Findley HW: PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells. BMC Cancer 9: 411, 2009.
9. Laukaitis CM, Webb DJ, Donais K and Horwitz AF: Differential dynamics of α5 integrin, paxillin, and α-actinin during formation and disassembly of adhesions in migrating cells. J Cell Biol 153: 1427-1440, 2001. (Pubitemid 34286127)
10. Jamieson JS, Tumbarello DA, Halle M, Brown MC, Tremblay ML and Turner CE: Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker. J Cell Sci 118: 5835-5847, 2005. (Pubitemid 43079276)
11. Zhu H, Zhao J, Zhu B, Collazo J, Gal J, Shi P, Liu L, Strom AL, Lu X, McCann RO, Toborek M and Kyprianou N: EMMPRIN regulates cytoskeleton reorganization and cell adhesion in prostate cancer. Prostate, in press, 2011. (published online May 11, 2011)
12. Abiatari I, Esposito I, Oliveira TD, Felix K, Xin H, Penzel R, Giese T, Friess H and Kleeff J: Moesin-dependent cytoskeleton remodelling is associated with an anaplastic phenotype of pancreatic cancer. J Cell Mol Med 14: 1166-1179, 2010.
13. Jackson JL and Young MR: Protein phosphatase-2A modulates the serine and tyrosine phosphorylation of paxillin in Lewis lung carcinoma tumor variants. Clin Exp Metastasis 19: 409-415, 2002. (Pubitemid 34876208)
14. Leve F, de Souza W and Morgado-Diaz JA: A cross-link between protein kinase A and rho-family GTPases signaling mediates cell-cell adhesion and actin cytoskeleton organization in epithelial cancer cells. J Pharmacol Exp Ther 327: 777-788, 2008.
15. Franzen CA, Amargo E, Todorovic V, Desai BV, Huda S, Mirzoeva S, Chiu K, Grzybowski BA, Chew TL, Green KJ and Pelling JC: The chemopreventive bioflavonoid apigenin inhibits prostate cancer cell motility through the focal adhesion kinase/Src signaling mechanism. Cancer Prev Res 2: 830-841, 2009.
16. Young MRI, Kolesiak K and Meisinger J: Protein phosphatase-2A regulates endothelial cell motility and both the phosphorylation as well as stability of focal adhesion complexes. Int J Cancer 100: 276-282, 2002. (Pubitemid 34728984)
17. Walsh JE and Young MR: Interrelationship between protein phosphatase 1 and TGF-β in regulating motility and cytoskeletal architecture of endothelial cells. Anticancer Res 30: 4861-4866, 2010.
18. Romashko AA and Young MRI: Protein phosphatase-2A maintains focal adhesion complexes in keratinocytes and the loss of this regulation in squamous cell carcinomas. Clin Exp Metastasis 21: 371-379, 2004.
19. Young MR, Liu SW and Meisinger J: Protein phosphatase-2A restricts migration of Lewis lung carcinoma cells by modulating the phosphorylation of focal adhesion proteins. Int J Cancer 103: 38-44, 2003. (Pubitemid 35424203)
20. Sontag JM and Sontag E: Regulation of cell adhesion by PP2A and SV40 small tumor antigen: an important link to cell transformation. Cell Mol Life Sci 63: 2979-2991, 2006.
21. Xu L and Deng X: Suppression of cancer cell migration and invasion by protein phosphatase 2A through dephosphorylation of μ- and m-calpains. J Biol Chem 281: 35567-35575, 2006. (Pubitemid 46036590)
22. 2 and transforming growth factor-β stimulate endothelial cell motility through inhibition of protein phosphatase-2A and involvement of PTEN and phosphatidylinositide 3-kinase. Angiogenesis 7: 123-131, 2004.